A5101691151- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Myasthenia Gravis and Thymoma
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Antiplatelet Therapy and Cardiovascular Diseases
- Epilepsy research and treatment
- Botulinum Toxin and Related Neurological Disorders
- Amyotrophic Lateral Sclerosis Research
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Inflammatory Myopathies and Dermatomyositis
- Parkinson's Disease Mechanisms and Treatments
- Peripheral Artery Disease Management
- Neurological Complications and Syndromes
- Neurogenetic and Muscular Disorders Research
- Cerebral Palsy and Movement Disorders
- Peripheral Neuropathies and Disorders
- Patient-Provider Communication in Healthcare
- Parkinson's Disease and Spinal Disorders
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Northeast Petroleum University
2025
Deleted Institution
2024
Nanjing General Hospital of Nanjing Military Command
2023
Nanjing University
2022-2023
Academy of Medical Sciences
2019-2023
Dalian Maritime University
2018-2022
Nanjing Medical University
2022
UNSW Sydney
2019
Stroke is common during the first few weeks after a transient ischemic attack (TIA) or minor stroke. Combination therapy with clopidogrel and aspirin may provide greater protection against subsequent stroke than alone.In randomized, double-blind, placebo-controlled trial conducted at 114 centers in China, we randomly assigned 5170 patients within 24 hours onset of high-risk TIA to combination (clopidogrel an initial dose 300 mg, followed by 75 mg per day for 90 days, plus 21 days) placebo...
Background As a leading cause of severe disability and death, stroke places an enormous burden on the health care system in China. There are limited data pattern current medical practice quality delivery for patients at national level. Aim The nation-wide prospective registry, China National Stroke Registry, will be considered with regard to its design, progress, geographic coverage, hospital patient characteristics. Methods Between September 2007 August 2008, Registry recruited consecutive...
Interictal epileptiform discharge (IED) and its spatial distribution are critical for the diagnosis, classification, treatment of epilepsy. Existing publicly available datasets suffer from limitations such as insufficient data amount lack information. In this paper, we present a comprehensive EEG dataset containing annotated interictal epileptic 84 patients, each contributing 20 minutes continuous raw recordings, totaling 28 hours. IEDs states consciousness (wake/sleep) were meticulously by...
There were limited data on the long-term outcome of patients with symptomatic intracranial atherosclerotic stenosis ≥70% after Wingspan stenting. Using our cohort and from Warfarin Aspirin for Symptomatic Intracranial Atherosclerotic Disease (WASID) as a historical control, we tested hypothesis that stenting provided no benefit over antithrombotic therapy alone these high-risk patients.Between January 2007 February 2009, 100 consecutive symptoms within 90 days enrolled into this prospective...
Background Dl-3-n-butylphthalide (NBP), first isolated from the seeds of celery, showed efficacy in animal models stroke. This study was a clinical trial to assess and safety NBP with continuous dose regimen among patients acute ischemic Methods A randomized, double-blind, double-dummy enrolled 573 within 48 hours onset stroke China. Patients were randomly assigned receive 14-day infusion followed by an capsule, 14- day aspirin, or ozagrel aspirin. The measures Barthel index score modified...
Polydimethylsiloxane (PDMS) could be used to improve the antifouling properties of fouling release coatings based on polyurethane (PU). A series polydimethylsiloxane-modified were synthesized with various PDMS contents, using solvent-free method. The effects content and seawater immersion chain structure surface morphology investigated by confocal laser scanning microscopy (CLSM), atomic force (AFM), Fourier transform infrared spectroscopy (FTIR), differential calorimetry (DSC),...
Background: Patients with Crohn’s disease (CD) undergoing bowel resection often suffer from depression and acute pain, which severely impairs their recovery. We aimed to investigate the effects of S-ketamine preconditioning on postoperative in patients CD a mild moderate observe whether it can relieve pain anti-inflammation. Methods: A total 124 adult were randomized into one two groups. group received 0.25 mg/kg intravenous drip under general anesthesia induction, followed by continuous...
Background Although increasing evidence suggests that hyperglycemia following acute stroke adversely affects clinical outcome, whether the association between glycaemia and functional outcome varies patients with\without pre-diagnosed diabetes remains controversial. We aimed to investigate relationship fasting blood glucose (FBG) 6-month in a subgroup of SMART cohort further assess this varied based on status diabetes. Methods Data 2862 with ischemic (629 diabetics) enrolled from were...
Energy and water are interlinked inseparable resources of vital importance to the survival development human society. Exploring relationship between energy is great practical significance for sustainable resources. The uneven regional distribution in China has exacerbated energy-related shortages. Base on footprint (WFE), this paper takes Northeast China, old industrial base, as research object, explores characteristics trend WFE, so provide quantitative basis transformation coordination...
Objective: To detect potential pathogens including pseudorabies virus in patients with encephalitis of unknown etiology China and describe novel encephalitic entities. Methods: Patients clinically suspected infectious were enrolled a multicenter study to identify the PUMCH Encephalitis Program.Next-generation sequencing(NGS) cerebrospinal fluid (CSF) was used from 2016 2017.The diagnosed as PRV studied this entity. Results: The four patients(3 male, 1 38-54 years old) had occupational...
Background and Purpose—Early presentation is critical for receiving effective reperfusion therapy acute ischemic stroke, therefore, we undertook a national survey of awareness responses to stroke symptoms in China. Methods—We cross-sectional community-based study 187 723 adults (age ≥40 years) presenting 69 administrative areas across China between January 2017 May determine the recognition rate correct action rate. Multivariable logistic regression models were used identify factors...
To evaluate the sensitivity of electrophysiologic assessments, we compared F-waves and motor sensory nerve conduction studies (MNCS SNCS) in patients with diabetes mellitus (DM).We tested median, ulnar, tibial, fibular nerves 132 DM divided into those without clinical evidence polyneuropathy.Of 64 asymptomatic patients, 2 (3%) had MNCS or SNCS abnormalities, both whom F-wave changes, whereas 21 (33%) only delayed F-waves, for a combined yield 23 (36%). The corresponding values 68 symptomatic...
Positioning a patient lying-flat in the acute phase of ischaemic stroke may improve recovery and reduce disability, but such possibility has not been formally tested randomised trial. We therefore initiated Head Position Stroke Trial (HeadPoST) to determine effects (0°) compared with sitting-up (≥ 30°) head positioning first 24 hours hospital admission for patients stroke.We plan conduct an international, cluster randomised, crossover, open, blinded outcome-assessed clinical trial involving...
Background The uptake of proven stroke treatments varies widely. We aimed to determine the association evidence‐based processes care for acute ischemic ( AIS ) and clinical outcome patients who participated in HEADPOST (Head Positioning Acute Stroke Trial), a multicenter cluster crossover trial lying flat versus sitting up, head positioning stroke. Methods Results Use 8 were considered: reperfusion therapy eligible patients; unit care; antihypertensive, antiplatelet, statin, anticoagulation...
To enhance deep learning-based automated interictal epileptiform discharge (IED) detection, this study proposes a multimodal method, vEpiNet, that leverages video and electroencephalogram (EEG) data. Datasets comprise 24 931 IED (from 484 patients) 166 094 non-IED 4-second video-EEG segments. The data is processed by the proposed patient detection with frame difference Simple Keypoints (SKPS) capturing patients' movements. EEG EfficientNetV2. features are fused via multilayer perceptron. We...
Capsular warning syndrome (CWS) is rare (1.5% of TIA presentations) but has a poor prognosis (7-day stroke risk 60%). Up to date, the exact pathogenic mechanism CWS not been fully understood. We report clinical presentations and high-resolution MRI (HR MRI) findings two cases with capsular symptoms. Case 1 was 63-year-old man history hypertension recurrent episodes left hemiparesis dysarthria lasting 10 ~ 30 minutes. 2 54-year-old woman repetitive transient about infarctions on DWI were...
Ischemic stroke is a leading cause of morbidity and mortality. Thrombolytic therapy improves disability survival rates; however, to be effective, it must given within 4.5 h onset. Moreover, thrombolytic frequently contraindicated. Therefore, alternative therapeutic options are required. In China, cinepazide maleate injection has been shown improve the cerebral collateral circulation further reduce in patients; very few studies investigating this have conducted date. study aimed confirm...
Background Involvement of peripheral nerves in dermatomyositis (DM) and polymyositis (PM) is less well known. In the present study we retrospectively analyzed clinical electrophysiological records hospital inpatients with a diagnosis DM or PM to investigate association DM/PM neuropathy. Methods The data diagnosed were collected Peking Union Medical College Hospital, 186 patients (118 68 PM) analyzed. Nerve conduction studies (NCSs) median nerve, ulnar posterior tibial common peroneal nerve...