A5007730317- Galaxies: Formation, Evolution, Phenomena
- Astrophysical Phenomena and Observations
- Gamma-ray bursts and supernovae
- Astrophysics and Star Formation Studies
- Stellar, planetary, and galactic studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Astronomy and Astrophysical Research
- Astrophysics and Cosmic Phenomena
- Recommender Systems and Techniques
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Immune cells in cancer
- Astronomical Observations and Instrumentation
- Chemokine receptors and signaling
- Plant Water Relations and Carbon Dynamics
- Advanced Graph Neural Networks
- Optical Coatings and Gratings
- Single-cell and spatial transcriptomics
- Human Mobility and Location-Based Analysis
- Quantum Information and Cryptography
- Photonic and Optical Devices
- Laser-Matter Interactions and Applications
Army Medical University
2014-2024
Southwest Hospital
2014-2024
University of Science and Technology of China
2016-2024
Hunan University
2024
Shanghai Jiao Tong University
2024
Huawei Technologies (China)
2022-2023
Medical Architecture (United Kingdom)
2023
Huawei Technologies (Sweden)
2022
Chinese Academy of Sciences
2021
Guilin University of Technology
2019-2020
Monocyte-derived tumor-associated macrophages (Mo-TAMs) intensively infiltrate diffuse gliomas with remarkable heterogeneity. Using single-cell transcriptomics, we chart a spatially resolved transcriptional landscape of Mo-TAMs across 51 patients isocitrate dehydrogenase (IDH)-wild-type glioblastomas or IDH-mutant gliomas. We characterize Mo-TAM subset that is localized to the peri-necrotic niche and skewed by hypoxic cues acquire hypoxia response signature. Hypoxia-TAM destabilizes...
To determine the prognostic significance of miR-663 in glioblastoma, its effect tumor progression, and underlying mechanism.Specimens from 256 cases patients with glioma, including 239 follow-up information, were used to analyze association between patients' prognosis by Kaplan-Meier multivariate Cox regression analyses. The effects on glioblastoma cell proliferation invasion examined both vitro vivo. Bioinformatics prediction signal network analysis applied identify putative targets...
Abstract The broad Mg ii line in quasars has distinct variability properties compared with Balmer lines: it is less variable and usually does not display a “breathing” mode, the increase average cloud distance when luminosity increases. We demonstrate that these of can be reasonably well explained by simple locally optimally emitting (LOC) photoionization models, confirming earlier results. In fiducial LOC model, -emitting gas on more distant from ionizing source than H α /H β responds lower...
Abstract Purpose: To identify the miRNA regulators of C–X–C motif chemokine receptor 4 (CXCR4) and underlying mechanism as well therapeutic prognostic values in human glioblastoma (GBM). Experimental Design: profile analyses bioinformatics predictions were used to mediators CXCR4, which confirmed by luciferase reporter assay, Western blot assay immunohistochemistry. The effects miR-663 on CXCR4-mediated GBM malignancy investigated gain-of-function experiments. Orthotopic xenografts derived...
Active galactic nuclei (AGNs) have long been observed to "twinkle" (i.e., their brightness varies with time) on timescales from days years in the UV/optical bands. Such AGN variability is essential for probing physics of supermassive black holes (SMBHs), accretion disk, and broad-line region. Here we show that temperature fluctuations an which magnetically coupled corona, can account high-quality optical light curves. We calculate by considering gas accreted matter near SMBH. find resulting...
Quasar outflows may play a crucial role in regulating the host galaxy, although spatial scale of quasar remain major enigma, with their acceleration mechanism poorly understood. The kinematic information outflow is key to understanding its origin and mechanism. Here, we report galactocentric distances different components for both sample an individual quasar. We find that distance increases velocity, typical value from several parsecs more than one hundred parsecs, providing direct evidence...
Direct myocardial and vascular injuries due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-driven inflammation is the leading cause of cardiac injury associated with disease 2019 (COVID-19). However, in-depth knowledge characteristics heart affected by lacking. In this study, using a quantitative spatial proteomics strategy that combines comparative anatomy, laser-capture microdissection, histological examination, we establish region-resolved proteome map myocardia...
Tumour-associated macrophages (TAMs) abundantly infiltrate high-grade gliomas and orchestrate immune response, but their diversity in isocitrate dehydrogenase (IDH)-differential grade 4 remains largely unknown. This study aimed to dissect the transcriptional states, spatial distribution, clinicopathological significance of distinct monocyte-derived TAM (Mo-TAM) microglia-derived (Mg-TAM) clusters across glioblastoma-IDH-wild type astrocytoma-IDH-mutant-grade (Astro-IDH-mut-G4). Single-cell...
Building appropriate scenarios to meet the personalized demands of different user groups is a common practice. Despite various scenario brings service, it also leads challenges for recommendation on multiple scenarios, especially with limited traffic. To give desirable service all and reduce cost resource consumption, how leverage information from construct unified model becomes critical. Unfortunately, performance existing multi-scenario approaches poor since they introduce unnecessary...
Bioorthogonal drug molecules are currently gaining prominence for their excellent efficacy, safety and metabolic stability. Pharmacokinetic study is critical understanding mechanisms guiding pharmacotherapy, which primarily performed with liquid chromatography-mass spectrometry as the gold standard. For broader more efficient applications in clinics fundamental research, further advancements especially desired cheap portable instrumentation well rapid tractable pretreatment procedures....
Abstract Quasar outflows often consist of two clouds with velocity separations matching the doublet spacings common UV resonance transitions, a phenomenon known as line locking, which is commonly observed in quasar spectra. Multiple can be locked together through multi-ion doublets, forming “line-locking web.” In second paper TOLL project, we present discovery one largest webs” to date from Very Large Telescope UVES spectra QSO J151352+085555. We identify 12 associated narrow absorption...
The eROSITA bubbles are detected via the instrument with same name. northern bubble shows noticeable asymmetric features, including distortion to west and enhancement in eastern edge, while southern counterpart is significantly dimmer. Their origins debated. Here, we performed hydrodynamic simulations showing that favor a dynamic, circumgalactic medium wind model, but disfavor other mechanisms such as non-axisymmetric halo gas or tilted nuclear outflow. from east by north direction Galactic...
Abstract Changing look (CL) is a rare phenomenon of active galactic nuclei (AGNs) that exhibit emerging or disappearing broad lines accompanied by continuum variations on astrophysically short timescales (≲1 yr to few decades). While previous studies have found Balmer-line (broad H α and/or β ) CL AGNs, the Mg ii line persistent even in dim states. No unambiguous AGN has been reported date. We perform systematic search AGNs using multi-epoch spectra special population -emitters...
CTR prediction is essential for modern recommender systems. Ranging from early factorization machines to deep learning based models in recent years, existing methods focus on capturing useful feature interactions or mining important behavior patterns. Despite the effectiveness, we argue that these suffer risk of label sparsity (i.e., user-item are highly sparse with respect space), noise collected usually noisy), and underuse domain knowledge pairwise correlations between samples). To...
Quasar-driven outflows on galactic scales are a routinely invoked ingredient for galaxy formation models. We report the discovery of ionized gas nebulae surrounding three luminous red quasars at z ~ 0.4 from Gemini integral field unit observations. All these feature unprecedented pairs "superbubbles" extending ~20 kpc in diameter, and line-of-sight velocity difference between red- blueshifted bubbles reaches up to ~1200 km/s. Their spectacular dual-bubble morphology (in analogy "Fermi...
User Behavior Modeling (UBM) plays a critical role in user interest learning, which has been extensively used recommender systems. Crucial interactive patterns between users and items have exploited, brings compelling improvements many recommendation tasks. In this paper, we attempt to provide thorough survey of research topic. We start by reviewing the background UBM. Then, systematic taxonomy existing UBM works, can be categorized into four different directions including Conventional UBM,...
Abstract It is commonly accepted that outflows from the central regions of quasars play a substantial role in regulating global properties host galaxy. These are typically detected through blueshifted absorption lines. However, question remains whether observed with different line types indeed reflect same environmental or evolutionary stage In this study, we use Sloan Digital Sky Survey quasar catalog and employ flux ratio [O II ] [Ne V] emission lines as indicators to compare star...
Abstract We present an observational study of wind acceleration based on four low-ionization broad absorption line (BAL) quasars (J0136, J1238, J1259, and J1344). J0136 J1344 (group 1) are radio-quiet show large BAL-velocity shifts as opposed to stable line-locking associated lines (AALs). Notably, displays a linear relation between shift time interval over three consecutive epochs, characteristic compelling evidence for BAL acceleration. J1238 J1259 2) exhibit small along with...
Abstract We present a statistical analysis of the variability broad absorption lines (BALs) in quasars using large multi-epoch spectroscopic data set Sloan Digital Sky Survey Data Release 12 (SDSS DR12). divide sample into two groups according to pattern variation C iv BAL with respect that continuum: equivalent widths (EW) decreases (increases) when continuum brightens (dims) as group T1; and EW opposite relation T2. find T2 has significantly ( <?CDATA ${P}_{{\rm{T}}}\lt {10}^{-6}$?> ,...
Glioblastoma (GBM) is an aggressive primary brain tumor with unique immunity predominated by myeloid cells. GBM cells have been implicated to evade immune attack through hijacking myeloid-affiliated transcriptional programs establish immunosuppressive microenvironment. However, molecular features of immune-evading in heterogeneous GBMs and their interactions remain unclear. Herein, we employed single-cell RNA sequencing (scRNA-seq) bulk RNA-seq data develop silico method for delineating...