A5100437095- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Connective tissue disorders research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Prostate Cancer Diagnosis and Treatment
- Heat shock proteins research
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Nanoparticle-Based Drug Delivery
- Redox biology and oxidative stress
- Plant Stress Responses and Tolerance
- NF-κB Signaling Pathways
- Urinary Bladder and Prostate Research
- Urological Disorders and Treatments
- Ubiquitin and proteasome pathways
- Plant Genetic and Mutation Studies
- Glutathione Transferases and Polymorphisms
- Advanced Nanomaterials in Catalysis
- Dementia and Cognitive Impairment Research
- ATP Synthase and ATPases Research
Nantong University
2024
Changzhi Medical College
2024
Army Medical University
2009-2022
Army Medical College
2022
Previous studies on esophageal squamous cell carcinoma (ESCC) indicated that it contains much dysregulation of microRNAs (miRNAs). DNA hypermethylation in the miRNA 5' regulatory region is a mechanism can account for downregulation tumors (Esteller, N Engl J Med 2008;358:1148-59). Among those dysregulated miRNAs, miR-203, miR-34b/c, miR-424 and miR-129-2 are embedded CpG islands, as promoter miR-34a. We investigated their methylation status ESCC by bisulfite sequencing PCR (BSP) specific...
Abstract Background miR-34a functions as an important tumor suppressor during the process of carcinogenesis. However, mechanism dysregulation in human malignancies has not been well elucidated. Our study aimed to further investigate regulation miR-34a. Results We found that overexpression NF-kappa B p65 subunit could increase levels EC109, esophageal squamous cancer cell line, while ectopic expression DN IkappaB leaded a significant reduction expression. Bioinformatics analysis suggested...
MicroRNAs (miRNAs) are small, non-protein-coding RNAs that function as tumour suppressors or oncogenes. A single nucleotide change in the sequence of pre-miRNA can affect miRNA expression, so single-nucleotide polymorphisms (SNPs) may be biomarkers for biomedical applications. In this study, we performed a genetic association study between SNP (rs11614913) pre-miRNA-196a and esophageal squamous cell carcinoma (ESCC) susceptibility case–control study. We found homozygote CC increased risk...
Recent studies have highlighted the role of miR-5195-3p in suppressing cell growth various cancers. However, specific functional impact colorectal cancer (CRC) remain to be fully clarified. The importance CRC was evaluated, aiming uncover its underlying molecular mechanism and identify it as a potential therapeutic target for CRC.
Objective To confirm clinical diagnosis of Marfan syndrome via mutational analysis.To compare the difference between these Chinese patients with reported previously.To characterize features in two families. MethodsFamily investigation and pedigree analysis were performed families, mutation FBN1 gene was detected by combining polymerase chain reaction ( PCR ) followed direct DNA sequencing. ResultsThese families characterized as an autosomal dominant inheritance. Molecular genetic on all...
Abstract Lactate arouses an increasing concern in recent studies of Alzheimer’s disease (AD). At late stage AD, amyloid beta (Aβ) directly promotes lactate level, continuously activating microglial inflammation and aggravating neuronal damage. However, whether fluctuation can effect on Aβ hasn’t been recognized. Especially, it is observed a reduction the hippocampus cortex early AD mouse model. Hence, this study discusses relation between decreased production at its possibly mechanism. As...