A5060051790- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Immune cells in cancer
- Ga2O3 and related materials
- MXene and MAX Phase Materials
- Machine Learning in Materials Science
- Cancer Immunotherapy and Biomarkers
- Metal-Organic Frameworks: Synthesis and Applications
- Autophagy in Disease and Therapy
- Single-cell and spatial transcriptomics
- Nanoparticle-Based Drug Delivery
- Nanocluster Synthesis and Applications
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Advanced Photocatalysis Techniques
- interferon and immune responses
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Advanced Radiotherapy Techniques
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Enzyme function and inhibition
- Adenosine and Purinergic Signaling
- CAR-T cell therapy research
- Inflammatory Biomarkers in Disease Prognosis
Army Medical University
2020-2025
Southwest Hospital
2020-2024
Institute of High Energy Physics
2023
Chinese Academy of Sciences
2023
Ministry of Education of the People's Republic of China
2020
Radiotherapy (RT) is one of the important clinical treatments for local control triple-negative breast cancer (TNBC), but radioresistance still exists. Ferroptosis has been recognized as a natural barrier progression and represents significant role RT-mediated anticancer effects, while simultaneous activation ferroptosis defensive system during RT limits synergistic effect between ferroptosis. Herein, we engineered tumor microenvironment (TME) degradable nanohybrid with dual...
Abstract Only a small proportion of patients with triple-negative breast cancer benefit from immune checkpoint inhibitor (ICI) targeting PD-1/PD-L1 signaling in combination chemotherapy. Here, we discovered that therapeutic response to ICI plus paclitaxel was associated subcellular redistribution PD-L1. In our immunotherapy cohort nab-paclitaxel, tumor samples responders showed significant distribution PD-L1 at mitochondria, while non-responders increased accumulation on cell membrane...
Monocyte-derived tumor-associated macrophages (Mo-TAMs) intensively infiltrate diffuse gliomas with remarkable heterogeneity. Using single-cell transcriptomics, we chart a spatially resolved transcriptional landscape of Mo-TAMs across 51 patients isocitrate dehydrogenase (IDH)-wild-type glioblastomas or IDH-mutant gliomas. We characterize Mo-TAM subset that is localized to the peri-necrotic niche and skewed by hypoxic cues acquire hypoxia response signature. Hypoxia-TAM destabilizes...
cGAS-STING signaling plays a critical role in radiotherapy (RT)-mediated immunomodulation. However, RT alone is insufficient to sustain STING activation tumors under safe X-ray dose. Here, we propose radiosensitization cooperated with cGAS stimulation strategy by engineering core–shell structured nanosized radiosensitizer-based agonist, which constituted the hafnium oxide (HfO2) core and manganese (MnO2) shell. HfO2-mediated enhances immunogenic cell death afford tumor associated antigens...
Abstract With the successful marriage between nanotechnology and oncology, various high‐ Z element containing nanoparticles (NPs) are approved as radiosensitizers to overcome radiation resistance for enhanced radiotherapy (RT). Unfortunately, NPs themselves lack specificity tumors. Due inherent tropism nature of malignant cells, mesenchymal stem cells (MSCs) emerge cell‐mediated delivery vehicles functional improve their therapeutic index. Herein, radiosensitive bismuth selenide (Bi 2 Se 3 )...
Abstract Nanomedicine‐based synergy of chemodynamic therapy (CDT) and radiotherapy (RT) modulated by tumor microenvironment enables rapid ablation, which holds great hope for the refractory recurrent cancers, such as triple negative breast cancer (TNBC). The clinical translation hafnium oxide (HfO 2 ), commercially named NBTXR3, has aroused new research focus on single‐component inorganic nanomedicines candidates. Herein, MnWO 4 is first reported a kind Fenton‐like agent yet radiosensitizer...
With the recent success of immune checkpoint blockade (ICB) in cancer immunotherapy, there has been renewed interest evaluating combination ICB inhibitors with radiotherapy (RT) clinical trials view localized RT-initiated vaccination effect, which can be augmented further by systemic immune-stimulating agents. Unfortunately, traditional RT/ICB accompanies severe toxicity from high-dose ionizing irradiation and low response rate RT-aggravated immunosuppression, among M2-type tumor-associated...
Catalytic Nanoradiosensitizers In article number 2306328, Jiangfeng Du, Xiao Zhang, Gan Tian, and co-workers engineer single-component manganese tungstate (MnWO4) as a new kind of catalytic nanoradiosensitizer, which shows augmented Fenton-like effect under X-ray stimulation enables the synergy chemodynamic therapy radiotherapy for efficient treatment triple negative breast cancer, expanding nanomedicine library potential clinical candidates.
Hafnium-Based Nanomaterials The clinical translation of hafnium oxide for cancer radiotherapy has aroused extensive interest on Hf-based nanomaterials biomedical application. In article number 2300341, Gan Tian, Wenyan Yin, and co-workers comprehensively summarize the recent advances in synthesis, computed tomography (CT)-involved diagnosis radiotherapy-related synergistic therapy nanomaterials. More efforts will be invested these promising nanomedicines as candidates future.