A5100402619- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Sirtuins and Resveratrol in Medicine
- Hepatitis B Virus Studies
- Traditional Chinese Medicine Studies
- Birth, Development, and Health
- Acupuncture Treatment Research Studies
- Gout, Hyperuricemia, Uric Acid
- Medical Research and Treatments
- Metabolomics and Mass Spectrometry Studies
- Alkaloids: synthesis and pharmacology
- Healthcare and Venom Research
- Metabolism, Diabetes, and Cancer
- Chemical synthesis and alkaloids
- Pharmacological Effects of Natural Compounds
- Natural Compounds in Disease Treatment
- Pregnancy and preeclampsia studies
- Chronic Kidney Disease and Diabetes
- Phytochemicals and Antioxidant Activities
- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Ginseng Biological Effects and Applications
Tianjin University of Traditional Chinese Medicine
2014-2025
Georgia State University
2019-2025
Beijing Chao-Yang Hospital
2024-2025
Central South University
2016-2024
Sichuan University
2009-2024
Southwest Minzu University
2020-2024
Capital Medical University
2022-2024
Jinzhou Medical University
2023-2024
West China Hospital of Sichuan University
2009-2024
Sichuan Agricultural University
2017-2024
SIRT6 belongs to the mammalian homologs of Sir2 histone NAD+-dependent deacylase family. In rodents, deficiency leads aging-associated degeneration mesodermal tissues. It remains unknown whether human has a direct role in maintaining homeostasis To this end, we generated knockout mesenchymal stem cells (hMSCs) by targeted gene editing. SIRT6-deficient hMSCs exhibited accelerated functional decay, feature distinct from typical premature cellular senescence. Rather than compromised chromosomal...
Sir2, a NAD-dependent deacetylase, modulates lifespan in yeasts, worms and flies. The SIRT1, mammalian homologue of regulates signaling for favoring survival stress. But whether SIRT1 has the function to influence cell viability senescence under non-stressed conditions human diploid fibroblasts is far from unknown. Our data showed that enforced expression promoted proliferation antagonized cellular with characteristic features delayed Senescence-Associated beta-galactosidase (SA-beta-gal)...
Kadsua coccinea (K. coccinea) has long been used as a fruit and folk medicine; however, the composition of its leaves activities constituents have seldom studied. A total 98 chemical constituents, including 53 phenolic acids, 41 flavonoids, 4 lignans, were identified from plant kadsua by UHPLC-Q-Exactive Orbitrap Mass spectrometry. All these chemicals reported for first time in leaves, 95 them coccinea. The biological potential extracts K. (EKL) was evaluated vitro antioxidant assay...
IDO1 (indoleamine 2,3-dioxygenase 1) is the rate-limiting enzyme for tryptophan metabolism. malfunction involved in pathogenesis of atherosclerosis. Vascular smooth muscle cells (VSMCs) with an osteogenic phenotype promote calcification and features plaque instability. However, it remains unclear whether aberrant IDO1-regulated metabolism causes VSMCs reprogramming calcification.
Background Environmental alternations leading to fetal programming of cardiovascular diseases in later life have been attributed maternal factors. However, animal studies showed that paternal obesity may program cardio-metabolic the offspring. In current study we tested hypothesis BMI be associated with growth. Methods and Results We analyzed relationship between body mass index (BMI) birth weight, ultrasound parameters describing newborn's shape as well newborns endocrine system such...
Objective: Mangiferin (MGF) is a natural xanthone, with regulation effect on lipid metabolism. However, the molecular mechanism remains unclear. We purposed after oral administration, MGF converted to its active metabolite(s), which contributes effects Methods: KK-Ay mice were used validate of metabolic disorders. Liver biochemical indices and gene expressions determined. metabolites isolated from administrated rat urine. Mechanism studies carried out using HepG2 cells treated by metabolite...
Objective: Salvia miltiorrhiza (Danshen) has been widely used for the treatment of cardiac and cerebrovascular disease throughout history. The objective this study is to further elucidate mechanisms underlying Danshen’s protective effects support its clinical evidence. Methods Results: Salvianolic acid B (Sal B) Tanshinone IIA (Tan IIA) are two major components in Danshen. We observed that Sal Tan have cardioprotective an vivo myocardial infarction model C57 mice, vasodilator action a ex...
Summary Fusaric acid ( FSA ) is a phytotoxin produced by several Fusarium species and has been associated with plant disease development, although its role still not well understood. Mutation of key genes in the biosynthetic gene FUB cluster oxysporum f. sp. cubense tropical race 4 Foc TR 4) reduced production, resulted decreased symptoms fungal biomass host banana plants. When pretreated , both leaves pseudostems exhibited increased sensitivity to invasion. Banana embryogenic cell...
Lycorine is a multifunctional bioactive compound, and it possesses potential anticancer activities. However, little known about the underlying mechanism. In this research, we have found that lycorine significantly induces apoptotic autophagic capacities of hepatocellular carcinoma (HCC) cells in vitro vivo Treatment with specific autophagy inhibitor (3-methyladenine/Bafilomycin A1) or knockdown LC-3B/Atg5 by siRNA drastically enhances cell death effect facilitating switch from to apoptosis....
Although mitochondria are known to be involved in host defense against viral infection, the physiological role of mitophagy, a crucial mechanism for maintaining mitochondrial homeostasis, antiviral immunity remains poorly defined. Here, we show that Parkin, central player has vital function regulating responses. Parkin-knockout mice exhibit improved clearance and survival after infection. However, Parkin deficiency does not affect signaling interferon production. Instead, augments innate...
(+)- and (-)-Lesinurad were isolated as atropisomers from racemic lesinurad for the first time. No interconversion was observed between two under various conditions tested. The showed significant differences in hURAT1 highly expressed HEK293 cell-based inhibition assays, monkey pharmacokinetic studies, vitro human recombinant CYP2C9 stability studies. It speculated that (+)-lesinurad might offer a better hyperuricemia/gout therapy than (-)-lesinurad or racemate.