A5100607297- Zebrafish Biomedical Research Applications
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Acute Myeloid Leukemia Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gold and Silver Nanoparticles Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Aquaculture disease management and microbiota
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Platelet Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- MicroRNA in disease regulation
- Erythrocyte Function and Pathophysiology
- Periodontal Regeneration and Treatments
- Metabolomics and Mass Spectrometry Studies
- Hematopoietic Stem Cell Transplantation
- Antibiotic Resistance in Bacteria
- Infective Endocarditis Diagnosis and Management
- Medical and Biological Ozone Research
First Affiliated Hospital of Zhengzhou University
2023
Southern Medical University
2010-2021
Jilin Normal University
2019
Chinese PLA General Hospital
2017
Guangzhou Institutes of Biomedicine and Health
2015-2016
Chinese Academy of Sciences
2015-2016
Background/Aims: Forsythia suspensa Vahl. (Oleaceae) fruits are widely used in traditional Chinese medicine to treat pneumonia, typhoid, dysentery, ulcers and oedema. Antibacterial anti-inflammatory activities have been reported for phillyrin (PHN), the main ingredient Vahl fruits, vitro. However, underlying mechanisms vivo remain poorly defined. In this study, we discovered that PHN exerted potent effects lethal LPS-induced neutrophil inflammation by suppressing MyD88-dependent signalling...
Introduction Early and effective application of antimicrobial medication has been evidenced to improve outcomes patients with bloodstream infection (BSI). However, conventional microbiological tests (CMTs) have a number limitations that hamper rapid diagnosis. Methods We retrospectively collected 162 cases suspected BSI from intensive care unit blood metagenomics next-generation sequencing (mNGS) results, comparatively evaluate the diagnostic performance clinical impact on antibiotics usage...
The hallmark of vertebrate definitive hematopoiesis is the establishment hematopoietic stem/progenitor cell (HSPC) pool during embryogenesis. This process involves a defined ontogenic switching HSPCs in successive compartments and evolutionarily conserved from teleost fish to human. In zebrafish, originate ventral wall dorsal aorta (VDA), which they subsequently mobilize an intermediate site known as caudal tissue (CHT) finally colonize kidney for adult hematopoiesis. Despite substantial...
Hematopoiesis is a progressive process collectively controlled by an elaborate network of transcription factors (TFs). Among these TFs, GATA2 has been implicated to be critical for regulating multiple steps hematopoiesis in mouse models. However, whether similar function conserved human hematopoiesis, especially during early embryonic development stage, largely unknown.To examine the role background, we generated homozygous knockout stem cells (GATA2 (-/-) hESCs) and analyzed their blood...
The transition from hemogenic endothelial cells (HECs) to hematopoietic stem/progenitor (HS/PCs), or (EHT), is a critical step during hematopoiesis. However, little known about the molecular determinants of HECs due challenge in defining HECs. We report here generation GATA2w/eGFP reporter human embryonic stem (hESCs) mark expressing GATA2, gene for EHT. show that differentiation, functional are almost exclusively GATA2/eGFP+. then constructed regulatory network HEC determination and also...
Alcoholic liver disease (ALD) is a series of abnormalities function, including alcoholic steatosis, steatohepatitis, and cirrhosis. Hesperidin, the major constituent flavanone in grapefruit, proved to play role antioxidation, anti-inflammation, reducing multiple organs damage various animal experiments. However, underlying mechanism resistance injury still unclear. Thus, we aimed investigate protective effects hesperidin against ALD its molecular this study. We established an zebrafish...
In this work, we introduced an ordered metal-semiconductor molecular system and studied the resulting surface-enhanced Raman scattering (SERS) effect. Ag-FeS nanocaps with sputtered films of different thicknesses were obtained by changing sputtering power FeS while Ag deposition time remained constant. When metallic semiconductor are cosputtered, film separates into islands partially covered strong coupling occurs among isolated FeS, which contributes to SERS phenomenon. We also investigated...
Neutrophils play essential roles in innate immunity and are the first responders to kill foreign micro-organisms, a function that partially depends on their granule content. The complicated regulatory network of neutrophil development maturation remains largely unknown. Here we utilized neutrophil-deficient zebrafish identify novel role Alas1, heme biosynthesis pathway enzyme, development. We showed Alas1-deficient exhibited proper initiation, but further was blocked due deficiency, with...
Cosputtering technology was utilized to combine Ag with ZnS at different doping contents into a new material, which referred as the (Ag)x(ZnS)y (x = 10 W, y 20, 40, 60, 80, 100 W) system. The carrier density is characterized through Hall effect, and change in bandgap distribution due calculated by ultraviolet photoelectron spectroscopy (UPS). By increasing sputtering power of system, conduction band (CB)/valence (VB) were decreased. Interestingly, we found liner relationship between...
ABSTRACT T lymphocytes are key cellular components of an acquired immune system and play essential roles in cell-mediated immunity. cell development occurs the thymus where 95% immature thymocytes eliminated via apoptosis. It is known that mutation Zeb1, one retinoblastoma 1 (Rb1) target genes, results a decrease number cells mice. E2F1, RB1-interacting protein, has been shown to regulate mature by interfering with thymocyte However, whether Rb1 regulates vivo still needs be further...
Hematopoiesis is a complicated and dynamic process about which the molecular mechanisms remain poorly understood. Danio rerio (zebrafish) an excellent vertebrate system for studying hematopoiesis developmental mechanisms. In previous study, we isolated identified cloche172 (clo172) mutant, novel allele compared to original cloche (clo) through using complementation test initial mapping. Here, according whole mount in-situ hybridization, report that endothelial cells in clo172 mutant embryos,...