A5028813107- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Dental Implant Techniques and Outcomes
- Adipose Tissue and Metabolism
- Orthodontics and Dentofacial Orthopedics
- Epilepsy research and treatment
- Cancer, Lipids, and Metabolism
- Pharmacological Effects and Toxicity Studies
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Lung Cancer Research Studies
- Drug Transport and Resistance Mechanisms
- COVID-19 Clinical Research Studies
- Dental materials and restorations
- interferon and immune responses
- Gastrointestinal motility and disorders
- Tryptophan and brain disorders
- Temporomandibular Joint Disorders
Shanghai Stomatological Hospital
2023-2025
Fudan University
2023-2025
Tsinghua University
2025
Xi'an Jiaotong University
2024
Central South University
2015-2024
First Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Nanjing University of Posts and Telecommunications
2024
Xiangya Hospital Central South University
2014-2023
China University of Petroleum, East China
2022-2023
Ferroptosis is an iron-dependent cell death process that plays important regulatory roles in the occurrence and development of cancers, including hepatocellular carcinoma (HCC). Moreover, molecular events surrounding aberrantly expressed long non-coding RNAs (lncRNAs) drive HCC initiation progression have attracted increasing attention. However, research on ferroptosis-related lncRNA prognostic signature patients with still lacking. In this study, association between differentially lncRNAs...
The poly ADP ribose polymerase (PARP) inhibitor olaparib has been approved for treating prostate cancer (PCa) with BRCA mutations, and veliparib, another PARP inhibitor, is being tested in clinical trials. However, veliparib only showed a moderate anticancer effect, combination therapy required PCa patients. Histone deacetylase (HDAC) inhibitors have to improve the efficacy of cells, but exact mechanisms are still elusive.Several types cells epithelial cell line RWPE-1 were treated or SAHA...
The gasdermin (GSDM) superfamily has been demonstrated to consist of several important molecules that modulate multifunctional signal processes, such as cell pyroptosis. In this research, the roles GSDM on occurrence and prognosis lung adenocarcinoma (LUAD) were evaluated using integrative bioinformatic analyses in vitro methods. Here, data from platforms revealed GSDMC is significantly upregulated LUAD tissues lines. Real‑time fluorescence quantitative PCR (qPCR) was obviously...
Background: LncRNAs have been shown to play essential roles in cancer therapeutic response. However, the detailed mechanism of lncRNAs temozolomide (TMZ) resistance glioblastoma (GBM) remain be elucidated. Methods: To elucidate maintaining TMZ resistance, we constructed two TMZ-resistant GBM cell lines (T98G-R/U118-R). from four public datasets were reanalyzed, and candidate lncRNA ADAMTS9-AS2 was evaluated TMZ-treated patients vitro lines. Results: Reanalysis expression profiles identified...
Objectives: Emerging evidence suggests that gut microbiota dysbiosis plays a critical role in chronic kidney disease (CKD). However, the relationship between altered microbiome profiles and severity remains unclear. In this study, we sought to characterize CKD patients compared healthy controls, explore potential relationships composition severity. Methods: Fecal samples were collected from 95 at different stages of (non-dialysis stage 1 5) 20 controls. Bacterial DNA was extracted for 16S...
Overall, 12% of the global population (800 million) suffers from liver disease, which causes 2 million deaths every year. Liver injury involving characteristic reactive oxygen/nitrogen species (RONS) and inflammation plays a key role in progression disease. As metabolic organ human body, is susceptible to various sources, including COVID-19 infection. Owing unique structural features functions liver, most current antioxidants anti-inflammatory drugs are limited against injury. However,...
Resistance to temozolomide (TMZ), the standard chemotherapy agent for glioblastoma (GBM), poses a major clinical challenge GBM prognosis. Understanding mechanisms of TMZ resistance can help identify novel drug targets and more effective therapies. Recent studies suggest that bioenergetic alterations cancer cells play important roles in resistance. In our study, altered metabolism was observed using metabolic PCR array. We found stearoyl-coenzyme A desaturase 1 (SCD1), key rate-limiting...
Background . Fluoxetine (FLU) is the first-line and widely used medication for depression; however, FLU treatment almost ineffective in 30%-40% of patients with depression. In addition, there are some problems treatment, such as delayed efficacy, large side effects, poor tolerance. Chaihu Shugan San (CSS) a classic effective antidepressant Chinese herbal medicine that has been China thousands years. CSS or coadministration become one most recommended methods depression China. However,...
Growing evidence has shown that the gut-renal connection and gut microbiota dysbiosis play a critical role in immunoglobulin A nephropathy (IgAN). However, fecal microbiome profile Chinese patients with IgAN remains unknown. cross-sectional study was designed for first time to investigate compositions primary China evaluate relationship between clinical presentation.Fecal samples were collected from 17 18 age-, sex-, body mass index-matched healthy controls, bacterial DNA extracted 16S...
There is increasing evidence for the contribution of synuclein alpha (SNCA) to etiology neurological disorders, such as Parkinson’s disease (PD). However, little known about detailed role SNCA in human cancers, especially lung cancers. Here, we evaluated effects on occurrence and prognosis adenocarcinoma (ADC). Comprehensive bioinformatics analyses data obtained from Oncomine platform, protein atlas (HPA) project cancer cell line encyclopedia (CCLE) demonstrated that expression was...
Ionizing radiation (IR) is a conventional cancer therapeutic, to which cells develop radioresistance with exposure. The residual after treatment also have increased metastatic potential. mechanisms by and gain potential are still unknown. In this study acute IR exposure induced cell senescence apoptosis, but long-term exposure, exhibited radioresistance. proliferation of radioresistant was retarded, most were arrested in G0/G1 phase. simultaneously showed resistance further IR-induced...
Lung adenocarcinoma (LUAD) is the most common histological form of lung cancer that clinically diagnosed. The aim this study to explore novel genes associated with LUAD tumorigenesis. Comprehensive bioinformatics analyses data were obtained from several publicly available databases, such as Gene Expression Omnibus, Human Protein Atlas project, and Cancer Cell Line Encyclopedia. clinical relevance these in was further examined by immunohistochemistry. We identified overlapping differentially...