A5065834398- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Advanced Glycation End Products research
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Cancer and Skin Lesions
- Inflammatory mediators and NSAID effects
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Gene expression and cancer classification
- Click Chemistry and Applications
- 3D Printing in Biomedical Research
- Caveolin-1 and cellular processes
- Phagocytosis and Immune Regulation
- S100 Proteins and Annexins
- Ferroptosis and cancer prognosis
University of Miami
2013-2022
Sylvester Comprehensive Cancer Center
2019
Accurate classification is essential for understanding the pathophysiology of a disease and can inform therapeutic choices. For hematopoietic malignancies, scheme based on phenotypic similarity between tumor cells normal has been successfully used to define subtypes; however, use cell types as reference by which classify solid tumors not widely emulated, in part due more limited epithelial differentiation compared with hematopoiesis. To provide better definition subtypes comprising breast...
Abstract Background Pancreatic cancer is one of the most difficult cancers to detect early and patients die from complications arising due distant organ metastases. The lack bona fide biomarkers primary reasons for late diagnosis pancreatic cancer. It a multifactorial disease warrants novel approach identify biomarkers. Methods In order characterize proteome, Extracellular vesicles (EVs) isolated different in vitro conditions mimicking tumor-microenvironment interactions between epithelial...
Background: Current strategies in circulating tumor cell (CTC) isolation pancreatic cancer heavily rely on the EpCAM and cytokeratin status. is generally not considered a good marker given its transitory change during Epithelial to Mesenchymal Transition (EMT) or reverse EMT. There need identify other surface markers capture complete repertoire of PDAC CTCs. The primary objective study characterize alternate biomarkers CTCs that express low negligible levels patients. Methods: Flow cytometry...
Background: Current strategies in circulating tumor cell (CTC) isolation pancreatic cancer heavily rely on the EpCAM and cytokeratin status. is generally not considered as a good marker given its transitory change during Epithelial to Mesenchymal Transition (EMT) or reverse EMT. There need identify other surface markers capture complete repertoire of PDAC CTCs. The primary objective study characterize alternate bi-omarkers CTCs that express low negligible levels pancre-atic patients....
Abstract Breast cancer is most common malignant state in women, with 20% of these patients developing metastasis during the course their disease. Further understanding needed process and mechanisms metastasis. Our lab others have been shown that Receptor Advanced-Glycation End-products (RAGE) plays a role tumorigenesis RAGE highly expressed various cancers including breast its protein levels correlate poor patient outcome other cancers. Activation results increased proliferation, migration...
Abstract Background: Breast cancer is most common malignant state in women and 20% of these patients will develop metastasis during the course their disease. Further understanding needed process mechanisms metastasis. Our lab others have been shown that Receptor Advanced-Glycation End-products (RAGE) plays a role tumorigenesis RAGE highly expressed various cancers including breast its protein levels correlate with poor patient outcome other cancers. Activation results increased...
Abstract The classification of lymphoma and leukemia is successfully done by using normal cell types as a reference point which one the many reasons that better therapies are available for their treatment. In case breast cancer, clinically it classified Estrogen Receptor positive, Human Epidermal Growth Factor 2 (Her2) positive triple negative cancer while in research settings, has been mRNA expression profiling but these systems still evolving. Our laboratory attempted to classify examining...
Abstract Background: The Receptor for Advanced-Glycation End-products (RAGE) is highly expressed in various cancers and its expression correlated with poorer outcomes breast cancer. We have previously implicated RAGE cancer, but whether drives cancer progression metastasis either through tumor cell intrinsic effects, non-tumor cells of the microenvironment, or both, not fully understood. More importantly, studies are lacking that target therapeutically may therefore represent a novel...