Lianghua Chen

ORCID: 0000-0002-8459-631X
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About
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Research Areas
  • Cardiac Arrhythmias and Treatments
  • Atrial Fibrillation Management and Outcomes
  • Blood Pressure and Hypertension Studies
  • Cardiac electrophysiology and arrhythmias
  • Renin-Angiotensin System Studies
  • Antioxidant Activity and Oxidative Stress
  • Cardiac pacing and defibrillation studies
  • Hormonal Regulation and Hypertension
  • MicroRNA in disease regulation
  • Sodium Intake and Health
  • Knee injuries and reconstruction techniques
  • Lipoproteins and Cardiovascular Health
  • Sports injuries and prevention
  • Laser Design and Applications
  • RNA regulation and disease
  • Ultrasound and Hyperthermia Applications
  • Phytochemistry and Bioactivity Studies
  • Natural product bioactivities and synthesis
  • Heat shock proteins research
  • Cardiac Ischemia and Reperfusion
  • Lower Extremity Biomechanics and Pathologies
  • Galectins and Cancer Biology
  • Cancer, Lipids, and Metabolism
  • Cell death mechanisms and regulation
  • Peroxisome Proliferator-Activated Receptors

Shandong Provincial Hospital
2010-2024

Shandong First Medical University
2019-2024

Fujian University of Traditional Chinese Medicine
2021

Shandong University
2010-2020

Third Affiliated Hospital of Southern Medical University
2016-2019

Zhuhai People's Hospital
2017

Jinan University
2017

Fujian Institute of Subtropical Botany
2012

Importance Success rates of pulmonary vein isolation (PVI) are modest for persistent atrial fibrillation (AF). Additional linear ablation beyond PVI has not been proved superior to alone in randomized trials. Ethanol infusion the Marshall (EIVOM) facilitates at mitral isthmus and may lead improved effectiveness a strategy. Objective To determine whether with radiofrequency energy combined EIVOM added improves sinus rhythm maintenance compared patients AF. Design, Setting, Participants The...

10.1001/jama.2024.24438 article EN JAMA 2024-11-18

Abstract Myocardial ischemia‐reperfusion (I/R) injury is thought to have its detrimental role in coronary heart disease (CHD), which considered as the foremost cause of death all over world. However, molecular mechanism progression myocardial I/R still unclear. The goal this study was investigate expression and function microRNA‐140 (miR‐140) process injury. miR‐140 level analyzed myocardium with control using quantitative real‐time polymerase chain reaction. Then relation between YES...

10.1002/jcb.27663 article EN Journal of Cellular Biochemistry 2018-09-27

10.1016/j.bbrc.2018.03.208 article EN Biochemical and Biophysical Research Communications 2018-06-15

Effect of suspension training on neuromuscular function, postural control, and knee kinematics in anterior cruciate ligament reconstruction patients

10.12998/wjcc.v9.i10.2247 article EN World Journal of Clinical Cases 2021-03-30

Galectin-3 is a member of the β-galactoside-binding lectin family taking part in regulation inflammation, angiogenesis, and fibrosis. This study was designed to improved effect galectin-3 inhibition on diabetic cardiomyopathy (DCM). Sprague–Dawley rats were randomized into control, DCM, DCM + modified citrus pectin (MCP) (a galectin–3 pharmacological inhibitor) groups. After 8 weeks, streptozotocin-induced led high blood glucose level, oxidative stress, cardiac injury, dysfunction...

10.1139/cjpp-2019-0708 article EN Canadian Journal of Physiology and Pharmacology 2020-04-20

This study was conducted to explore whether the renin C-5312T, angiotensin II type 1 receptor A1166C, and angiotensin-converting enzyme I/D polymorphisms were associated with ambulatory blood pressure (BP) central hemodynamics in an untreated hypertensive population. A total of 471 participants no previous treatment for raised BP eligible study. Ambulatory measured. DD carriers had highest daytime systolic/diastolic BP, nighttime systolic 24-hour diastolic values, whereas higher augmentation...

10.1111/jch.13061 article EN Journal of Clinical Hypertension 2017-08-20

The main objective of this study was to determine baseline salt intake levels in a sample the adult population Shandong province and establish relationship between urinary sodium excretion blood pressure. A total 512 participants were recruited, all provided complete 24-hour urine collections. Physical assessment socioeconomic status collected at same time. mean subjects 228.0 ± 127.5 mmol/24 hours. Estimated higher obese (17.6 8.8 g/d) compared with overweight (15.6 8.0 those normal BMI...

10.1111/jch.13644 article EN cc-by-nc Journal of Clinical Hypertension 2019-07-26

Transcatheter radiofrequency ablation has been widely introduced for the treatment of tachyarrhythmias. The demand catheter continues to grow rapidly as level recommendation ablation. Traditional is performed under guidance X-rays. X-rays can help display heart contour and position, but radiobiological effects caused by ionizing radiation occupational injuries worn medical staff wearing heavy protective equipment cannot be ignored. Three-dimensional mapping system intracardiac...

10.1111/pace.14782 article EN cc-by-nc Pacing and Clinical Electrophysiology 2023-08-12

Cluster of differentiation 47 (CD47) is upregulated in mouse models doxorubicin (Dox)-induced dilated cardiomyopathy (DCM). To explore the role CD47 development DCM, present study, signaling was blocked by an anti-CD47 neutralizing antibody (aCD47) mice with Dox-induced DCM. Intraperitoneal (i.p.) administration 10 mg/kg Dox once a week significantly induced DCM after 4 weeks, which accompanied upregulation expression heart tissues. However, co-administration 7 aCD47 reduced severity lower...

10.3892/etm.2022.11277 article EN Experimental and Therapeutic Medicine 2022-03-24

Abstract Recently, we have identified that Corilagin is a major anti-tumor active component extracted from well-known hepatoprotective and antiviral medicinal herb, Phyllanthus niruri L. distinctly inhibited the growth of ovarian cancer cell lines SKOv3ip, Hey HO-8910PM, with IC50s less than 20µg/ml, while displayed low toxicity against normal surface epithelium (OSE), around 100µg/ml. induced cycle arrest at G2 stage enhanced apoptosis in cells. To explore its activity vivo, was delivered...

10.1158/1538-7445.am2012-1931 article EN Cancer Research 2012-04-01
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