A5100405153- Galectins and Cancer Biology
- Retinal Imaging and Analysis
- Cancer therapeutics and mechanisms
- Retinal Diseases and Treatments
- Ophthalmology and Visual Impairment Studies
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Retinal and Optic Conditions
- Endometrial and Cervical Cancer Treatments
- Drug Transport and Resistance Mechanisms
- Toxin Mechanisms and Immunotoxins
- Hepatocellular Carcinoma Treatment and Prognosis
- Thyroid and Parathyroid Surgery
- Effects of Radiation Exposure
- Bladder and Urothelial Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer, Lipids, and Metabolism
- Multiple Myeloma Research and Treatments
- Hepatitis B Virus Studies
- Cancer-related Molecular Pathways
- 14-3-3 protein interactions
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Liver Disease Diagnosis and Treatment
Southern Medical University
2021-2024
Shenzhen University
2024
Central South University
2024
Fuzhou University
2024
Fujian Provincial Hospital
2024
Fujian Medical University
2021-2024
Guangzhou Medical University
2009-2024
Second Xiangya Hospital of Central South University
2024
The First People's Hospital of Shunde
2024
China Pharmaceutical University
2023
retinal age derived from fundus images using deep learning has been verified as a novel biomarker of ageing. We aim to investigate the association between gap (retinal age-chronological age) and incident Parkinson's disease (PD).a (DL) model trained on 19,200 11,052 chronic disease-free participants was used predict age. Retinal generated by DL for remaining 35,834 free PD at baseline assessment. Cox proportional hazards regression models were utilised PD. Multivariable logistic applied...
Abstract Background The aim of this study is to investigate the association retinal age gap with risk incident stroke and its predictive value for stroke. Methods A total 80,169 fundus images from 46,969 participants in UK Biobank cohort met image quality standard. deep learning model was constructed based on 19,200 11,052 disease-free at baseline prediction. Retinal (retinal predicted minus chronological age) generated remaining 35,917 participants. Stroke events were determined by data...
Abstract A1874 is a novel BRD4-degrading proteolysis targeting chimera (PROTAC). In primary colon cancer cells and established HCT116 cells, potently inhibited cell viability, proliferation, cycle progression, as well migration invasion. The PROTAC was able to induce caspase apoptosis activation in cells. Furthermore, A1874-induced degradation of BRD4 protein downregulated BRD-dependent genes ( c-Myc , Bcl-2 cyclin D1 ) Significantly, anti-colon activity more potent than the known inhibitors...
Background: Microsatellite instability (MSI) is associated with treatment response and prognosis in patients rectal cancer (RC). However, intratumoral heterogeneity limits MSI testing RC. We developed a subregion radiomics model based on multiparametric magnetic resonance imaging (MRI) to preoperatively assess high-risk subregions predict the status of Methods: This retrospective study included 475 (training cohort, 382; external test 93) RC from two participating hospitals between April...
Galectin-1 is a lectin recognized by galactoside-containing glycoproteins, and involved in cancer progression metastasis. The role of galectin-1 radiosensitivity has not previously been investigated. Therefore, this study tests whether the mediated H-Ras signaling pathway using cervical carcinoma cell lines. A knockdown expression HeLa cells decreased clonogenic survival following irradiation. increased both C33A with overexpression. overexpression or did alter radiosensitivity, whereas was...
Background: The CD4 T-lymphocyte (CD4) count is a critical biomarker for HIV disease progression and immune health, that essential guiding treatment decisions. However, quantitative assessment of the impact rapid decline on AIDS pre-AIDS death remains unclear. Methods: This study includes 11,647 HIV-positive patients from Zhejiang Provincial Center Disease Control Prevention (CDC) 2005 to 2017. longitudinal trajectory extremely low counts captured by generalized Pareto (GP) model, jointly...
Abstract Introduction: Bispecific T-cell engagers (BiTEs) are innovative cancer therapeutics designed to harness the immune system by linking T cells cells, inducing tumor-specific cytotoxicity, which enhances specificity and reduces off-target effects on normal tissue. In this study in vitro assays were established evaluate tumor cell-killing cell activation of BiTEs, specifically using a claudin18.2-targeted BiTE AMG910 monoclonal antibody zolbetuximab. Methods: Target expression for...
Alectinib, an inhibitor of anaplastic lymphoma kinase (ALK), was approved by the Food and Drug Administration (FDA) for treatment patients with ALK-positive non-small cell lung cancer (NSCLC). Here we investigated reversal effect alectinib on multidrug resistance (MDR) induced ATP-binding cassette (ABC) transporters, which is primary cause chemotherapy failure. We provide first evidence that increases sensitivity ABCB1- ABCG2-overexpressing cells to chemotherapeutic agents in vitro vivo....
Abstract Background Dual sensory impairment is affecting over 10% of older adults worldwide. However, the long-term effect dual (DSI) on risk mortality remains controversial. We aim to investigate impact single or/and in a large population-based sample adult UK with 14-years follow-up. Methods This prospective cohort study included participants aged 40 and complete records visual hearing functions from Biobank study. Measurements were performed at baseline examinations between 2006 2010,...
Menopausal women may experience menopausal syndrome and long-term effects caused by low estrogen levels, such as senile dementia osteoporosis in the elderly. Most have misconceptions about menopause use of pharmacological interventions. These damage quality life miss critical period for preventing diseases. Thus, enhancing awareness regarding psychosocial physical changes through health education programs was a way to improve positive attitudes toward make further treatment options. This...
KRAS mutations are associated with poor prognosis in colorectal cancer (CRC). Although the association between gut microbiota and CRC has been extensively documented, it is unclear whether can regulate microbiota. Metagenomics identified changes diversity of due to mutations. Specifically, positively correlate abundance bacteroides. Understanding how classic carcinogenic bacterium within bacteroides, such as enterotoxigenic bacteroides fragilis (ETBF), enhance treatment efficacy tumors a key...
// Eng-Yen Huang 1 , 2 5 * Feng-Sheng Wang 3, 4, Yu-Min Chen Yi-Fan Chung-Chi I-Hui Lin Yu-Jie Kuender D. Yang 6, 7 Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, University College Medicine, 123 Ta-Pei Road, Niao-Sung District, 833, Taiwan Graduate Institute Clinical Medical Sciences, 3 Research, 4 Center for Laboratory Animals, School Traditional Chinese 6 Show Chwan Hospital in Bing, 6-1 Lu-Kung Bing Industrial Center, Lu-Kang, Changhua 505, National Ming...
AFB 1 is a potent recombinagen in budding yeast. exposure induces RAD51 expression and triggers Rad53 activation yeast cells that express human CYP1A2. It was unknown, however, when if Rad51 foci appear. Herein, we show correlates with cell‐cycle delay the subsequent formation of foci. In contrast to exposed X‐rays, which appear exclusively G2 cells, ‐exposed can as soon enter S phase. Although rad51 rad4 mutants are mildly sensitive , chronic NER deficient leads increased lag times, while...
// Fang Wang 1, 2, * , Yifan Chen Lihua Huang Tao Liu 1 Yue Jianming Zhao Xiaokun 2 Ke Yang Shaolin Ma Liyan Kenneth Kin Wah To 3 Yong Gu 4 Liwu Fu Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Center, Guangzhou, China Guangdong Esophageal Institute, School Pharmacy, the Chinese Hong Kong, Department Thoracic Surgery, First Affiliated Hospital University, Province, These authors have contributed equally to this...
Objective: The objective of the study was to investigate whether hepatocellular carcinoma (HCC) histology is associated with clinical and computed tomographic/magnetic resonance imaging features locoregional therapy (LRT) outcomes. Subjects Methods: This single-center retrospective included 124 consecutive patients (92 men, median age 59 years) 132 HCC diagnosed by biopsy between 2008 2017 before LRT. Patients underwent chemoembolization ( n = 51, 41%), ablation 41, 33%), yttrium-90...
Bladder cancer is one of the most common carcinomas and it brings about huge social economic burden. There not a reliable way to predict prognosis bladder patients. We develop nomogram patients.A total 127 patients after radical cystectomy were studied retrospectively. Their clinicopathological data collected for statistical analysis.The level albumin/globulin ratio (AGR), C-reactive protein/albumin (CAR), neutrophil lymphocyte (NLR) platelet (PLR) associated with pathological hematological...
The purpose of this study was to evaluate the feasibility radiofrequency ablation (RFA) for thyroid nodules with cytological atypia undetermined significance or follicular lesion (AUS/FLUS, Bethesda III).A total 28 adults presenting 30 initial III underwent RFA at a single medical center. Thyroid IV V according second aspiration were excluded. All procedures performed using free-hand, 'moving-shot' technique under local anesthesia. Clinical features and demographics, details, nodule volume...