A5100431991- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Glycation End Products research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immune Response and Inflammation
- Respiratory Support and Mechanisms
- Genetic Syndromes and Imprinting
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Plant-based Medicinal Research
- Pediatric health and respiratory diseases
- Chromatography in Natural Products
- Neonatal Respiratory Health Research
- Reproductive Biology and Fertility
- Intensive Care Unit Cognitive Disorders
- Immune Cell Function and Interaction
- Treatment of Major Depression
- Immune cells in cancer
- Kruppel-like factors research
- Dermatology and Skin Diseases
- Ginkgo biloba and Cashew Applications
- Flavonoids in Medical Research
- Nuclear Receptors and Signaling
- Advanced Research in Science and Engineering
- Phagocytosis and Immune Regulation
- Invertebrate Immune Response Mechanisms
The First People's Hospital of Shunde
2022-2024
Southern Medical University
2012-2024
Hunan Normal University
2004-2024
Affiliated Hospital of Southwest Medical University
2024
Hunan Provincial People's Hospital
2020-2023
Nanfang Hospital
2018-2023
Weatherford College
2021-2023
Philipps University of Marburg
2023
Guangdong Academy of Medical Sciences
2023
Guangdong Provincial People's Hospital
2023
Vacuolar protein sorting-35 (VPS35) is essential for endosome-to-Golgi retrieval of membrane proteins. Mutations in the VPS35 gene have been identified patients with autosomal dominant PD. However, it remains poorly understood if and how deficiency or mutation contributes to PD pathogenesis. Here we provide evidence that links PD-like neuropathology. was expressed mouse dopamine (DA) neurons substantia nigra pars compacta (SNpc) STR (striatum)--regions are vulnerable. VPS35-deficient mice...
Objective Checkpoint immunotherapy unleashes T-cell control of tumours but is suppressed by immunosuppressive myeloid cells. The transmembrane protein MS4A4A selectively highly expressed in tumour-associated macrophages (TAMs). Here, we aimed to reveal the role + TAMs regulating immune escape tumour cells and develop novel therapeutic strategies targeting enhance efficacy checkpoint inhibitor (ICI) colorectal cancer. Design inhibitory effect blockade alone or combined with ICI treatment on...
Mitogen-activated protein kinase (MAPK) signaling pathways are implicated in inflammatory and apoptotic processes of cerebral ischemia reperfusion (I/R) injury. Hence, MAPK represent a promising therapeutic target. Exploring the full potential inhibitors is useful strategy for ischemic stroke. Bilobalide, predominant sesquiterpene trilactone constituent Ginkgo biloba leaves, has been shown to exert powerful neuroprotective properties, which closely related both anti-inflammatory...
As a damage-associated molecular pattern molecule, high-mobility group box 1 (HMGB1) is well-studied and released from injured tubular epithelial cells to trigger cell death. However, the role of intracellular HMGB1 induced death during acute kidney injury (AKI) poorly understood. We showed that cytosolic ferroptosis by binding acyl-CoA synthetase long-chain family member 4 (ACSL4), driver ferroptosis, following renal ischemia/reperfusion (I/R). Both mouse human kidneys with were...
ObjectivesTo describe the epidemiology, microbiology and management of invasive Candida infection (ICI) in intensive care units (ICUs) China.
Background: Microsatellite instability (MSI) is associated with treatment response and prognosis in patients rectal cancer (RC). However, intratumoral heterogeneity limits MSI testing RC. We developed a subregion radiomics model based on multiparametric magnetic resonance imaging (MRI) to preoperatively assess high-risk subregions predict the status of Methods: This retrospective study included 475 (training cohort, 382; external test 93) RC from two participating hospitals between April...
Background : Surfactant protein D (SP-D) is a lung-specific proposed to predict clinical outcomes in patients with chronic obstructive pulmonary disease (COPD). However, the changes serum SP-D during acute exacerbation (AECOPD) episodes and relationship of overall severity stable COPD (SCOPD) remain unclear. Methods Serum levels were analyzed three groups, including AECOPD ( n =40), SCOPD =71), controls =60). In group, determined at 1, 5, 14, 30 days post-exacerbation. BODE (body mass index,...
Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus. Patients with LN mostly die sclerosing glomerulonephritis and renal failure. The inhibition glomerular mesangial matrix deposition an efficient method to restrict progress injury. By recognizing binding extracellular intracellular ligands, Toll-like receptor 2 (TLR2) contributes pathogenesis immune diseases. However, relationship between TLR2 still unknown. Our previous studies confirmed that high-mobility...
Human spermatogonial stem cells (SSCs) are essential for spermatogenesis and male fertility. However, molecular mechanisms regulating fate determinations of human SSCs remain elusive. In this study, we revealed that KLF2 decreased the proliferation, DNA synthesis, colonization as well increased apoptosis these cells. We identified demonstrated GJA1 was a target gene in SSCs. Notably, overexpression rescued reduction proliferation caused by silencing enhancement Abnormalities higher level and/or
About half or more of treatment-resistant depressed patients do not respond to ketamine, and few clinical predictors gauge the most likely antidepressant response have been proposed. We explored whether depression subtypes are associated with ketamine.Ninety-seven participants were administered six repeated-dose intravenous ketamine assessed for (Montgomery-Åsberg Depression Rating Scale, MADRS), anxiety (Hamilton Anxiety HAMA), suicidal ideation (Beck Scale Suicidal Ideation, SSI) at...
Objective As an important biomarker to reflect tumor cell proliferation and aggressiveness, Ki-67 is closely related the high early recurrence rate poor prognosis, pretreatment evaluation of expression possibly provides a more accurate prognosis assessment better treatment plan. We aimed develop nomogram based on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) combined with T1 mapping predict in hepatocellular carcinoma...
A rapid, specific and sensitive method was developed for the simultaneous determination of eight Aconitum alkaloids: aconitine (AC), mesaconitine (MA), hypaconitine (HA), benzoylaconine (BAC), benzoylmesaconine (BMA), benzoylhypaconine (BHA), aconine mesaconine in rat blood by ultra-performance liquid chromatography coupled tandem mass spectrometry (UPLC-MS/MS).
This study was designed to determine the expression of serum and sputum surfactant protein D (SP‑D) in chronic obstructive pulmonary disease (COPD) its association with treatment response. Sixty‑five treatment‑naive patients COPD 26 normal control subjects were recruited study. The concentrations SP‑D measured, associations function modified Medical Research Council dyspnea scale (mMRC) St. George's Respiratory Questionnaire (SGRQ) scores before after three months an inhaled corticosteroid a...
The present study aimed to investigate the protective mechanism of ulinastatin against lung injury. Rat models with chronic obstructive pulmonary disease (COPD) were used provide guidance for medical treatment this disease. rats divided into three groups: A control group, a model group and an experimental (each, n=10). With exception all prepared as COPD, using composite molding method smoking intratracheal instillation lipopolysaccharide. in received conventional treatment, while...
According to the United Nations, access medical care is a fundamental human right. However, there widespread stigmatization of severe mental illnesses and this appears seriously hamper quality healthcare in people with psychiatric co-morbidity. Thus, interventions that help reduce stigma among providers are urgently needed.The objective current study was investigate effects clerkship on stigmatizing attitudes toward disorders held by students.Between 2018 2019, total 256 third- fourth-year...
To select the core target (RAB13) in sepsis patients' peripheral blood and investigate its molecular functions possible mechanisms. The of patients (n = 21) healthy individuals 9) within 24 h after admission were collected for RNA-seq, differential gene screening was performed by iDEP online analysis software (P < 0.01; log2FC ≥ 2) enrichment analysis, potential RAB13 screened out. association between expression severity explored using multiple datasets GEO database, survival conducted....
Emerging studies demonstrated that IL-33 and its receptor ST2 acted as a key factor in inflammatory disease. Besides, accumulating evidences evaluated the cytokines TNF-α IL-1β could trigger cascade. Importantly, SIRT1 were validated to suppress expression of cytokines. However, whether effects on IL-33/ST2 signaling initiates cascade via modulating remain unclear. In present study, we found DRG upregulated SNI rats intrathecal injection either antibody or alleviated mechanical allodynia...