A5086682354- Nuts composition and effects
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Horticultural and Viticultural Research
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Plant Pathogens and Fungal Diseases
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Plant and Fungal Interactions Research
- Plant biochemistry and biosynthesis
- Cancer Immunotherapy and Biomarkers
- Plant Molecular Biology Research
- Epigenetics and DNA Methylation
- interferon and immune responses
- Plant and animal studies
- Plant Reproductive Biology
- Mycorrhizal Fungi and Plant Interactions
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Immune cells in cancer
- Plant Stress Responses and Tolerance
- RNA Interference and Gene Delivery
- Coal Properties and Utilization
- Plant Ecology and Taxonomy Studies
University of Electronic Science and Technology of China
2025
Southwest Hospital
2012-2024
Army Medical University
2012-2024
Shandong First Medical University
2014-2024
Shandong Tumor Hospital
2016-2024
Chinese Academy of Forestry
2013-2024
Experimental Center of Forestry in North China
2019-2024
Case Western Reserve University
2024
State Key Laboratory of Plateau Ecology and Agriculture
2024
Hebei University
2024
Hepatocellular carcinoma (HCC) exhibits cellular heterogeneity and embryonic stem-cell-related genes are preferentially overexpressed in a fraction of cancer cells poorly differentiated tumors. However, it is not known whether or how these contribute to tumor initiation progression. Here, our data showed that increased expression pluripotency transcription factor Nanog correlates with worse clinical outcome HCC. Using the promoter as reporter system, we could successfully isolate small...
cGAS-STING signaling plays a critical role in radiotherapy (RT)-mediated immunomodulation. However, RT alone is insufficient to sustain STING activation tumors under safe X-ray dose. Here, we propose radiosensitization cooperated with cGAS stimulation strategy by engineering core–shell structured nanosized radiosensitizer-based agonist, which constituted the hafnium oxide (HfO2) core and manganese (MnO2) shell. HfO2-mediated enhances immunogenic cell death afford tumor associated antigens...
Chemotherapy represents an important treatment option for colorectal cancer (CRC), but only half of the patients benefit from these regimens. We explored potential predicting value and mechanism PIK3CA mutation in CRC chemotherapy. specimens 440 were retrospectively collected examined with a fluorescence PCR-based method. The correlation first-line chemotherapy response was evaluated according to follow-up medical records. underlying resistance assessed tumors primary cells. frequency gene...
Corylus L. is an economically and phylogenetically important genus in the family Betulaceae. Taxonomic phylogenetic relationships of species have long been controversial for lack effective molecular markers. In this study, complete chloroplast (cp) genomes six were assembled characterized using next-generation sequencing. We compared genome features, repeat sequences, sequence divergence, constructed species. The results indicated that cp typical standard double-stranded DNA molecule,...
Plastic phenotype convention between glioma stem cells (GSCs) and non-stem tumor (NSTCs) significantly fuels glioblastoma heterogeneity that causes therapeutic failure. Recent progressions indicate glucose metabolic reprogramming could drive cell fates. However, the pattern of GSCs NSTCs its association with phenotypes remain largely unknown. Here we found were more glycolytic than NSTCs, voltage-dependent anion channel 2 (VDAC2), a mitochondrial membrane protein, was critical for switching...
In the world, hepatocellular carcinoma (HCC) is one of most common and lethal cancers. Currently, standard therapy for unresectable HCC a local–regional with transarterial chemoembolisation (TACE). this study, we sought to assess whether plasma circulating microRNAs (miRNAs) can be used predict prognosis patients receiving TACE treatment. Firstly, systematically examined therapeutic effectiveness-related miRNAs through miRNA Profiling Chips. As result, identified 19 significantly...
Radiotherapy is one of the standard therapeutic regimens for medulloblastoma (MB). Tumor cells utilize DNA damage repair (DDR) mechanisms to survive and develop resistance during radiotherapy. It has been found that targeting DDR sensitizes tumor radiotherapy in several types cancer, but whether how pathways are involved MB response remain be determined. Single-cell RNA sequencing was carried out on 38 tissues, followed by expression enrichment assays. Fanconi anemia group D2 gene (FANCD2)...
Abstract Background Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors play a pivotal role in treating various tumors; however, the clinical characteristics molecular mechanisms of their associated heart failure (HF) remain incompletely understood. Methods We investigated epidemiological or VEGFR [VEGF(R)i]-related (VirHF) using global pharmacovigilance database Vigibase. The phenotypic features VirHF were characterized VEGF(R)i-treated mouse models through...
Corylus mandshurica, also known as pilose hazelnut, is an economically and ecologically important species in China. In this study, ten polymorphic simple sequence repeat (SSR) markers were applied to evaluate the genetic diversity population structure of 348 C. mandshurica individuals among 12 populations The SSR expressed a relatively high level (Na = 15.3, Ne 5.6604, I 1.8853, Ho 0.6668, He 0.7777). According coefficient differentiation (Fst 0.1215), variation within (87.85%) remarkably...
Epidermal growth factor receptor (EGFR) is over-expressed in about 50% of Triple negative breast cancers (TNBCs), but EGFR inhibitors have not been effective treating TNBC patients. Increasing evidence supports that autophagy was related to drug resistance at present. However, the role and mechanism treatment remain unknown. In current study, we investigated effect inhibitor gefitinib (Ge) cells vitro nude mice vivo. Our study demonstrated inhibition by 3-Methyladenine or bafilomycin A1...
Previous phylogenetic conclusions on the family Betulaceae were based either morphological characters or traditional single loci, which may indicate some limitations. The chloroplast genome contains rich polymorphism information, is very suitable for studies. Thus, we sequenced sequences of three species and performed multiple analyses to investigate variation, resolve relationships, clarify divergence history.Chloroplast genomes using high-throughput sequencing. A comparative genomic...
Abstract Background The existing cell surface markers used for sorting glioma stem cells (GSCs) have obvious limitations, such as vulnerability to the enzymatic digestion and time-consuming labeling procedure. Reduced nicotinamide adenine dinucleotide (NADH) a cellular metabolite with property of autofluorescence has potential be new biomarker GSCs. Methods A method GSCs was established according properties NADH. Then, NADH high low subpopulations were sorted. stem-like evaluated by qRT-PCR,...
Plant growth-promoting rhizobacteria (PGPRs) are able to activate induced systemic resistance (ISR) of the plants against phytopathogens. However, whether and how ISR can be activated by PGPRs in Rosa genus is unclear. The effects PGPR Bacillus velezensis CLA178 pathogen Agrobacterium tumefaciens C58 on growth, plant defense-related genes, hormones, reactive oxygen species (ROS) rose were compared. Pretreatment with significantly reduced crown gall tumor biomass relieved negative biomass,...
Diabetes-associated cognitive impairment (DACI) is a common complication of diabetes mellitus (DM) that affects the central nervous system. Cognitive impairment, such as learning and memory even dementia, main clinical manifestation DACI. Unfortunately, there no effective means by which to delay symptoms DM. Evidence has shown strawberry leaf extract could alleviate decline, suppress oxidative stress, reduce inflammatory responses in rats. In present study, we evaluated effect on function...
Long non-coding RNA (lncRNA) myocardial infarction-associated transcript (MIAT) has been widely-demonstrated to function as diagnostic markers for acute infarction (MI). This study was designed explore the modulatory role of MIAT and its underlying molecular mechanism in MI. Firstly, MI mouse model developed via ligation descending branch left coronary artery, cell established through exposure hypoxic conditions. Online prediction indicated that could bind microRNA-10a-5p (miR-10a-5p), while...
A correct classification of fungi, including yeasts, is prime importance to understand fungal biodiversity and communicate about this diversity. Fungal genera are mainly defined based on phenotypic characteristics the results single or multigene-based phylogenetic analyses. However, because yeasts often have less characters, their experienced a strong move towards DNA-based data, from short ribosomal sequences multigene phylogenies more recently phylogenomics. Here, we explore usefulness...
Diabetes has been identified to be a risk factor for Alzheimer's disease (AD). Vildagliptin, novel oral hypoglycemic agent, demonstrated exert protective effects on the pancreas and cardiovascular system. The present study examined potential of vildagliptin neurons in an AD rat model. Treatment with improved memory deficits decreased neuronal apoptosis hippocampus. expression levels B cell lymphoma 2 (Bcl‑2) were increased, caspase‑3, Bcl‑2 associated X protein AD‑associated proteins...
Silicosis is an occupational disease characterized by extensive pulmonary fibrosis, and the underlying pathological process remains uncertain. Herein, we explored molecular mechanism which microRNA-205-5p (miR-205-5p) affects autophagy of alveolar macrophages (AMs) fibrosis in mice with silicosis through E2F transcription factor 1 (E2F1)/S-phase kinase-associated protein 2 (SKP2)/Beclin1 axis. Alveolar (MH-S cells) were exposed to crystalline silica (CS) develop vitro model, treated CS...