A5103114926- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic diversity and population structure
- Circular RNAs in diseases
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Turtle Biology and Conservation
- Cell death mechanisms and regulation
- Monoclonal and Polyclonal Antibodies Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- Diatoms and Algae Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Aquaculture disease management and microbiota
- interferon and immune responses
- Plant and animal studies
- Mycobacterium research and diagnosis
Genecast (China)
2023
Dazhou Central Hospital
2021-2022
Hunan Agricultural University
2014-2021
Chongqing Vocational and Technical University of Mechatronics
2014-2021
Army Medical University
2008-2019
Southwest Hospital
2008-2019
Wuhan University
2019
Wuhan Asia Heart Hospital
2019
Previous studies on esophageal squamous cell carcinoma (ESCC) indicated that it contains much dysregulation of microRNAs (miRNAs). DNA hypermethylation in the miRNA 5' regulatory region is a mechanism can account for downregulation tumors (Esteller, N Engl J Med 2008;358:1148-59). Among those dysregulated miRNAs, miR-203, miR-34b/c, miR-424 and miR-129-2 are embedded CpG islands, as promoter miR-34a. We investigated their methylation status ESCC by bisulfite sequencing PCR (BSP) specific...
Polymorphisms in 3′ untranslated region (UTR) of cancer-related genes might affect regulation by microRNA (miRNA) and contribute to carcinogenesis. In this study, we screened several single nucleotide polymorphisms (SNPs) 3′UTR investigated their effects on the risk esophageal squamous cell carcinoma (ESCC). First, used SNaPshot assay genotype seven SNPs 537 ESCC cases 608 normal controls a Chinese Han population found that SNP rs6573 RAS-related proteins (RAP1A) was significantly associated...
Long noncoding RNAs (lncRNAs) have been shown to play various roles in tumorigenesis, among which lncRNA H19 has revealed as an ambivalent factor that acts both oncogene and a tumor suppressor carcinogenesis. However, the exact biological role of esophageal squamous cell carcinoma (ESCC) remains be determined. The aim this study was examine expression pattern ESCC evaluate its clinical significance progression ESCC. Expression analyzed 64 tissues four lines by quantitative...
MicroRNAs (miRNAs) are small, non-protein-coding RNAs that function as tumour suppressors or oncogenes. A single nucleotide change in the sequence of pre-miRNA can affect miRNA expression, so single-nucleotide polymorphisms (SNPs) may be biomarkers for biomedical applications. In this study, we performed a genetic association study between SNP (rs11614913) pre-miRNA-196a and esophageal squamous cell carcinoma (ESCC) susceptibility case–control study. We found homozygote CC increased risk...
SUMMARY OBJECTIVE: Our study aimed to investigate the diagnostic value of lncRNA H19 for coronary artery disease (CAD) and explore its possible mechanisms. Methods: A total 30 CAD patients healthy individuals, as well with different cardiovascular diseases, were included in this study. Blood was drawn from each participant prepare serum samples, expression detected using qRT-PCR. The ROC curve analysis used analyze CAD. effects patients' basic information lifestyle on analyzed. plasma level...
Background Syndactyly type 1 (SD1) is an autosomal dominant limb malformation characterized in its classical form by complete or partial webbing between the third and fourth fingers and/or second toes. Its four subtypes (a, b, c, d) are defined based on variable phenotypes, but responsible gene yet to be identified. SD1-a has been mapped chromosome 3p21.31 SD1-b 2q34–q36. SD1-c SD1-d very rare and, our knowledge, no loci have Methods Results In two Chinese families with SD1-c, linkage...
Epithelial-mesenchymal transition (EMT) is a developmental program, which associated with esophageal squamous cell carcinoma (ESCC) progression and metastasis. Recently, C/EBPβ reported to be an EMT inducer in cancer. However, the detailed molecular mechanisms remain unclear. Here we report for first time, that truncated LIP isoform was abnormally overexpressed correlated cancer metastasis clinical specimens of human ESCC. Furthermore, demonstrate mediates epithelial growth factor (EGF) -...
Survivin is an inhibitor of apoptosis protein, which selectively up-regulated in various cancers including esophageal cancer. The underlying mechanism survivin overexpression still unclear. We investigated resected tumor specimens from 100 cancer patients. Reverse transcription polymerase chain reaction was performed to evaluate gene expression. Polymerase reaction-single strand conformation polymorphism investigate mutations p53. found that the expression tumors with mutant p53 higher than...
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers in world. Epidemiological survey studies have verified that development ESCC relates to a complex interactive process between multiple genetic susceptibilities and environmental exposure. Serpins are broadly distributed family protease inhibitors been recognized as tumor suppressors cancer types. While previous reported Serpin polymorphisms associated with tumorigenesis, functional single nucleotide (SNP) these...
Decoy receptor 3 (DcR3) is a soluble without transmembrane and intracellular sequences in its peptide. It can bind to inactivate the apoptosis-inducing ligand FasL, LIGHT, TL1A. The aims of this study are genotype two polymorphisms promotor DcR3 esophageal squamous cell cancer patients controls analyze association between individual genetic variation susceptibility carcinoma (ESCC). A total 444 Chinese ESCC 468 matched cancer-free were evaluated for single nucleotide (SNPs) DCR3....
The present study aimed to elucidate the biological function of circular RNAs (circRNA) 0074027 in colorectal cancer (CRC). expression circRNA‑0074027 CRC tissues and cells was determined by reverse transcription‑quantitative PCR. <em>in vitro</em> experiments, including Cell Counting Kit‑8 (CCK‑8) assay, 5‑Ethynyl‑2'‑deoxyuridine flow cytometry Transwell were applied evaluate cell proliferation, apoptosis metastasis ability respectively following downregulation circRNA‑0074027. correlation...
Objective: Decoy receptor 3 (DcR3) is a soluble receptor, which can bind to and inactivate the apoptosis-inducing ligands. We studied possible association between DcR3 expression clinicopathologic features in patients with esophageal squamous cell carcinoma (ESCC).Methods: The mRNA of was examined by RT-PCR 109 primary ESCC patients. For 52 pairs positive tissues, protein determined immunohistochemistry.Results: There strong correlation among tumor invasion (P = 0.01) lymph node metastasis...
Abstract Background Aquatic animals show diverse body coloration, and the formation of animal colour is a complicated process. Increasing evidence has shown that microRNAs (miRNAs) play important regulatory roles in many life processes. The role miRNAs pigmentation been investigated some species. However, patterns reptile remain to be elucidated. In this study, we performed an integrated analysis miRNA mRNA expression profiles explore corresponding embryonic soft-shelled turtle Pelodiscus...
Genetic diversity is an important component of biodiversity and investigating protecting the wild genetic species has always been research topic in conservation biology. Due to habitat destruction over catching, Chinese soft-shell turtles (Pelodiscus spp.) have severely damaged, resulting being listed on IUCN Red List Threatened Species 2000. However, only few studies with contradictory results Pelodiscus reported. To investigate population structure turtles, 123 specimens were collected...
The Chinese soft-shelled turtle (Pelodiscus sinensis) is one of the most important freshwater aquaculture reptiles in East and Southeast Asia. In contrast to other strains this species, Qingxi black has skin. study, three turtles (WBF) Dongting Lake (DTF) were investigated compare analyze their differences skin color by mRNA sequencing miRNA sequencing. Total 1,772 differentially expressed mRNAs identified including 1,079 upregulated 693 downregulated WBF. Through sequencing, 1,071 miRNAs...