A5101831808- Cancer-related molecular mechanisms research
- Pharmacogenetics and Drug Metabolism
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Inflammatory mediators and NSAID effects
- RNA Research and Splicing
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Effects of Natural Compounds
- Cancer, Lipids, and Metabolism
- Hormonal Regulation and Hypertension
- Ginseng Biological Effects and Applications
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Estrogen and related hormone effects
- Lung Cancer Treatments and Mutations
- Histone Deacetylase Inhibitors Research
- Antibiotics Pharmacokinetics and Efficacy
- Statistical Methods in Clinical Trials
- PI3K/AKT/mTOR signaling in cancer
Xiangya Hospital Central South University
2015-2025
Central South University
2015-2025
Huazhong University of Science and Technology
2025
Tongji Hospital
2025
Beijing University of Technology
2024
PharmacoGenetics (China)
2013-2023
Weatherford College
2021
National Clinical Research Center for Digestive Diseases
2019-2021
Chongqing Medical University
2017-2020
Long non-coding RNAs (lncRNAs) play important roles in carcinogenesis and drug efficacy. Platinum-based chemotherapy is first-line treatment for lung cancer chemotherapy. In this study, we aimed to investigate the association of well-characterized lncRNA genetic polymorphisms with susceptibility platinum-based response. A total 498 patients 213 healthy controls were recruited study. Among them, 467 received at least two cycles Thirteen HOXA distal transcript antisense RNA (HOTTIP), HOX...
Abstract Background MYB-related protein B (B-MYB/MYBL2), a member of the myeloblastosis family transcription factors, has been reported for its role in genesis and progression tumors. Forkhead box M1 (FoxM1), another transcriptional factor, is considered to be an independent predictor poor survival many solid cancers. The aim present study was investigate clinical significance correlation between MYBL2 FoxM1 glioma possible mechanism FoxM1and expression. Methods FoxM1expression cancerous...
Emerging studies show that long noncoding RNAs (lncRNAs) have important roles in carcinogenesis. lncRNA ZEB1 antisense 1 (ZEB1-AS1) is a novel lncRNA, whose clinical significance, biological function, and underlying mechanism remains unclear glioma. Here, we found ZEB1-AS1 was highly expressed glioma tissues, being closely related to stage of Moreover, patients with high levels had poor prognoses, the evidence provided by multivariate Cox regression analysis indicating expression could serve...
Background: Despite great advances in the diagnosis and treatment of non-small cell lung cancer (NSCLC), early remains a challenge because patients usually have advanced at time they are diagnosed. The limited efficacy conventional chemotherapy is another major problem NSCLC. Based on published set sequencing data, we find that hsa_circ_0001946 circRNA molecule with significantly different expression level three lines (human normal fibroblasts line MRC-5, human NSCLC A549,...
Dysregulated long noncoding RNAs (lncRNAs) are potential markers of several tumor prognoses. This study aimed to develop a lncRNA expression signature that can predict chemotherapeutic sensitivity for patients with advanced stage and high-grade serous ovarian cancer (HGS-OvCa) treated platinum-based chemotherapy. The profiles 258 HGS-OvCa from Cancer Genome Atlas were analyzed. Results revealed an eight-lncRNA was significantly associated chemosensitivity in the multivariate logistic...
Abstract Our previous studied indicated that eukaryotic translation initiation factor 3a (eIF3a) increases the sensitive of platinum-based chemotherapy in lung cancer. MiRNAs play an important role carcinogenesis and drug response. In this study, we aimed to identify potential endogenous miRNAs inhibit eIF3a expression determine their influence inhibition on cisplatin resistance. Using bioinformatics analysis prediction confirmation with dual-luciferase reporter assays, found miRNA-488...
Epigenetic alterations are strongly associated with the development of cancer. The aim this study was to identify epigenetic pattern in squamous cell lung cancer (LUSC) on a genome-wide scale. Here we performed DNA methylation profiling 24 LUSC and paired non-tumor (NTL) tissues by Illumina Human Methylation 450 K BeadArrays, identified 5214 differentially methylated probes. By integrating mRNA expression data, 449 aberrantly genes accompanied altered were identified. Ingenuity Pathway...
This study aims to identify effective gene networks and prognostic biomarkers associated with estrogen receptor positive (ER+) breast cancer using human mRNA studies. Weighted coexpression network analysis was performed a complex ER+ transcriptome investigate the function of key genes in prognosis cancer. We found significant correlation an expression module distant metastasis-free survival (HR = 2.25; 95% CI .21.03–4.88 discovery set; HR 1.78; 1.07–2.93 validation set). contained enriched...
SUMMARY Quercetin, one of the most abundant natural flavonoids, has been reported to modulate activity several drug‐metabolising enzymes. The aim present study was investigate effects quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N ‐acetyltransferase (NAT2) and xanthine oxidase (XO) in healthy volunteers using caffeine as a probe drug. Twelve unrelated, were recruited study. There two phases study; first phase, each subject given single oral dose (one 100 mg capsule) with 150 mL water;...
Diffuse gliomas are well known malignant brain tumors. Long non-coding RNAs (lncRNAs), a type of RNA transcript with more than 200 nucleotides, involve in tumorigenesis and development various cancers. This study focused on identifying differentially expressed lncRNAs based gene expression profiling, chose certain PVT1, CYTOR, HAR1A MIAT, which changed significant differences. Further analysis TCGA GEO data revealed that the expressions PVT1 CYTOR were up-regulated, while MIAT down-regulated...
Whether long non-coding RNA (lncRNA) single-nucleotide polymorphisms (SNPs) affect prognosis of acute myeloid leukemia (AML) remains unknown. To search the association between lncRNA SNPs and AML outcomes, thirty tagSNPs in five lncRNAs were genotyped 313 patients. Survival analysis indicated that GAS5 rs55829688 (T > C) was significantly associated with (p = 0.018). Patients CC genotype showed higher expression peripheral blood mononuclear cells (PBMCs) 0.025) harbored a longer platelets...
ABSTRACT Ginsenoside compound K (GCK) has been proved to have great hypoglycemic effect pertinent gut microbiota. However, the improvement of high‐fat‐diet (HFD)‐induced type 2 diabetes (T2D) as well mechanism GCK mediated by microbiota is not well‐known. This study aimed investigate effects and on a HFD‐induced diabetic mouse model. pseudo‐germ free (GF) T2D mice model fecal transplantation (FMT) experiments were performed clarify role in GCK. Differential metabolites screened untargeted...
For advanced hepatocellular carcinoma (HCC), effective treatment options remain scarce. The risks of surgery and the likelihood tumor residue restrict use liver resection. However, combination systemic therapy with locoregional treatments has recently demonstrated promising anti-tumor efficacy, offering new avenues for HCC. We detail case a 61-year-old male who is free viral hepatitis alcohol consumption, but overweight body mass index (BMI) 25.2 kg/m2. A magnetic resonance imaging (MRI),...
Objective: Breast cancer seriously endangers women's health. It is very important to analyze the lifestyle and genetic risk factors for people with malignant or suspected nodules in breast screening prevention of cancer. Methods: A total 3142 urban female residents southern China completed a clinical The participants questionnaires on living environmental underwent imaging examinations testing 73 SNP loci. According BI-RADS classification results, population was divided into positive...
To evaluate the effect of CYP1A2*1C and CYP1A2*1F polymorphisms on inducibility CYP1A2 by omeprazole in healthy subjects.Mutations CYP2C19 were identified PCR-RFLP. Omeprazole, 120 mg day-1, was given to 12 extensive metabolizers (EM) with respect (six CYP1A2*1F/CYP1A2*1F six CYP1A2*1C/CYP1A2*1F CYP1A2) for 7 days. activity determined three occasions, namely day 1, 9 16 using caffeine plasma index (the ratio concentrations paraxanthine caffeine), 6 h after oral administration 200...