A5013115102- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Phytochemicals and Antioxidant Activities
- Plant-based Medicinal Research
- Nanomaterials for catalytic reactions
- Recycling and Waste Management Techniques
- Supercapacitor Materials and Fabrication
- Chromatography in Natural Products
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Metabolomics and Mass Spectrometry Studies
- Ubiquitin and proteasome pathways
- Polysaccharides and Plant Cell Walls
- Pharmacological Effects of Natural Compounds
- Essential Oils and Antimicrobial Activity
- Cancer therapeutics and mechanisms
- Polysaccharides Composition and Applications
- Cancer-related Molecular Pathways
- Curcumin's Biomedical Applications
- Bioactive Compounds and Antitumor Agents
- Morinda citrifolia extract uses
- Advanced Cellulose Research Studies
- Phytochemical and Pharmacological Studies
- Biological Activity of Diterpenoids and Biflavonoids
Zhejiang University
2021-2025
Hunan University
2020-2024
Weifang Medical University
2022-2024
Chongqing University
2019-2024
Fudan University
2024
Fujian Agriculture and Forestry University
2023-2024
Collaborative Innovation Center of Chemistry for Energy Materials
2024
Chengdu University of Technology
2023
Hunan University of Traditional Chinese Medicine
2022-2023
Second Hospital of Shandong University
2014-2020
The practical application of aqueous zinc-ion batteries (AZIBs) is greatly challenged by rampant dendrites and pestilent side reactions resulting from an unstable Zn–electrolyte interphase. Herein, we report the construction a reliable superstructured solid electrolyte interphase for stable Zn anodes using mesoporous polydopamine (2D-mPDA) platelets as building blocks. shows biomimetic nacre's "brick-and-mortar" structure artificial transmembrane channels hexagonally ordered mesopores in...
Kadsua coccinea (K. coccinea) has long been used as a fruit and folk medicine; however, the composition of its leaves activities constituents have seldom studied. A total 98 chemical constituents, including 53 phenolic acids, 41 flavonoids, 4 lignans, were identified from plant kadsua by UHPLC-Q-Exactive Orbitrap Mass spectrometry. All these chemicals reported for first time in leaves, 95 them coccinea. The biological potential extracts K. (EKL) was evaluated vitro antioxidant assay...
Catalytic upcycling of polyolefins into high-value chemicals represents the direction in end-of-life plastics valorization, but poses great challenges. Here, we report synthesis a tandem porous catalyst via micelle cascade assembly strategy for selectively catalytic cracking polyethylene olefins at low temperature. A hierarchically silica layer from mesopore to macropore is constructed on surface microporous ZSM-5 nanosheets through dynamic micelles. The outer arrays can adsorb bulky quickly...
Arnebiae Radix (dried root of Arnebia euchroma (Royle) Johnst.) has been used in traditional Chinese medicine (TCM) to treat macular eruptions, measles, sore throat, carbuncles, burns, skin ulcers, and inflammation. Previous studies have shown that shikonins shikonofurans are two their main bioactive ingredients. However, systematic investigations constituents rarely conducted. It is necessary establish a rapid effective method identify the chemical Radix. This will help further improve...
The tedious synthesis and limited throughput biological evaluation remain a great challenge for discovering new proteolysis targeting chimera (PROTAC). To rapidly identify potential PROTAC lead compounds, we report platform named Auto-RapTAC. Based on the modular characteristic of molecule, streamlined workflow that integrates lab automation with "click chemistry" joint building-block libraries was constructed. This facilitates autonomous generation variety PROTACs, each distinct linkers E3...
Introduction The bioactive compound 3,5-DiCQA, derived from Duhaldea nervosa, has been traditionally utilized in folk remedies for bone fractures and osteoporosis. However, its therapeutic mechanisms remain unclear. Methods We employed UHPLC-Q Exactive Orbitrap MS-based cell metabolomics to investigate the molecular of 3,5-DiCQA MC3T3-E1 cells. Cell proliferation was assessed via MTT assay, differentiation by alkaline phosphatase (ALP) activity, mineralization through alizarin red staining...
Duhaldea nervosa (Wallich ex Candolle) A. Anderberg was widely used for food spice and folk medicine. However, it is still insufficient in the constituent's characterization of D. nervosa. In this study, a systematic strategy rapid detection identification constituents proposed based on UHPLC-Q-Exactive Orbitrap mass spectrometry parallel reaction monitoring mode combining anion exchange resin separation, expected compounds predicted diagnosis fragmentation ions techniques. Finally, 149...
Paeoniae Radix Alba (PRA, dried root of Paeonia lactiflora Pall.) is a widely used as traditional Chinese medicine and tannins are one their main bioactive ingredients. However, there rarely systematically investigated in this study. This study aimed to establish rapid, high selective, sensitive effective method based on UHPLC-Q-Exactive Orbitrap MS for simultaneous identification the PRA. Separation was performed Thermo Scientific Hypersil GOLD™ aQ (100 mm × 2.1 mm, 1.9 μm) using gradient...
The purpose of this study is to identify and quantify the chlorogenic acids (CGAs) from root bark Acanthopanax gracilistylus, which conventionally regarded as a tonic in folk Chinese Traditional medicine. effective methods for identification quantification analysis CGAs were developed based on ultra high performance liquid chromatography-Q-exactive orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS) parallel reaction monitoring (PRM) selected (SIM), showed sensitivity resolution screening...
Diacerein, a competently semisynthetic diacetyl derivative of anthraquinone, is nonsteroidal anti-inflammatory drug, which has been used for treating osteoarthritis and preventing vascular diseases. However, previous investigation indicated that diacerein metabolites its metabolic pathway in vivo was still unclear. In this research, an effective method established based on ultra-high-performance liquid chromatography coupled with Q-Exactive-Orbitrap mass spectrometer molecular docking to...
Inula cappa (Buch.-Ham. ex D. Don) DC has been used in traditional Chinese medicine to treat malaria, dysentery, and hepatitis. Previous studies have shown that chlorogenic acid is the effective ingredient of plants this family. And research will help further improve resource utilization rate plant. Therefore, it necessary establish an accurate method characterize components cappa. In study, a simple, fast, sensitive UHPLC-Q-Exactive Orbitrap mass spectrometry was established, which can...
Abstract Catalytic upcycling of polyolefins into high‐value chemicals represents the direction in end‐of‐life plastics valorization, but poses great challenges. Here, we report synthesis a tandem porous catalyst via micelle cascade assembly strategy for selectively catalytic cracking polyethylene olefins at low temperature. A hierarchically silica layer from mesopore to macropore is constructed on surface microporous ZSM‐5 nanosheets through dynamic micelles. The outer arrays can adsorb...
Aurantio-obtusin (AO) is a major anthraquinone compound isolated from Cassiae Semen or Duhaldea nervosa, which possesses diverse pharmacological effects. Previous studies have shown that it has good effect on lowering blood lipids and treating various diseases. A few also reported about its metabolites. rapid reliable method using ultra-high-performance liquid chromatography-Q-Exactive Orbitrap mass spectrometry multiple data-processing technologies was established to investigate the...
Content Isochlorogenic acid A, one of the main components Duhaldea nervosa (Wallich ex Candolle) A. Anderberg (Asteraceae), is a folk medicine used to treat variety diseases including fracture and rheumatoid arthritis. Despite its widespread use, metabolism isochlorogenic A in vivo has not been fully studied.Objective An analytical strategy based on UHPLC-Q-Exactive Orbitrap MS proposed for detection identification metabolites rats.Materials methods Six male Sprague-Dawley rats (180 ± 20 g)...
Qingqiao Kangdu granule (QQKDG), a traditional Chinese medicine (TCM), has been used clinically to treat various viral diseases, including flu, mumps, and hepatitis, owing its abundant bioactivities. Nevertheless, the chemical components of QQKDG have not sufficiently elucidated; consequently, development standards for quality evaluation complete understanding pharmacological mechanisms action are hindered. Therefore, systematic approach must be developed efficiently discover novel compounds...