A5082477851- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Syncope and Autonomic Disorders
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Acute Myocardial Infarction Research
- Cardiac tumors and thrombi
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Cardiovascular Effects of Exercise
- Lipoproteins and Cardiovascular Health
- Cardiomyopathy and Myosin Studies
- Gout, Hyperuricemia, Uric Acid
- Cardiovascular and Diving-Related Complications
- Chemotherapy-induced cardiotoxicity and mitigation
- Climate Change and Health Impacts
- Heart Failure Treatment and Management
Capital Medical University
2015-2024
Beijing Anzhen Hospital
2015-2024
National Clinical Research Center for Digestive Diseases
2020-2024
Beijing Advanced Sciences and Innovation Center
2020-2023
National Clinical Research
2016-2023
Peking University
2011-2016
Birmingham City Hospital
2016
University of Birmingham
2016
Beijing Institute of Technology
2013
National Natural Science Foundation of China
2013
AimsThis prospective clinical trial was designed to evaluate the efficacy of an ablation strategy, namely ‘2C3L’, in treatment persistent atrial fibrillation (AF); and compare its with that ‘stepwise’ approach, which has been acknowledged as a promising technique for AF.
Reported rates of oral anticoagulation (OAC) use have been low among Chinese patients with atrial fibrillation (AF). With improved awareness, changing guidelines, this situation may be over time. We aimed to explore the current status and time trends OAC in Beijing.We used data set from Atrial Fibrillation Registry (CAFR), a prospective, multicenter, hospital-based registry study involving 20 tertiary 12 nontertiary hospitals Beijing. A total 11 496 AF were enrolled 2011 2014.Seven thousand...
Background Symptomatic prolonged sinus pauses on termination of atrial fibrillation (AF) are an accepted indication for pacemaker implantation. We evaluated the outcome AF ablation in patients with paroxysmal AF‐related tachycardia‐bradycardia syndrome and compared efficacy catheter permanent pacing plus antiarrhythmic drugs (AADs). Methods Results Patients symptomatic were retrospectively analyzed. Forty‐three consecutive who underwent (ABL group) to 57 AADs (PM group). All 43 ABL group...
Robust data on the contemporary management of atrial fibrillation (AF) patients in China are limited. Importantly current practice AF has changing dramatically recent years. Data from a large registry study will enable us to evaluate uptake and outcomes with different therapies Chinese population.The Atrial Fibrillation Registry (CAFR) aims enroll 20,000 consecutive 32 tertiary non-tertiary hospitals Beijing, China, follow up these every 6 months until 2020. Key collected includes basic...
Abstract Aims We aimed to investigate the safety of discontinuing oral anticoagulation (OAC) therapy after apparently successful atrial fibrillation (AF) ablation, using data from Chinese Atrial Fibrillation Registry study. Methods and results identified 4512 consecutive patients who underwent AF ablation between August 2011 December 2017. Of them, 3149 discontinued OAC 3 months post-ablation (Off-OAC group) 1363 continued beyond this period (On-OAC group). Regular follow-up examinations...
The potential benefits or harms of intensive systolic blood pressure (BP) control on cognitive function and cerebral flow in individuals with low diastolic (DBP) remain unclear.We conducted a post hoc analysis the SPRINT MIND (Systolic Blood Pressure Intervention Trial Memory Cognition Decreased Hypertension) that randomly assigned hypertensive participants to an (<120 mm Hg; n=4278) standard (<140 n=4385) target. We evaluated effects BP intervention outcomes across baseline DBP...
Background The knowledge gap regarding whether the correlation between atrial fibrillation (AF) and dementia in observational studies is causation or driven by other shared risk factors remains substantially unfilled. Methods Results We performed a comprehensive 2-sample Mendelian randomization study to evaluate causal effect of AF on overall its subtypes, including vascular dementia, Alzheimer Lewy body frontotemporal dementia. primary results inverse variance-weighted analyses were further...
The association between sodium-glucose cotransporter 2 inhibitors (SGLT2i) and atrial fibrillation (AF) recurrence after catheter ablation among patients with diabetes AF remains unclear.
Introduction: Circumferential pulmonary vein ablation (CPVA) with the endpoint of (PV) isolation has been developed as an effective therapy for atrial fibrillation (AF). This can be achieved either by closing gaps along circular lines or segmental PV inside after creation initial CPVA lesions. We investigated whether clinical outcome depends on approach used during first‐time procedure. Methods and Results: One hundred consecutive patients (69 male; age, 56.7 ± 11.6 years) who underwent...
This study sought to explore the relationship between plasma galectin-3 (Gal-3) and persistent atrial fibrillation (PsAF), investigate whether Gal-3 predicts clinical outcomes in patients with PsAF undergoing catheter ablation. Fifty consecutive without coexisting structural heart disease first-time ablation 46 healthy controls were included. Blood samples collected on admission for analysis of Gal-3. Pre-ablation laboratory data also recorded. Persistent fibrillations followed after AF...
The prognostic value of systolic blood pressure (SBP) time in target range (TTR) on cognitive outcomes among adults with hypertension remains unclear.We performed secondary analysis SPRINT MIND (Systolic Blood Pressure Intervention Trial Memory and Cognition Decreased Hypertension), which compared intensive (<120 mm Hg) versus standard (<140 SBP intervention hypertensive individuals. TTR was calculated from baseline to month 3 using 110 130 Hg 120 140 as for the groups, respectively....
Abstract Background In the USA, prolonged effective survival of cancer population has brought significant attention to rising risk cardiometabolic morbidity and mortality in this population. This heightened underscores urgent need for research into pharmacological interventions survivors. Notably, metformin, a well-known metabolic regulator with pleiotropic effects, shown protective effects against disorders diabetic individuals. Despite these promising indications, evidence supporting its...
Importance Success rates of pulmonary vein isolation (PVI) are modest for persistent atrial fibrillation (AF). Additional linear ablation beyond PVI has not been proved superior to alone in randomized trials. Ethanol infusion the Marshall (EIVOM) facilitates at mitral isthmus and may lead improved effectiveness a strategy. Objective To determine whether with radiofrequency energy combined EIVOM added improves sinus rhythm maintenance compared patients AF. Design, Setting, Participants The...
AimsThe aim of this study was to identify the impact obstructive sleep apnoea (OSA) on recurrence after catheter ablation paroxysmal atrial fibrillation (AF).
Background— Despite its therapeutic efficacy, warfarin is extremely underused in Chinese patients with nonvalvular atrial fibrillation (AF). Whether the nonpersistence of treatment contributes to underuse not known. The aims this study were determine rates newly started AF and identify factors associated discontinuation treatment. Methods Results— We identified 1461 enrolled Atrial Fibrillation Registry (CAFR) who on therapy period between August 1, 2011, June 30, 2014. During a follow-up...
Linear ablation in addition to pulmonary vein antrum isolation (PVAI) has failed improve the success rate for persistent atrial fibrillation (PeAF), due incomplete block of lines, especially mitral isthmus (MI).The study enrolled 191 patients (66 group 1 and 125 2). In 1, ethanol infusion into Marshall was first performed, followed by radiofrequency (RF) applications targeting bilateral PVAI bidirectional roofline, cavotricuspid isthmus, MI. 2, three linear ablations were completed using...
Systolic blood pressure (SBP) time in target range (TTR) indicates the mean value, exposure time, and variability over time. The prognostic value of SBP TTR for incident atrial fibrillation (AF) patients with hypertension is unclear.
To assess the association and predictive value of plasma homocysteine (Hcy) levels with LA/LAA thrombus in non-valvular Atrial fibrillation (AF) patients low CHA2DS2-VASc score.Eight hundred eighty-eight consecutive AF score 0 1 were enrolled. All routinely underwent transthoracic echocardiography transoesophageal echocardiography. A total thirty-two had thrombus. Compared without thrombus, Hcy significantly higher (16.5 ± 4.8 mmol/L vs. 13.4 4.1 mmol/L, P = 0.009). In multivariate analysis,...
BACKGROUND Dyslipidemia is the most frequent comorbidity in patients with cardiovascular disease. However, studies examining relationship between blood lipid profiles and AF have produced inconsistent results. MATERIAL AND METHODS A total of 651 were enrolled into 3 groups: Healthy controls (n=64), Paroxysmal (PAF; n=270), Continuous (CAF; n=317). All underwent routine baseline 12-lead electrocardiography (ECG) 24-h dynamic ECG along testing, which included following: complete metabolic...