A5069521470- Sulfur Compounds in Biology
- Cancer, Stress, Anesthesia, and Immune Response
- Melanoma and MAPK Pathways
- Cancer-related molecular mechanisms research
- Neuroscience of respiration and sleep
- Epigenetics and DNA Methylation
- Alcohol Consumption and Health Effects
- RNA Research and Splicing
- FOXO transcription factor regulation
- Acute Myeloid Leukemia Research
- Genomics, phytochemicals, and oxidative stress
- Air Quality and Health Impacts
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- Hematopoietic Stem Cell Transplantation
- Microtubule and mitosis dynamics
- Circular RNAs in diseases
- Viral-associated cancers and disorders
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Synthesis and biological activity
- Molecular Sensors and Ion Detection
- Chemokine receptors and signaling
- Ubiquitin and proteasome pathways
- Neurological Disorders and Treatments
Chongqing Medical University
2023-2024
Army Medical University
2020-2023
Southwest Hospital
2020-2023
Xiangya Hospital Central South University
2017-2022
Central South University
2016-2022
University of South China
2011-2020
Xiamen University
2020
National Clinical Research Center for Digestive Diseases
2019
PharmacoGenetics (China)
2016-2019
Changsha University
2016
Mitochondria are key regulators of hematopoietic stem cell (HSC) homeostasis. Our research identifies the transcription factor Nynrin as a crucial regulator HSC maintenance by modulating mitochondrial function. is highly expressed in HSCs under both steady-state and stress conditions. The knockout diminishes frequency, dormancy, self-renewal, with increased dysfunction indicated abnormal mPTP opening, swelling, elevated ROS levels. These changes reduce radiation tolerance promote...
Dysregulated long noncoding RNAs (lncRNAs) are potential markers of several tumor prognoses. This study aimed to develop a lncRNA expression signature that can predict chemotherapeutic sensitivity for patients with advanced stage and high-grade serous ovarian cancer (HGS-OvCa) treated platinum-based chemotherapy. The profiles 258 HGS-OvCa from Cancer Genome Atlas were analyzed. Results revealed an eight-lncRNA was significantly associated chemosensitivity in the multivariate logistic...
Both preclinical and epidemiology studies associate β-adrenoceptors-blockers (β-blockers) with activity against melanoma. However, the underlying mechanism is still unclear, especially in acral In this study, we explored effect of propranolol, a non-selective β-blocker, on A375 melanoma cell line, two primary lines (P-3, P-6) mice xenografts. Cell viability assay demonstrated that 50μM-400μM propranolol inhibited concentration time dependent manner an IC50 ranging from 65.33μM to 148.60μM...
The oncogene DEK is found fused with the NUP214 gene creating oncoprotein DEK-NUP214 that induces acute myeloid leukemia (AML) in patients, and secreted protein functions as a hematopoietic cytokine to regulate hematopoiesis; however, intrinsic role of nuclear stem cells (HSCs) remains largely unknown. Here, we show HSCs lacking display defects long-term self-renew capacity, eventually resulting impaired hematopoiesis. deficiency reduces quiescence accelerates mitochondrial metabolism HSCs,...
Formaldehyde (FA) is a common environmental contaminant that has toxic effects on the central nervous system (CNS). Our previous data demonstrated hydrogen sulfide (H2S), third endogenous gaseous mediator, protective against FA-induced neurotoxicity. As known to all, Brain-derived neurotropic factor (BDNF), member of neurotrophin gene family, mediates its neuroprotective properties via various intracellular signaling pathways triggered by activating tyrosine kinase receptor B (TrkB)....
Background Formaldehyde (FA) induces neurotoxicity by overproduction of intracellular reactive oxygen species (ROS). Increasing studies have shown that hydrogen sulfide (H2S), an endogenous gastransmitter, protects nerve cells against oxidative stress its antioxidant effect. It has been nitric oxide (NO) inhibits the activity cystathionine-beta-synthase (CBS), predominant H2S-generating enzyme in central nervous system. Objective We hypothesize FA-caused involves deficiency this protective...
Abstract Forkhead box M1 (FoxM1) transcriptional factor has a principal role in regulating cell proliferation, self-renewal, and tumorigenesis. However, whether FoxM1 regulates endogenous muscle development regeneration remains unclear. Here we found that loss of satellite cells (SCs) resulted atrophy defective regeneration. functioned as direct transcription activator adenomatous polyposis coli (Apc), preventing hyperactivation wnt/β-catenin signaling during overexpression SCs promoted...
The purpose of this study is to develop an effective but concise long non-coding RNA (lncRNA) expression signature that can predict response neoadjuvant chemotherapy for breast cancer (BC) patients.lncRNA profiling in 1102 BC patients from Gene Expression Omnibus datasets was analyzed using lncRNA-mining approach. association between lncRNA and pathological complete (pCR) logistic regression model the training set (GSE25066, n = 488). Validation performed independent testing datasets,...
Both sunitinib, a multi-target tyrosine kinase inhibitor (TKI) and propranolol, non-selective β-blocker, have proven therapeutic effects on malignant melanoma (MM). This study reports synergistic effect of propranolol sunitinib upon A375, P8 MM cell lines mice xenografts. Cell viability assays detected significant decrease IC50 in combination with which was confirmed by colony formation assay. Western blot showed that significantly down-regulated phospho-Rb, phospho-ERK, Cyclin D1, E, but...
Ischemic stroke is a leading cause of morbidity and mortality. Thrombolytic therapy improves disability survival rates; however, to be effective, it must given within 4.5 h onset. Moreover, thrombolytic frequently contraindicated. Therefore, alternative therapeutic options are required. In China, cinepazide maleate injection has been shown improve the cerebral collateral circulation further reduce in patients; very few studies investigating this have conducted date. study aimed confirm...
Calcium overload plays an important role in ischemia/reperfusion injury during ischemic brain damage and is mediated by calmodulin (CaM). However, the understanding of regulatory mechanisms CaM expression at gene level limited. The levels miR-26b change significantly ACI, bioinformatic analyses predict that would be a potential regulator (CALM1) mRNA. This study aimed to determine plasma patients with ACI investigate impact on CALM1 expression.CaM from normal controls were performed using...
Wound healing is the treatment problem after deep second degree (II°) burns. The p38 mitogen-activated protein kinase (p38 MAPK) and nuclear factor-κB/inhibitory factor-κB (NF-κB/IκB) signal pathways play significant role in angiogenesis wound repair burns.This study aimed to investigate preparation, characterization pharmacodynamics of total flavonoids composite phospholipids liposome Oxytropis falcata Bunge (TFOFB-CPL) on II° burns research its biological activity underlying mechanism....
Summary Formaldehyde ( FA ), a common environmental contaminant, has toxic effects on the central nervous system CNS ). We have previously found that hydrogen sulphide (H 2 S), third endogenous gaseous mediator, protects neuron against toxicity of . However, underlying mechanism is poor. Aldehyde‐dehydrogenase‐2 ALDH 2) plays major role in detoxification reactive aldehyde range organs and cell types. Therefore, we speculated H S antagonizes ‐induced neurotoxicity by modulating 2. In present...
Abstract Alkbh5 is one of the primary demethylases responsible for reversing N6-methyladenosine (m 6 A) modifications on mRNAs, and it plays a crucial role in many physiological pathological processes. Previous studies have shown that required maintaining function leukemia stem cells but dispensable normal hematopoiesis. In this study, we found deletion led to moderate increase number multiple progenitor cell populations while compromising long-term self-renewal capacity hematopoietic...
Zinc finger protein 521 (Zfp521), a quiescent hematopoietic stem cell (HSC)-enriched transcription factor, is involved in the self-renewal and differentiation of fetal liver HSC. However, its role adult hematopoiesis remains elusive. Here, we found that Zfp521 deletion did not inhibit under homeostatic conditions. In contrast, Zfp521-null chimeric mice showed significantly reduced pool size HSC progenitor cells associated with increased apoptosis loss quiescence. Competitive serial...
Energy loss of 0.45-5.0 MeV 4He ions in Au and Ag films were measured with the Rutherford backscattering method, stopping powers at lower energy range extracted by comparing that determined Anderson et al. higher range. Significant deviation between experimental data semiempirical calculations TRIM-90 appears around maximum. The accuracy our results was expected to be ±1%.