A5025684702- Estrogen and related hormone effects
- Head and Neck Cancer Studies
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Complement system in diseases
- Cancer-related molecular mechanisms research
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Cervical Cancer and HPV Research
- Ear and Head Tumors
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Virus-based gene therapy research
- Renal Diseases and Glomerulopathies
- Traffic control and management
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Breast Lesions and Carcinomas
- Neuroblastoma Research and Treatments
University of Wisconsin–Madison
2003-2025
Mianyang Central Hospital
2023-2025
University of Electronic Science and Technology of China
2025
Southern University of Science and Technology
2025
Yangzhou University
2024
Yunnan University
2024
University of Wisconsin Carbone Cancer Center
2017-2024
Army Medical University
2024
Southwest Hospital
2024
Brigham and Women's Hospital
2009-2023
Abstract Suppression of androgen production and function provides palliation but not cure in men with prostate cancer (PCa). Therapeutic failure progression to hormone-refractory PCa (HRPC) are often accompanied by molecular alterations involving the receptor (AR). In this study, we report novel forms AR alteration that prevalent HRPC. Through silico sequence analysis subsequent experimental validation studies, uncovered seven variant transcripts lacking reading frames for ligand-binding...
Abstract Continued androgen receptor (AR) signaling is an established mechanism underlying castration-resistant prostate cancer (CRPC), and suppression of remains a therapeutic goal CRPC therapy. Constitutively active splice variants (AR-Vs) lack the ligand-binding domain (AR-LBD), intended target deprivation therapies including such as abiraterone MDV3100. While canonical full-length (AR-FL) AR-Vs are both increased in CRPCs, their expression regulation, associated transcriptional programs,...
Androgen receptor (AR) is commonly expressed in breast cancers. However, the association between tumor AR status and cancer survival uncertain. Hence, we examined Nurses' Health Study (NHS).It was a prospective study of postmenopausal women enrolled with stage I to III diagnosed 1976 1997 followed from date diagnosis until January 1, 2008 or death. Analyses were conducted using Kaplan-Meier methods Cox proportional hazard models, determine outcomes adjusting for covariates.Among 1467...
Heat-shock factor 1 (HSF1) is the master transcriptional regulator of cellular response to heat and a wide variety other stressors. We previously reported that HSF1 promotes survival proliferation malignant cells. At this time, however, clinical prognostic significance in cancer unknown. To address issue breast samples from 1,841 participants Nurses’ Health Study were scored for levels nuclear HSF1. Associations status with parameters outcomes investigated by Kaplan–Meier analysis Cox...
Monocyte-derived tumor-associated macrophages (Mo-TAMs) intensively infiltrate diffuse gliomas with remarkable heterogeneity. Using single-cell transcriptomics, we chart a spatially resolved transcriptional landscape of Mo-TAMs across 51 patients isocitrate dehydrogenase (IDH)-wild-type glioblastomas or IDH-mutant gliomas. We characterize Mo-TAM subset that is localized to the peri-necrotic niche and skewed by hypoxic cues acquire hypoxia response signature. Hypoxia-TAM destabilizes...
Abstract BACKGROUND The diversity and complexity of the human androgen receptor (AR) splicing variants are well appreciated but not fully understood. goal this study is to generate a comprehensive expression signature AR in castration‐resistant prostate cancer (CRPC), address relative importance individual conferring phenotype. METHODS A modified RNA amplification method, termed selective linear sense RNA, was developed amplify all transcripts containing exon 3 CRPC specimens, which were...
Accurate classification is essential for understanding the pathophysiology of a disease and can inform therapeutic choices. For hematopoietic malignancies, scheme based on phenotypic similarity between tumor cells normal has been successfully used to define subtypes; however, use cell types as reference by which classify solid tumors not widely emulated, in part due more limited epithelial differentiation compared with hematopoiesis. To provide better definition subtypes comprising breast...
Estrogen receptor (ER) and progesterone (PR) testing are performed in the evaluation of breast cancer. While clinical utility ER as a predictive biomarker to identify patients likely benefit from hormonal therapy is well-established, added value PR less well-defined. The primary goals our study were assess distribution, inter-assay reproducibility, prognostic significance cancer subtypes defined by patterns expression. We integrated gene expression microarray (GEM) clinico-pathologic data 20...
EZH2 mediates both PRC2-dependent gene silencing via catalyzing H3K27me3 and PRC2-independent transcriptional activation in various cancers. Given its oncogenic role cancers, has constituted a compelling target for anticancer therapy. However, current inhibitors only methyltransferase activity to downregulate levels show limited efficacy because of inadequate suppression the activity. Therefore, therapeutic strategies completely block are urgently needed. Herein, we report series...
Abstract Prostate cancer (PCa) is an extremely common genitourinary malignancy among elderly men. Many evidence have shown the efficacy of curcumin (CUR) in inhibiting progression PCa. However, pharmacological function CUR PCa still not quite clear. In this research, was found to suppress proliferation and enhance apoptotic rate vitro cell models a dose‐ time‐dependent manner. xenograft animal model, administration contributed significant decrease growth tumor induced by transplanted PC‐3...
ADAR is highly expressed and correlated with poor prognosis in hepatocellular carcinoma (HCC), yet the role of its constitutive isoform ADARp110 tumorigenesis remains elusive. We investigated HCC underlying mechanisms using clinical samples, a hepatocyte-specific Adarp110 knock-in mouse model, engineered cell lines. overexpressed associated survival both human HCC. It creates an immunosuppressive microenvironment by inhibiting total immune cells, particularly cytotoxic GZMB+CD8+ T cells...
Rac1 is a small GTPase that regulates the actin cytoskeleton but also other cellular processes. To investigate function of in skin, we generated mice with keratinocyte-restricted deletion rac1 gene. Rac1-deficient lost nearly all their hair within few weeks after birth. The nonpermanent part mutant follicles developed constrictions; expression follicle-specific keratins, E-cadherin, and α6 integrin; was eventually removed by macrophages. permanent sebaceous glands were maintained, no...
The Gleason grading system has been the most reliable tool for prognosis of prostate cancer since its development. However, clinical application remains limited by interobserver variability in and quantification, which negative consequences risk assessment management cancer.To examine impact an artificial intelligence (AI)-assisted approach to quantification.This diagnostic study was conducted at University Wisconsin-Madison from August 2, 2017, December 30, 2019. chronologically selected...
The frequency and proliferative activity of tissue-specific stem progenitor cells are suggested to correlate with cancer risk. In this study, we investigated the association between breast risk mammary epithelial expressing p27, estrogen receptor (ER), Ki67 in normal tissue. We performed a nested case-control study 302 women (69 cases, 233 controls) who had been initially diagnosed benign disease according Nurses' Health Studies. Immunofluorescence for ER, was on tissue microarrays...
Abstract Purpose: We investigated whether in human head and neck squamous cell carcinoma (HNSCC) high levels of expression stress keratin 17 (K17) are associated with poor survival resistance to immunotherapy. Experimental Design: the role K17 regulating both tumor microenvironment immune responsiveness HNSCC using a syngeneic mouse model, MOC2. MOC2 gives rise immunologically cold tumors that resistant immune-checkpoint blockade (ICB). engineered multiple, independent knockout (KO) lines...