A5101687064- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Ion channel regulation and function
- Trace Elements in Health
- HIV/AIDS drug development and treatment
- Ion Transport and Channel Regulation
- Antibiotics Pharmacokinetics and Efficacy
- Peroxisome Proliferator-Activated Receptors
- Metabolism and Genetic Disorders
- Advanced biosensing and bioanalysis techniques
- Vitamin D Research Studies
- Ferroptosis and cancer prognosis
- Neuroscience and Neuropharmacology Research
- Vitamin C and Antioxidants Research
- Burkholderia infections and melioidosis
- Medicinal Plant Pharmacodynamics Research
- Brucella: diagnosis, epidemiology, treatment
- Genomics and Rare Diseases
- Phytochemicals and Antioxidant Activities
- Fungal Plant Pathogen Control
- Macrophage Migration Inhibitory Factor
- Cardiac Valve Diseases and Treatments
- Sex and Gender in Healthcare
- Traditional Chinese Medicine Analysis
Xiangya Hospital Central South University
2014-2024
Central South University
2014-2024
E Ink (South Korea)
2023
Creative Commons
2023
Hunan Academy of Traditional Chinese Medicine
2021
Creighton University
2017
SUMMARY Aims: Some study found that ATP‐binding cassette (ABC) efflux transporters play an important role in antiepileptic drug resistance, especially ABCB1 and ABCC2 . The aims of this were to evaluate the relationship between genetic polymorphisms therapeutic efficacy drugs (AEDs) Chinese epileptic patients. Methods: rs1045642 (3435C>T) rs717620 (−24C>T), rs3740066 (3972C>T), rs2273697 (1249G>A) loci 537 epilepsy patients (217 resistant 320 responders) genotyped by polymerase...
1. Chemotherapeutic resistance to platinum-based anticancer drugs is a major obstacle in the successful treatment of lung cancer. Cellular uptake and platinum accumulation are considered most important factors contributing resistance. The copper transporter family plasma membrane for uptake. Copper protein 1 (CTR1) plays an essential role cisplatin influx closely related by influencing accumulation. aim present study was determine whether CTR1 polymorphisms associated with non-small cell...
SUMMARY Aims: To investigate the tolerability and efficacy of carbamazepine treatment in patients with partial‐onset seizures association polymorphisms sodium channel α‐subunit type 1 ( SCN1A ), gamma ‐aminobutyric acid (GABA) receptor genes among Chinese Han population. Methods: 448 were genotyped for single nucleotide selected GABA‐receptor genes. Monotherapy (CBZ) was administered to patients. The effectiveness CBZ evaluated regard by decrease retention rates. Results: rs3812718 A/G P =...
Abstract The level of serum 25-Hydroxyvitamin D [25(OH)D] has high heritability, suggesting that genes may contribute to variations in 25(OH)D and vitamin dose-response. As deficiency been linked numerous diseases, understanding how genetic variation contributes dose-response is important for personalized treatment cost-effective disease prevention. To identify variants responsible status dose-response, we performed two D3 calcium clinical supplementation trials 2,207 postmenopausal...
Aim Platinum‐induced toxicity severely impedes successful chemotherapy in lung cancer patients. The nucleotide excision repair ( NER ) pathway is considered as one of the major factors contributing to platinum effects. Furthermore, genetic variances influence toxicity. eIF3α , over expressed many malignancies, an up‐stream gene and could regulate its activity. purpose this study was investigate whether polymorphism associated with severe patients non‐small cell NSCLC ). Methods Two hundred...
Oxaliplatin is a chemotherapeutic agent used in the treatment of colorectal cancers. However, mechanism controlling cellular uptake and efflux oxaliplatin not completely understood. Organic cation/carnitine transporter 2 (OCTN2) member solute carrier superfamily determinant uptake. OCTN2 regulated by peroxisome proliferator-activated receptor γ (PPARγ) binding to PPAR-response element within first intron. Luteolin naturally occurring flavonoid an agonist PPARγ. Thus, we hypothesize that...
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Repaglinide is an insulin secretagogue agent widely used in the treatment of type 2 diabetes mellitus (T2DM). Obvious interindividual differences therapeutic efficacy and adverse reactions to repaglinide were observed Chinese T2DM patients. There are no reports showing influence genetic variations NeuroD1/BETA2 A45T PAX4 R121W on response STUDY ADDS This study aimed investigate association polymorphisms with susceptibility The correlated AIMS We...
The aim of the present study was to investigate whether single nucleotide polymorphisms (SNPs) in sodium channel a subunit type 1 (SCN1A) gene affect retention rate carbamazepine (CBZ) used treat seizures Chinese Han patients with epilepsy. In total, 448 were genotyped for SNPs selected SCN1A gene. tag using Haploview version 4.2 software (http://www.broad.mit.edu/haploview/haploview, accessed 18 Sept 2009). Monotherapy CBZ administered new-onset focal seizures. study, defined as percentage...
A series of studies have indicated that valproic acid (VPA) plasma concentration decreased rapidly when used concomitantly with carbapenem antibiotics, including meropenem (MEPM), imipenem and panipenem, which may increase the risk seizure breakthrough. However, cause for change in VPA pharmacokinetics is unclear. retrospective analysis therapeutic drug monitoring (TDM) records was performed to investigate this drug-drug interaction.Three hundred eighty one TDM from Department Neurosurgery...
Summary Aims The causes of genetic generalized epilepsies ( GGE s) are still uncertain now. Some studies found that the human potassium channel, subfamily T, member 1 KCNT ) is candidate gene causing malignant migrating partial seizures infancy and autosomal dominant nocturnal frontal lobe epilepsy which all rare epilepsies. aims this study were going to evaluate association between common variations susceptibility drug resistance in Chinese population. Methods allele‐specific MALDI – TOF...
Previous studies reported that the proline-rich transmembrane protein 2 (PRRT2) gene was identified to be related paroxysmal kinesigenic dyskinesia (PKD), infantile convulsions with PKD, PKD migraine and benign familial epilepsy (BFIE). The present study explores whether PRRT2 mutation is a potential cause of febrile seizures, including seizures plus (FS+), generalized (GEFS+) Dravet syndrome (DS); thus, it may provide new drug target for personalized medicine seizure patients. We screened...
This study aims to investigate the influence of ATP7B genetic polymorphism platinum-based chemotherapy in Chinese Han lung cancer patients. A total 338 patients were enrolled this study. All underwent at least two cycles chemotherapy. Four tag SNPs (rs1061472, rs9535826, rs7999812, and rs9535828) selected evaluate their impacts these rs9535828 rs9535826 found be associated with platinum resistance Patients allele presented an increased susceptibility drugs (OR 1.96, 95 % CI 1.17-3.30, p <...
To investigate whether single nucleotide polymorphisms (SNPs) of rs2298771 and rs3812718 the sodium channel α-subunit type 1 (SCN1A) gene affect efficacy carbamazepine (CBZ) treatment for seizures in Chinese Han epileptic patients.SNP SCN1A from 628 patients were genotyped. CBZ monotherapy was administered to subjects with new-onset partial seizures. The defined as decrease number Four semi-quantitative levels used assess efficacy: seizure-free (SF), >75% seizure (SD), 50%-75% SD, <50% SD...
Many phytochemicals exert activities as agonists of peroxisome proliferator-activated receptor gamma (PPARγ). This study aims to investigate whether are the PPARγ/RXRα pathway and modulate target gene OCTN2. In this study, a luciferase reporter system was used screen novel OCTN2 activators from 39 phytochemicals. Kaempferol, curcumin puerarin were found show significant PPRE-mediated (>150%) at 20 μM showed dose-dependent manner. Phytochemicals also elevated mRNA protein expression in...