A5102735355- Nanoplatforms for cancer theranostics
- Head and Neck Cancer Studies
- Mine drainage and remediation techniques
- Oral Health Pathology and Treatment
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Iron oxide chemistry and applications
- Digital Mental Health Interventions
- Antibiotic Resistance in Bacteria
- Flame retardant materials and properties
- Arsenic contamination and mitigation
- Reconstructive Surgery and Microvascular Techniques
- Impact of Technology on Adolescents
- Advanced Nanomaterials in Catalysis
- Renal Transplantation Outcomes and Treatments
- Mental Health Research Topics
- Artificial Intelligence in Healthcare and Education
- COVID-19 and Mental Health
- Family Support in Illness
- Obstructive Sleep Apnea Research
- Advanced Drug Delivery Systems
- Metal Extraction and Bioleaching
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Reconstructive Facial Surgery Techniques
Hubei University of Chinese Medicine
2023-2025
South China University of Technology
2022-2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
Guangzhou Medical University
2020-2024
Southwest Hospital
2018-2024
Stomatology Hospital
2020-2024
Army Medical University
2018-2024
Sun Yat-sen University
2020-2024
Second Affiliated Hospital of Guangzhou Medical University
2020-2023
Radiotherapy (RT) is one of the important clinical treatments for local control triple-negative breast cancer (TNBC), but radioresistance still exists. Ferroptosis has been recognized as a natural barrier progression and represents significant role RT-mediated anticancer effects, while simultaneous activation ferroptosis defensive system during RT limits synergistic effect between ferroptosis. Herein, we engineered tumor microenvironment (TME) degradable nanohybrid with dual...
cGAS-STING signaling plays a critical role in radiotherapy (RT)-mediated immunomodulation. However, RT alone is insufficient to sustain STING activation tumors under safe X-ray dose. Here, we propose radiosensitization cooperated with cGAS stimulation strategy by engineering core–shell structured nanosized radiosensitizer-based agonist, which constituted the hafnium oxide (HfO2) core and manganese (MnO2) shell. HfO2-mediated enhances immunogenic cell death afford tumor associated antigens...
The synergistic combination of photothermal and RNA interference therapy demonstrates great potential for effective treatment metastatic breast cancer, but their efficacy is limited by the poor delivery efficiency to tumor. Herein, it reported that an albumin biomimetic nanocorona (DRI‐S@HSA) can accomplish high accumulation deep penetration within tumor tissues, thereby holding promise therapy. DRI‐S@HSA prepared camouflaging human serum (HSA) onto IR‐780 small interfering RNA‐loaded...
Abstract Cancer stem cells (CSCs) are proposed to account for the initiation of cancer metastasis, but their accessibility remains a great challenge. This study reports deep tumor‐penetrated biomimetic nanocages augment CSCs fractions in tumor anti‐metastasis therapy. The can load photothermal agent 1,1‐dioctadecyl‐3,3,3,3‐tetramethylindotricarbocyanine iodide (DBN) and chemotherapeutic epirubicin (EBN) eradicate photothermal‐chemotherapy breast metastasis. In metastatic 4T1‐indcued model,...
Abstract With the successful marriage between nanotechnology and oncology, various high‐ Z element containing nanoparticles (NPs) are approved as radiosensitizers to overcome radiation resistance for enhanced radiotherapy (RT). Unfortunately, NPs themselves lack specificity tumors. Due inherent tropism nature of malignant cells, mesenchymal stem cells (MSCs) emerge cell‐mediated delivery vehicles functional improve their therapeutic index. Herein, radiosensitive bismuth selenide (Bi 2 Se 3 )...
The efficient and specific drug delivery to brain tumor is a crucial challenge for successful systemic chemotherapy. To overcome these limitations, here tumor‐triggered programmed wormlike micelle reported with precise targeting deep penetration treat malignant gliomas, which composed of pH‐responsive mPEG‐ b ‐PDPA copolymer bioreducible cyclic RGD peptide targeted cytotoxic emtansine (DM1) conjugates (RGD‐DM1). RGD‐DM1 loaded nanoscaled micelles (RNW) exhibit nanometer‐sized assemblies the...
Cancer metastasis is the leading reason for high mortality of breast cancer.Herein, we report on a pH-responsive host-guest nanosystem succinobucol (PHN) with pH-stimuli controlled drug release behavior to improve therapeutic efficacy lung cancer.PHN was composed host polymer β-cyclodextrin linked multiple arms N,N-diisopropylethylenediamine (βCD-DPA), guest adamantyl end-capped methoxy poly(ethylene glycol) (mPEG-Ad), and active agent succinobucol.PHN comprises nanometer-sized homogenous...
Necroptosis is a recently discovered form of programmed cell death (PCD) having necrotic-like morphology. However, its presence and potential impact with respect to head neck squamous carcinoma (HNSCC) are still unknown. The aim this study was reveal the necroptosis status clinicopathological relevance in HNSCC establish an vitro model. We first analyzed level p-MLKL, MLKL, tumor necrosis patient tissues as well their correlation features. Results showed that approximately half can be...
With the recent success of immune checkpoint blockade (ICB) in cancer immunotherapy, there has been renewed interest evaluating combination ICB inhibitors with radiotherapy (RT) clinical trials view localized RT-initiated vaccination effect, which can be augmented further by systemic immune-stimulating agents. Unfortunately, traditional RT/ICB accompanies severe toxicity from high-dose ionizing irradiation and low response rate RT-aggravated immunosuppression, among M2-type tumor-associated...
Abstract Nanomedicine‐based synergy of chemodynamic therapy (CDT) and radiotherapy (RT) modulated by tumor microenvironment enables rapid ablation, which holds great hope for the refractory recurrent cancers, such as triple negative breast cancer (TNBC). The clinical translation hafnium oxide (HfO 2 ), commercially named NBTXR3, has aroused new research focus on single‐component inorganic nanomedicines candidates. Herein, MnWO 4 is first reported a kind Fenton‐like agent yet radiosensitizer...
Fear of cancer recurrence (FCR) is common among patients and high clinical relevance. This study explores the prevalence correlates FCR in Chinese newly diagnosed population.This a multicentre, cross-sectional that includes 996 with mixed diagnosis. All recently completed questionnaire consisting following: Progression Questionnaire-Short Form (FoP-Q-SF), General Anxiety Disorder Questionnaire (GAD-7), Patient Health (PHQ-9). Univariate analyses, multivariate logistic regression structural...
Abstract Addressing the treatment and prevention of antibacterial-resistant gram-negative bacterial infections is a priority area Antibacterial Resistance Leadership Group (ARLG). The ARLG has conducted series observational studies to define clinical molecular global epidemiology carbapenem-resistant ceftriaxone-resistant Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii, with goal optimizing design execution interventional studies. One ongoing study aims better understand...