A5074966934- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Sulfur Compounds in Biology
- Inflammatory mediators and NSAID effects
- Phytoestrogen effects and research
- Curcumin's Biomedical Applications
- Energy, Environment, Economic Growth
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Air Quality and Health Impacts
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Adipose Tissue and Metabolism
- Cardiac Imaging and Diagnostics
- Advanced battery technologies research
- Advanced MRI Techniques and Applications
- Glutathione Transferases and Polymorphisms
- Muscle metabolism and nutrition
- Circadian rhythm and melatonin
Rutgers, The State University of New Jersey
2018-2025
Kunming Medical University
2022-2025
Xinqiao Hospital
2023-2024
Harbin Medical University
2010-2024
Army Medical University
2023-2024
Jilin University
2024
State Key Laboratory of Superhard Materials
2024
Bristol-Myers Squibb (United States)
2024
Southwest Hospital
2024
Nanjing Forestry University
2023
The urgent demand of scalable hydrogen production has motivated substantial research on low cost, efficient and robust catalysts for water electrolysis. In order to replace noble metals their derivatives, transition metal (Fe, Co, Ni, Mo, Cu, etc.) selenides have demonstrated promising catalysis both oxygen evolutions. Very recently, a number reports presented variety approaches enhance electrocatalytic activity. This review summarizes the most recent progress in selenide electrocatalysts...
Monocyte-derived tumor-associated macrophages (Mo-TAMs) intensively infiltrate diffuse gliomas with remarkable heterogeneity. Using single-cell transcriptomics, we chart a spatially resolved transcriptional landscape of Mo-TAMs across 51 patients isocitrate dehydrogenase (IDH)-wild-type glioblastomas or IDH-mutant gliomas. We characterize Mo-TAM subset that is localized to the peri-necrotic niche and skewed by hypoxic cues acquire hypoxia response signature. Hypoxia-TAM destabilizes...
Heme oxygenase-1 (HO-1) has been implicated in cardiac dysfunction, oxidative stress, inflammation, apoptosis and autophagy associated with heart failure, atherosclerosis, addition to its recognized role metabolic syndrome diabetes. Numerous studies have presented contradictory findings about the of HO-1 diabetic cardiomyopathy (DCM). In this study, we explored myocardial myofibril structure, using a streptozotocin (STZ)-induced diabetes model mice systemically overexpressing (Tg-HO-1) or...
In this work, we developed a new antibody-targeted and redox-responsive drug delivery system "MSNs-CAIX" by binding the anti-carbonic anhydrase IX antibody (A-CAIX Ab) on surface of mesoporous silica nanoparticles (MSNs) via disulfide linkages. The design composite particles involved synthesis functionalization with thiol groups, 2,2'-dipyridyl CAIX antibody. vitro, capping doxorubicin hydrochloric (DOX)-loaded (DOX@MSNs-CAIX) exhibited effectively release in presence glutathione (GSH) owing...
Butyrate (B) is a short-chain fatty acid produced by dietary fiber, known to inhibit histone deacetylases (HDACs) and possess cancer-preventive/anticancer effects. However, the role of B in metabolic rewiring, epigenomic reprogramming, transcriptomic network, NRF2 signaling, eliciting cancer-preventive effects colorectal cancer (CRC) HCT116 cell remains unclear.Sodium butyrate (NaB) dose-dependently inhibits growth CRC cells. NaB NRF2/NRF2-target genes blocks NRF2-ARE signaling. increases...
Anti–PD-1/PD-L1 therapy, either by anti–PD-1 antibody or anti–PD-L1 antibody, has efficacy reinvigorating tumor-infiltrating CD8 + T cells in a subset of patients with cancer, but it unequal effects on heterogeneous cell populations. Hence, the crucial to efficacious PD-1 blockade therapy remains elusive. Here, we found an increase CD200 cytotoxic lymphocytes (CTLs) upon PD-1/PD-L1 blockade, higher proportions positively related favorable clinical outcome anti–PD-1/PD-L1 three independent...
Abstract Understanding the connection between senescence phenotypes and mitochondrial dysfunction is crucial in aging premature diseases. Loss of function leads to a decline T cell function, which plays significant role this process. However, more research required determine if improving homeostasis alleviates phenotypes. Our has shown an association NAD + senescent cells through cGAS‐STING pathway, can lead inflammatory phenotype. Further needed fully understand T‐cell how it be utilized...
Abstract Background Cancer is the leading cause of death among older adults. Although integration immunotherapy has revolutionized therapeutic landscape cancer, complex interactions between age and efficacy remain incompletely defined. Here, we aimed to elucidate relationship aging resistance. Methods Flow cytometry was performed evaluate infiltration immune cells in tumor microenvironment (TME). In vivo T cell proliferation, cytotoxicity migration assays were antitumor capacity...
To satisfy the ever-growing demands for high energy density electrical vehicles and large-scale storage systems, thick electrode has been proposed proven to be an effective way achieve density. However, electrochemical performance of is hindered by inferior mechanical stabilities, poor charge transport kinetics, severe lithiation heterogeneities anabatic thermal risks, which block its step commercialization. Herein, we reviewed crucial issues arising in electrode, provided latest insights...
Curcumin is a major component of the spice turmeric (Curcuma longa), often used in food or as dietary supplement. Many preclinical studies on curcumin suggest health benefits many diseases due to its antioxidant/anti-inflammatory and epigenetic effects. The few human curcumin's unfavorable pharmacokinetics (PK) have limited potential, leading researchers study develop formulations improve PK. purpose this clinical describe acute pharmacodynamics (PK/PD) commercially marketed normal, healthy...
Over the past four decades, China have experienced rapid economic growth but also a widening urban-rural income gap and deteriorating air quality. Based on panel data of 30 provinces in from 2006 to 2017, this paper investigates effect narrowing carbon emission reduction pollution control by using OLS method. The empirical results indicate that: has positive impact control, while there are regional differences reduction. In perspective whole country central western regions, is conducive...
Ursolic acid (UA) is a triterpenoid phytochemical with strong anticancer effect. The metabolic rewiring, epigenetic reprogramming, and chemopreventive effect of UA in prostate cancer (PCa) remain unknown. Herein, we investigated the efficacy PCa xenograft, its biological effects on cellular metabolism, DNA methylation, transcriptomic using multi-omics approaches. metabolomics was quantified by liquid-chromatography-mass spectrometry (LC-MS) while epigenomic CpG methylation parallel gene...
Abstract The relentless pursuit of sustainable and safe energy storage technologies has driven a departure from conventional lithium‐based batteries toward other relevant alternatives. Among these, aqueous have emerged as promising candidate due to their inherent properties being cost‐effective, safe, environmentally friendly, scalable. However, traditional systems faced limitations stemming water's narrow electrochemical stability window (~1.23 V), severely constraining density viability in...
Abstract Background & Aims Several studies have shown that miR‐320a induces apoptosis, inhibits cell proliferation, and affects cycle progression as a tumour suppressor in many cancers. However, the involvement of invasion metastasis hepatocellular carcinoma ( HCC ) is still unknown. Methods Endogenous high mobility group box 1 HMGB 1) expressions were assayed by real‐time PCR . Luciferase activities measured using dual‐luciferase reporter assay system. Western blots used to determine...