A5100348197- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Coronary Interventions and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Lipid metabolism and disorders
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Acute Ischemic Stroke Management
- Congenital Heart Disease Studies
- Autophagy in Disease and Therapy
- Venous Thromboembolism Diagnosis and Management
- Acupuncture Treatment Research Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Structural Anomalies and Repair
- Renin-Angiotensin System Studies
- Healthcare and Venom Research
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
Beijing Anzhen Hospital
2016-2025
Capital Medical University
2016-2025
First Affiliated Hospital Zhejiang University
2025
Nanjing Maternity and Child Health Care Hospital
2025
Nanjing Medical University
2025
Huashan Hospital
2025
Fudan University
2025
State Key Laboratory of Medical Neurobiology
2025
Changchun University of Chinese Medicine
2024
Capital University
2024
Background: Cow’s milk protein allergy (CMPA) is associated with activation of proinflammatory signaling pathways and overexpression inflammatory mediators. Long noncoding RNA (LncRNA) HOX transcript antisense intergenic (HOTAIR) a LncRNA, which involved in the occurrence development many biological processes diseases. HOTAIR can prevent necrotizing enterocolitis. This study aims to explore effect on NCM‐460 cells its mechanism action HOTAIR. Methods: were induced by cow’s establish vitro...
:BackgroundAtrial fibrosis mediates the development and maintenance of atrial fibrillation (AF). Glutathione peroxidase 4 (GPX4) is a ferroptosis biomarker. Little known about in AF, or relationship between GPX4 fibrosis.ObjectiveThis study aimed to evaluate predictive value for AF recurrence after ablation ferroptosis.MethodsThis included 249 patients with who underwent ablation. The levels serum transforming growth factor beta (TGFβ) were evaluated by enzyme-linked immunosorbent assay....
General paresis is a rare type of syphilis characterized by progressive cognitive impairment and psychiatric syndromes. It often misdiagnosed because its rarity similarity with other diseases. We aimed to comprehensively investigate the clinical, radiological, pathological, prognostic features general paresis, compare it dementias. Between August 2019 January 2024, patients were recruited from Memory Clinic Setting National Center for Neurological Disorders in China. Participants underwent...
To explore the impact of different treatment attitudes on survival status extremely preterm infants (EPIs) and evaluate mortality occurrence severe complications in actively treated infants, as well their risk factors. A retrospective analysis was conducted perinatal data EPIs born between January 1, 2016, December 31, 2023, who were admitted to neonatal intensive care unit Nanjing Women Children's Healthcare Hospital within 24 hours after birth. The focused attributable associated with...
Linear ablation in addition to pulmonary vein antrum isolation (PVAI) has failed improve the success rate for persistent atrial fibrillation (PeAF), due incomplete block of lines, especially mitral isthmus (MI).The study enrolled 191 patients (66 group 1 and 125 2). In 1, ethanol infusion into Marshall was first performed, followed by radiofrequency (RF) applications targeting bilateral PVAI bidirectional roofline, cavotricuspid isthmus, MI. 2, three linear ablations were completed using...
In advanced atherosclerosis, a large number of necrotic core increases plaque vulnerability, which leads to the occurrence acute atherothrombotic cardiovascular events. Macrophage apoptosis plays an important role in secondary necrosis. The present study aimed examine and describe effect traditional Chinese medication Tongxinluo (TXL) on macrophage atherosclerotic plaques explore its mechanism. By observing TXL ox-LDL-stimulated apoptosis, it was shown that significantly inhibited...
Anthracycline-related cardiotoxicity has a poor prognosis; therefore, early detection of any change in LV function is critical.The aim this study was to evaluate the two-dimensional speckle tracking technique for cardiac toxicity after low-dose anthracycline chemotherapy Chinese population.Forty breast cancer patients were treated by using 4-6 cycles. Patients examined echocardiography before (T0) and second (T2), fourth (T4), sixth (T6) cycle. ejection fraction (LVEF), global longitudinal...
Abstract BACKGROUND The effectiveness of renal denervation (RDN) in reducing blood pressure and systemic sympathetic activity hypertensive patients has been established. However, the underlying central mechanism remains unknown. This study aimed to investigate role RDN regulating cardiovascular function via renin–angiotensin system (RAS) pathway. METHODS Ten-week-old spontaneously rats (SHR) were subjected selective afferent (ADN) using capsaicin solution. We hypothesized that ADN would...
Data on management of maternal arrhythmia among Chinese were limited. Radiofrequency catheter ablation (RFCA) proved to be a reliable treatment choice for sustained tachyarrhythmia but it has rarely been performed during pregnancy due radiation exposure.To investigate the incidence idiopathic and feasibility RFCA in pregnant patients without fluoroscopy.From January 2015 December 2018, medical records pregnancy-related admissions Beijing Anzhen Hospital (Beijing, China) retrospectively...
No study has examined myocardial work in subjects with cancer therapy-related cardiac dysfunction (CTRCD). Myocardial work, as a new ultrasonic indicator, reflects the metabolism and oxygen consumption of left ventricle. The aim this was to test relative value indices global longitudinal strain (GLS) detecting changes function during treatment breast by two-dimensional three-dimensional echocardiography. We enrolled 79 patients undergoing different tumor regimens. Follow-up observation...
Catheter ablation of perimitral atrial tachycardia (PMAT) is challenging. Epicardial conduction the Marshall bundle (MB) across mitral isthmus (MI) remains an important cause recurrent tachycardia. The role ethanol infusion into vein (EI-VOM) for PMAT has not been fully elucidated.The study enrolled 28 consecutive patients with after fibrillation (AF) ablation. Conventional (group 1, n = 15) and MB-related 2, 13) were diagnosed by detailed activation mapping entrainment mapping. VOM...
Abstract Angiotensin-converting enzyme 2 (ACE2) is considered as an endogenous negative regulator of renin–angiotensin system (RAS), exerting multiple cardiovascular protective roles. Whether mechanical stretch modulates ACE2 expression remains unknown. The present study aimed at investigating whether involved in physiological (10% elongation, 1 Hz) mediated cellular functions and the underlying mechanism. Cultured human aortic smooth muscle cells (HASMCs) were exposed to 10% for indicated...
Tongxinluo (TXL), a traditional Chinese medication, plays key role in the formation and progression of plaques atherosclerosis. The foam cells by macrophages accelerates destabilisation plaques. In previous research, we had found that TXL significantly inhibits ox-LDL-induced apoptosis vitro improving dissociation Beclin-1-Bcl-2 complex. Therefore, here, explored effect on lipid metabolism mechanism involved. To evaluate atherosclerotic plaques, construct animal model with lentiviral...
Valvular calcification (VC) is an independent risk factor for cardiovascular diseases. The relationship between VC and atrial fibrillation not clear.
To investigate the feasibility and safety of wire-guided pericardial access without contrast.From January 2014 to February 2019, patients who received epicardial mapping ablation ventricular tachycardia in Beijing Anzhen Hospital were entered into current study. They divided contrast-guided group or according puncture technique used. The baseline variables, procedure parameters, complications collected compared.During study period, a consecutive 73 access. initial 32 with success achieved 30...
Bidirectional and durable block of mitral isthmus (MI) is essential for catheter ablation persistent atrial fibrillation (PeAF) perimitral flutter (PMF), but it remains a challenge. The aim this study was to create simple anatomical strategy with minimal fluoroscopy that would yield high success rate MI block.Patients PeAF or PMF were included. Mitral ablated in stepwise strategy. In Step 1, endocardial linear performed; 2, targeted the posterolateral portion left atrium along line; 3,...
There are limited data on long-term (> 5 years) outcomes of drug-eluting stent (DES) implantation compared with coronary artery bypass grafting (CABG) for ostial/midshaft left main (LMCA) lesions.Of the 259 consecutive patients in Beijing Anzhen Hospital LMCA lesions, 149 were treated percutaneous intervention (PCI) DES and 110 CABG. The endpoints study death, repeat revascularization, myocardial infarction (MI), stroke, composite cardiac major adverse cerebrovascular events (MACCE, MI,...