A5102856360- Gut microbiota and health
- Pharmacogenetics and Drug Metabolism
- Cancer Immunotherapy and Biomarkers
- Diet and metabolism studies
- Respiratory and Cough-Related Research
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Asthma and respiratory diseases
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Genetic Associations and Epidemiology
- Pancreatic and Hepatic Oncology Research
- Pharmacological Effects and Toxicity Studies
- Potassium and Related Disorders
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- Cardiovascular Function and Risk Factors
- Computational Drug Discovery Methods
- Problem and Project Based Learning
- Lung Cancer Research Studies
- Innovative Teaching Methods
- Lipoproteins and Cardiovascular Health
Central South University
2015-2025
Second Xiangya Hospital of Central South University
2017-2025
Xiangya Hospital Central South University
2014-2023
PharmacoGenetics (China)
2013-2023
National Clinical Research Center for Digestive Diseases
2023
Oita University
2016
Aim Immune checkpoint inhibitors (ICIs) have updated the treatment landscape for patients with advanced malignancies, while their clinical prospect was hindered by severe immune-related adverse events (irAEs). The aim of this study to research association between gut microbiome diversity and occurrence ICI-induced irAEs. Patients Method We prospectively obtained baseline fecal samples data from treated anti-PD-1 as monotherapy or in combination chemotherapy antiangiogenesis regardless lines....
Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for patients with advanced non-small-cell lung cancer (aNSCLC), but immune-related adverse events (irAEs) been evidenced curtailed clinical use of them.The aim this study was to research influences inflammation-related peripheral blood markers, including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) levels, on anti-PD-1 inhibitor-induced irAEs.A retrospective analysis conducted treated PD-1...
Background: Given the limitations of traditional pharmacology pedagogical method, diverse novel teaching methods have been widely explored. In this study, we performed a network meta-analysis (NMA) to evaluate effects different strategies in education. Methods: Literature databases were searched from their inception November 2022, and studies screened according predefined inclusion exclusion criteria extract important information. Outcomes, including theoretical test scores, experimental...
Objective: The optimal probiotic supplementation in pregnant women has not been thoroughly evaluated. By employing a network meta-analysis (NMA) approach, we compared the effectiveness of different strategies for women. Methods: A comprehensive search across multiple databases was performed to identify studies comparing efficacy supplements with each other or control (placebo) among Results: This NMA, including 32 studies, systematically evaluated 6 supplement strategies: Lactobacillus,...
Objective ABO genetic polymorphisms have recently been associated with angiotensin-converting enzyme (ACE) activity and inflammation, which play a critical role in the pathogenic mechanism of ACE inhibitor-induced cough. Therefore, current study determined association enalapril-induced cough Chinese patients essential hypertension. Methods A total 450 hypertensive treated 10 mg enalapril maleate were genotyped for using PCR-direct sequencing method. Cough was recorded when bothered by...
Abstract Clinical observations suggest that incidence of cough in Chinese taking angiotensin converting enzyme inhibitors is much higher than other racial groups. Cough the most common adverse reaction enalapril. We investigate whether SLCO1B1 genetic polymorphisms, previously reported to be important determinants inter-individual variability enalapril pharmacokinetics, are associated with enalapril-induced cough. A cohort 450 patients essential hypertension 10 mg maleate were genotyped for...
Background and Objective: Apolipoprotein E (APOE) plays important roles in lipoprotein metabolism cardiovascular disease. Evidence suggests the APOE gene epsilon2/epsilon3/epsilon4 (ε2/ε3/ε4) polymorphisms might be associated with susceptibility of coronary artery disease (CAD) patients type 2 diabetes mellitus (T2DM). However, no clear consensus has yet been established. Therefore, aim this meta-analysis is to provide a precise conclusion on potential association between ε2/ε3/ε4 risk CAD...
Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite. The effects of CES1 S75N (rs2307240,C>T) on response among 851 acute coronary syndrome patients who came from north, central and south China were studied. occurrence ratios each endpoint in CC group significantly higher than CT + TT for cerebrovascular events (14% vs 4.8%, p < 0.001, OR = 0.31), myocardial infarction (15.1% 6.1%, 0.37) unstable angina (62.8% 37.7%, 0.36). results showed...
The role of anti-diabetic medications in pancreatic cancer remains conflicting. We carried out a systematic search Pubmed and Embase databases for studies published before August 2016, which assessed the associations between (metformin, sulfonylureas, thiazolidinediones insulin) intake prognosis. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using random-effects model. primary outcomes interest overall survival (OS) progression-free (PFS). Fourteen enrolling 94778...
Liver injury caused by first-line anti-tuberculosis (anti-TB) drugs accounts for a high proportion of drug-induced liver (DILI), and gut microbiota intestinal barrier integrity have been shown to be involved in the development DILI. Magnesium isoglycyrrhizinate (MgIG) is fourth-generation glycyrrhizic acid preparation, which well documented effective against anti-TB DILI, but underlying mechanism largely unclear. In present study, we established BALB/c mice animal model HRZE regimen (39...
Aim: The mineralocorticoid receptor (MR; also known as NR3C2) plays important roles in the modulation of blood pressure. effect NR3C2 polymorphisms on antihypertensive response to enalapril was investigated. Patients & methods: Two hundred and seventy nine essential hypertension patients treated with were genotyped for two tagSNPs, rs5522 rs2070950, by Sequenom MassArray™ technology. Results: reductions diastolic pressure (DBP) significantly greater AA homozygotes compared AG+GG genotype...
Background KCNH2 (hERG) potassium channels have an integral role in regulating the excitability of smooth muscle cells. Some pathways driven by angiotensin II, nitric oxide and adrenergic receptors blocker are involved modulating properties channels. And these closely related to blood pressure regulation. Therefore, we hypothesized that genetic polymorphisms may affect response antihypertensive drug therapies. Materials Methods To evaluate interactions between individual drugs, 370 subjects...