A5027010615- Nanoplatforms for cancer theranostics
- Advancements in Solid Oxide Fuel Cells
- Luminescence Properties of Advanced Materials
- Electronic and Structural Properties of Oxides
- Electrocatalysts for Energy Conversion
- Advanced Nanomaterials in Catalysis
- Luminescence and Fluorescent Materials
- Catalytic Processes in Materials Science
- Catalysis and Oxidation Reactions
- Graphene and Nanomaterials Applications
- Magnetic and transport properties of perovskites and related materials
- Advanced biosensing and bioanalysis techniques
- Radiation Detection and Scintillator Technologies
- Quantum Dots Synthesis And Properties
- Radioactive element chemistry and processing
- Photoacoustic and Ultrasonic Imaging
- Chemical Synthesis and Characterization
- Electrochemical sensors and biosensors
- Carbon and Quantum Dots Applications
- MXene and MAX Phase Materials
- Metal-Organic Frameworks: Synthesis and Applications
- Immune cells in cancer
- Ga2O3 and related materials
- Perovskite Materials and Applications
- Inorganic Fluorides and Related Compounds
Army Medical University
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Southwest Hospital
2017-2024
Suzhou University of Science and Technology
2022-2024
Sichuan University
2009-2023
Ministry of Education of the People's Republic of China
2020-2023
University of Maryland, College Park
2023
Universidad del Noreste
2023
Xinyang Normal University
2022
State Key Laboratory of Chemical Engineering
2017-2021
We report here a simple, high-yield yet low-cost approach to design single-layer MoS2 nanosheets with controllable size via an improved oleum treatment exfoliation process. By decorating chitosan, these functionalized have been developed as chemotherapeutic drug nanocarrier for near-infrared (NIR) photothermal-triggered delivery, facilitating the combination of chemotherapy and photothermal therapy into one system cancer therapy. Loaded doxorubicin could be controllably released upon effect...
Pure dark red emission (650–670nm) of NaYF4:Yb/Er upconversion nanoparticles (UCNPs) is achieved by manganese ions (Mn2+) doping. In addition, the Mn2+- doping can also control crystalline phase and size resulting UCNPs simultaneously. Drug delivery studies suggest promise these as drug carriers for intracellular eventually a multifunctional nanoplatform simultaneous diagnosis therapy. Detailed facts importance to specialist readers are published "Supporting Information". Such documents...
Here, we present a precision cancer nanomedicine based on Bi2S3 nanorods (NRs) designed specifically for multispectral optoacoustic tomography (MSOT)/X-ray computed (CT)-guided photothermal therapy (PTT). The as-prepared NRs possess ideal effect and contrast enhancement in MSOT/CT bimodal imaging. These features make them simultaneously act as "satellite" "precision targeted weapon" the visual guide to destruction of tumors vivo, realizing effective tumor metastasis inhibition after...
Nd3+-sensitized quenching-shield sandwich-structured upconversion nanoparticles are reported, which exhibit highly efficient photoluminescence under excitation by an 800 nm continuous-wave laser. The transition-layer structure is essential to bridge energy transfer from the sensitizer activator and simultaneously block back-transfer sensitizer. These nm-excited a key step toward development of nanophosphors for biological applications.
Antimonene (AM) is a recently described two-dimensional (2D) elemental layered material. In this study, novel photonic drug-delivery platform based on 2D PEGylated AM nanosheets (NSs) developed. The platform's multiple advantages include: i) excellent photothermal properties, ii) high drug-loading capacity, iii) spatiotemporally controlled drug release triggered by near-infrared (NIR) light and moderate acidic pH, iv) superior accumulation at tumor sites, v) deep penetration both extrinsic...
We have developed a simple and efficient strategy to fabricate WS2 nanosheets with low toxicity good water solubility via liquid exfoliation method by using H2SO4 intercalation ultrasonication. The as-prepared were employed not only as an NIR absorbing agent for photothermal therapy (PTT) but also photosensitizer (PS) carrier photodynamic (PDT) due their sheet like structure that offers large surface area load PS molecules. Moreover, singlet-oxygen generation of the PSs-WS2 complex could be...
The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the therapy.Here, magnetic targeted photothermal therapy was demonstrated by integration of MoS 2 (MS) flakes and Fe 3 O 4 (IO) nanoparticles (NPs), where converted near-infrared (NIR) light into heat NPs served as target moiety directed external field tumor site.The /Fe composite (MSIOs) functionalized biocompatible polyethylene glycol (PEG) were prepared a simple two-step hydrothermal...
NaYbF 4 :Tm@NaYF :Yb/Er upconversion nanoparticles are synthesized and then integrated with light‐sensitive nitric oxide (NO) donors (Roussin's black salt) to construct a novel near‐infrared (NIR)‐triggered on‐demand NO delivery platform. This nanocompound can absorb 980 nm NIR photons, convert them into higher energy photons transfer the donors, resulting in an efficient release of NO. By manipulating output power 980‐nm light, NO‐concentration‐dependent biological effects for cancer...
Emerging two-dimensional (2D) nanomaterials, such as transition-metal dichalcogenide (TMD) nanosheets (NSs), have shown tremendous potential for use in a wide variety of fields including cancer nanomedicine. The interaction nanomaterials with biosystems is critical importance their safe and efficient application. However, cellular-level understanding the nano-bio interactions these emerging 2D (i.e., intracellular mechanisms) remains elusive. Here we chose molybdenum disulfide (MoS2) NSs...
How to optimize the enzyme-like catalytic activity of nanozymes improve their applicability has become a great challenge. Herein, we present an l-cysteine (l-Cys) coordination-driven self-assembly strategy activate polyvinylpyrrolidone (PVP)-modified Cu single-atom MoOx-Cu-Cys (denoted as MCCP SAzymes) aiming at tumor-specific therapy. The single atom content can be rationally modulated 10.10 wt %, which activates catalase (CAT)-like MoOx nanoparticles catalyze decomposition H2O2 in acidic...
Radiotherapy (RT) is one of the important clinical treatments for local control triple-negative breast cancer (TNBC), but radioresistance still exists. Ferroptosis has been recognized as a natural barrier progression and represents significant role RT-mediated anticancer effects, while simultaneous activation ferroptosis defensive system during RT limits synergistic effect between ferroptosis. Herein, we engineered tumor microenvironment (TME) degradable nanohybrid with dual...
cGAS-STING signaling plays a critical role in radiotherapy (RT)-mediated immunomodulation. However, RT alone is insufficient to sustain STING activation tumors under safe X-ray dose. Here, we propose radiosensitization cooperated with cGAS stimulation strategy by engineering core–shell structured nanosized radiosensitizer-based agonist, which constituted the hafnium oxide (HfO2) core and manganese (MnO2) shell. HfO2-mediated enhances immunogenic cell death afford tumor associated antigens...
Abstract Upconverting nanoparticles (UCNPs) have attracted considerable attention as potential photosensitizer carriers for photodynamic therapy (PDT) in deep tissues. In this work, a new and efficient NIR photosensitizing nanoplatform PDT based on red‐emitting UCNPs is designed. The red emission band matches well with the absorption bands of widely used commercially available photosensitizers (Ps), benefiting fluorescence resonance energy transfer (FRET) from to attached thus efficiently...
Rare-earth (RE)-doped gadolinium oxide (Gd2O3) hollow nanospheres have been successfully prepared on a large scale via template-directed method using hydrothermal carbon spheres as sacrificed templates. Scanning electron microscope and transmission images reveal that these hollow-structured the mesoporous shells are composed of amount uniform nanoparticles. By doping RE ions (Yb/Er) into Gd2O3 host matrix, NPs emitted bright multicolored upconversion emissions can be fine-tuned from green to...
Under 980 nm near-infrared (NIR) excitation, upconversion luminescent (UCL) emission of GdF(3):Yb,Er nanoparticles (UCNPs) synthesized by a simple and green hydrothermal process can be tuned from yellow to red varying the concentration dopant Li(+) ions. A possible mechanism for enhanced upconverted radiation is proposed. layer silica was coated onto surface GdF(3):Yb,Er,Li UCNPs improve their biocompatibility. The silica-coated show great advantages in cell labeling vivo optical imaging....
Lanthanide (Ln3+) doped Gd2O3 nanoparticles (NPs) have been prepared via a thermal treatment of gadolinium carbonate precursor, which was obtained by simple hydrothermal Gd(NO3)3 solution in the presence urea and glycerol. The size could be fine tuned from 270 to 10 nm varying amount glycerol, acted as chelating agent control nanoparticles. Calcination at 500 °C led formation uniform without any obvious morphology change. By doping lanthanide ions (Yb, Er/Tm) into host matrix, these emitted...
Lanthanide ion doped GdVO4 upconversion nanoparticles (UCNPs) have been synthesized via a simple hydrothermal process assisted with polyvinylpyrrolidone (PVP). The PVP had great effects on the morphology and luminescent intensity of final products. Multicolor emissions such as orange, yellow, green blue light can be generated by simply changing codopant compositions or concentrations in these nanoparticles. A thin layer silica was coated onto surface UCNPs to form core/shell structure order...
A β-cyclodextrin (β-CD) functionalized magnetic graphene hybrid (mGO-β-CD) has been prepared and its application as an adsorbent for the removal of organic dyes investigated. Magnetic hybrids (mGOs) were first synthesized via a chemical precipitation method, then β-CDs applied to further functionalize resultant mGO hybrid. The results demonstrate that as-prepared mGO-β-CD exhibits greatly enhanced adsorption performance in water. Acid fuchsin Rhodamine 6G, typical dye pollutants, can be...