A5065995878- Retinal Diseases and Treatments
- Thin-Film Transistor Technologies
- Atherosclerosis and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Adenosine and Purinergic Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Semiconductor materials and devices
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Alkaloids: synthesis and pharmacology
- Berberine and alkaloids research
- Cancer-related molecular mechanisms research
- Cardiomyopathy and Myosin Studies
- Nanowire Synthesis and Applications
- RNA modifications and cancer
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
- Microbial Inactivation Methods
- Ultrasound and Cavitation Phenomena
- Vascular Anomalies and Treatments
- Autophagy in Disease and Therapy
- Meat and Animal Product Quality
- Retinal Development and Disorders
- Nasal Surgery and Airway Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
ShanghaiTech University
2025
Shandong Provincial Hospital
2014-2024
Shandong First Medical University
2020-2024
Shandong University
2014-2023
Nanjing University of Chinese Medicine
2022-2023
Wuhan University
2022
Zhongnan Hospital of Wuhan University
2022
Zunyi Medical University
2021
Qilu Hospital of Shandong University
2014-2020
Coronary heart disease (CHD) is a cardiovascular which contributed by abnormal neovascularization. VEGFA (vascular endothelial growth factor A) and VEGFR2 receptor 2) have been revealed to be involved in the pathological angiogenesis. This study was intended confirm whether single nucleotide polymorphisms (SNPs) of were associated with CHD Chinese population, considering features living habits patients. Peripheral blood samples collected from 810 patients 805 healthy individuals. Six tag...
Background and Objective. It has been reported that sodium ferulate (SF) hematopoietic function against anemia immune regulation, inflammatory reaction inhibition, inhibition of tumor cell proliferation, cardiovascular cerebrovascular protection, other functions. Thus, this study aimed to investigate the effects SF on angiotensin II- (AngII-) induced cardiac hypertrophy in mice through MAPK/ERK JNK signaling pathways. Methods. Seventy-two male C57BL/6J were selected divided into 6 groups:...
We demonstrate the nonreciprocal transmission of magnonic frequency combs (MFCs) in a dissipative cavity-magnonic system. utilize recently emerged pump-induced magnon (PIM) mode YIG spheres to generate an MFC, as PIM exhibits excellent nonlinearity under coherent pumping. Meanwhile, cavity device is prepared critical bound states continuum (BIC), providing clear nonreciprocity. Based on different absorption efficiencies two opposite directions, we have demonstrated difference number comb...
Allergic conjunctivitis is a common ocular allergic condition. This study aimed to assess the knowledge, attitude, and practice (KAP) regarding among patients. A cross-sectional was conducted at outpatient clinic of Eye Hospital China Academy Chinese Medical Sciences from March June 2024. Patients completed an online self-designed questionnaire gather demographic data KAP scores, which were compared across demographics. Correlations scores analyzed, factors influencing practices explored...
To investigate the trend of dynamic changes and mechanisms P2X7R by which berberine (BBR) alleviates chronic retinal light injury in mice. A total 90 mice were randomly divided into three groups, a blank control group (n = 10), exposed to low-intensity blue (500 lux) for 12 hours per day duration 3 months, was referred as LD 40), another given BBR at dose 200 mg/kg via gastric gavage on top exposure group, + 40). After completed, eye tissues collected from Hematoxylin eosin (HE) staining...
MicroRNA (miR)‑142‑5p is a member of the miR‑142 family, which have been shown to be associated with tumors, stem cells and disorders immune system. However, role miR‑142‑5p in atherosclerosis has yet investigated. In present study, an atherosclerotic apolipoprotein E‑deficient (apoE‑/‑) mouse model was constructed fed high‑fat diet. The expression levels murine plaques were detected by gene microarray analysis. addition, vitro assay used determine human endothelial cells, smooth muscle...
Purpose: Atherosclerosis is the main cause of atherosclerotic cardiovascular disease (CVD).Here, we aimed to uncover role and mechanisms fat mass obesity-associated genes (FTO) in regulation vascular smooth muscle cell (VSMC) senescence plaques.Methods: ApoE -/-mice fed a high-fat diet (HFD) were used establish an animal model.Immunohistochemistry, staining hematoxylin-eosin, Oil Red O, Sirius red, Masson performed confirm FTO atherosclerosis vivo.Subsequently, expression primary VSMCs...
Adiponectin (APN) is an important anti‑atherogenic adipocytokine. The aim of the present study was to investigate role adiponectin in atherosclerotic plaque formation and clarify its mechanisms. An atherosclerosis model induced by vivo perivascular constrictive silica collar placement on left common carotid arteries male apolipoprotein E‑deficient (ApoE‑/‑) mice. All mice were fed a high‑fat diet, divided into phosphate‑buffered saline, adenovirus (Ad)‑β‑galactosidase Ad‑APN treatment...
Thin-film transistors (TFTs) with atomic layer deposition (ALD) HfZnO (HZO) as channel and Al2O3 gate insulator were successfully fabricated. Compared ZnO-TFT, the stability of HZO-TFT was obviously improved Hf doping can suppress generation oxygen related defects. The transfer characteristics TFTs at different temperatures also investigated, temperature enhancement observed for TFT doping. density states (DOS) calculated based on experimentally obtained E a, which explain experimental...
Abstract Angiotensin-converting enzyme 2 (ACE2) is considered as an endogenous negative regulator of renin–angiotensin system (RAS), exerting multiple cardiovascular protective roles. Whether mechanical stretch modulates ACE2 expression remains unknown. The present study aimed at investigating whether involved in physiological (10% elongation, 1 Hz) mediated cellular functions and the underlying mechanism. Cultured human aortic smooth muscle cells (HASMCs) were exposed to 10% for indicated...
Most of the existing point-to-mesh distance query solvers, such as Proximity Query Package (PQP), Embree and Fast Closest Point (FCPW), are based on bounding volume hierarchy (BVH). The hierarchical organizational structure enables one to eliminate vast majority triangles that do not help find closest point. In this paper, we develop a totally different algorithmic paradigm, named P2M , speed up queries. Our original intention is precompute KD tree (KDT) mesh vertices approximately encode...
Objective— Phospholipid transfer protein (PLTP) accelerates the development of atherosclerosis in mouse models. We examined role PLTP atherosclerotic plaque stability. Approach and Results— prepared apolipoprotein E double-knockout (PLTP −/− ApoE ) mice. deficiency significantly decreased lesion size reduced monocyte/macrophage infiltration, as well macrophage apoptosis areas. Moreover, it increased fibrous content plaques, which suggests that may affect Importantly, overexpression mediated...
Objectives We recently found low level of tumor suppressor programmed cell death 4 (PDCD4) associated with reduced atherosclerotic plaque area (unpublished). investigated whether atheroprotective unidirectional pulsatile shear stress affects the expression PDCD4 in endothelial cells. Methods and Results En face co-immunostaining mouse aortic arch revealed a cells undergoing stress. Application to human umbilical vein (HUVECs) decreased protein but not mRNA level. Immunoprecipitation that...