A5100401877- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Circular RNAs in diseases
- RNA Research and Splicing
- Protease and Inhibitor Mechanisms
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Calpain Protease Function and Regulation
- Epigenetics and DNA Methylation
- Alcohol Consumption and Health Effects
- Ferroptosis and cancer prognosis
- Pancreatic function and diabetes
- Mechanisms of cancer metastasis
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Barrier Structure and Function Studies
- Signaling Pathways in Disease
Langfang Normal University
2024
Anhui Medical University
2024
University of California, San Diego
2022-2023
Guangdong Medical College
2023
Pudong Medical Center
2021-2022
Fudan University
2004-2022
University of Oklahoma Health Sciences Center
2018-2022
Guangdong Pharmaceutical University
2022
Creative Commons
2022
China Pharmaceutical University
2022
Abstract Purpose: PI3K and STAT3 are frequently activated in cancer progression. However, little is known about the underlying mechanisms by which regulate head neck squamous cell (HNSCC) growth. The lncRNA HOX transcript antisense RNA (HOTAIR) was found to modulate progression of HNSCC. In this study, we attempted establish correlation PI3K/STAT3/HOTAIR signaling with HNSCC its sensitivity toward platinum-based targeted anti-EGFR combination therapy. Experimental Design: We first analyzed...
Epidermal growth factor receptor (EGFR) is an essential target for cancer treatment. However, EGFR inhibitor erlotinib showed limited clinical benefit in pancreatic therapy. Here, we the underlying mechanism of tumor microenvironment suppressing sensitivity through stellate cell (PSC). The expression alpha-smooth muscle actin (α-SMA) and hypoxia marker human tissues were detected by immunohistochemistry, their correlation with overall survival was evaluated. Human immortalized PSC...
Aberrant sialylation is frequently observed in tumor development, but which sialyltransferases are involved this event not well known. Herein, we performed comprehensive analyses on six ST3GAL family members, the α-2,3 sialyltransferases, clear cell renal carcinoma (ccRCC) from public datasets. Only ST3GAL5 was consistently and significantly overexpressed ccRCC (n = 791 total), compared with normal kidney tissues. Its overexpression positively correlated stage, grade, poor prognosis...
Background and Aims . Critical roles of circulating exosomal long noncoding RNAs (lncRNAs) have been implicated in multiple diseases. However, little is known about their coronary artery disease (CAD). The aim the present study was to investigate relationships between lncRNAs CAD identify aberrantly expressed disease-related as biomarkers diagnosing CAD. Methods plasma exosomes from patients controls were identified by microarray analysis verified quantitative real-time PCR (qRT-PCR). Then,...
Abstract Background Glycolysis is critical for harvesting abundant energy to maintain the tumor microenvironment in malignant tumors. Retinoic acid-related orphan receptor α (RORα) has been identified as a circadian gene. However, association of glycolysis with RORα regulating gastric cancer (GC) proliferation remains poorly understood. Methods Bioinformatic analysis and retrospective study were utilized explore role cell cycle GC. The mechanisms performed vitro vivo including colony...
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Alcoholic liver disease (ALD) is a series of abnormalities function, including alcoholic steatosis, steatohepatitis, and cirrhosis. Hesperidin, the major constituent flavanone in grapefruit, proved to play role antioxidation, anti-inflammation, reducing multiple organs damage various animal experiments. However, underlying mechanism resistance injury still unclear. Thus, we aimed investigate protective effects hesperidin against ALD its molecular this study. We established an zebrafish...
Long noncoding RNA (lncRNA) DUXAP10 has been shown to act as an oncogene in various tumors; however, its roles glioma progression have never established. Here, we show that is overexpressed tissues and cells. Loss of function experiments reveal knockdown little effects on cell viability, but significantly reduces the stemness cells, which characterized decrease marker expression, tumor sphere-forming ability, ALDH activity. immunoprecipitation immunofluorescence assays indicate can directly...
Long non-coding (lncRNA) neuroblastoma highly expressed 1 (NHEG1) has been reorganized as a prognostic factor in (NB), but the molecular mechanisms suppression of remain to be elucidated. In our study, we explored functional roles lncRNA NHEG1 and underlying mechanism. We collected NB tumor samples adjacent normal tissues compare expression. Through bioinformatic target prediction, selected potential downstream effectors for validation cell lines. observed that was significantly upregulated...
Abstract All‐solid‐state lithium‐ion batteries (ASSLIBs) are attracting significant attention due to their high energy density, conductivity and safety. However, they expected generate substantial waste in the near future, leading resource depletion environmental pollution. Therefore, it is crucial achieve green, mild safe recovery of ASSLIBs. Here, we for first time use green deep eutectic solvents (DESs) effectively recover solid‐state electrolytes (SSEs) from ASSLIBs at temperature....
The apoptosis protection by plasminogen activator inhibitor -2(PAI-2) is dependent on a 33 amino acids fragment between helix C and D of PAI-2 which probably may be due to the interaction with unknown intracellular proteins. In this study we used as bait screen HeLa cells cDNA library constructed during in yeast two-hybrid system retrieved clone that encodes 241 proteasome (prosome, macropain) subunit, beta type 1(PSMbeta1) plays important roles NF-kappaB activation. GST-pulldown experiments...
It has been proposed that lncRNAs, widely transcribed from genomes, play pivotal regulatory roles in a variety of biological processes, but their function regulating spermatogenesis human males is rarely reported.QRT-PCR was adopted to detect HOTTIP expression level testicular tissues hypospermatogenesis (Hypo) patients or controls. The proliferation levels NT2 and 293T were measured via CCK-8 EdU detection. Meanwhile, luciferase reporter gene assay bioinformatics analysis carried out...
Long non-coding RNAs (lncRNAs) have been demonstrated to regulate metabolic tissue development and function, including adipogenesis, hepatic lipid metabolism, islet function energy balance. However, the role of lncRNAs in gluconeogenesis remains completely unknown. Metformin reduces glucose output mainly via inhibition gluconeogenesis. In present study, lncRNA expression profile primary mouse hepatocytes exposed cyclic adenosine monophosphate (cAMP), a gluconeogenic stimulus, with or without...
Supplementary Data from Down-regulation of ZIP4 by RNA Interference Inhibits Pancreatic Cancer Growth and Increases the Survival Nude Mice with Xenografts