A5010383900- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Esophageal and GI Pathology
- Immune cells in cancer
- Hernia repair and management
- Foreign Body Medical Cases
- Intestinal Malrotation and Obstruction Disorders
- Monoclonal and Polyclonal Antibodies Research
- Chemokine receptors and signaling
- Extracellular vesicles in disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital gastrointestinal and neural anomalies
- Cancer, Stress, Anesthesia, and Immune Response
- Epigenetics and DNA Methylation
- Inflammatory Bowel Disease
- Child Abuse and Trauma
- Homicide, Infanticide, and Child Abuse
- Hip and Femur Fractures
- Phagocytosis and Immune Regulation
- Congenital Diaphragmatic Hernia Studies
Phoenix Children's Hospital
2024
Mayo Clinic in Florida
2024
Sylvester Comprehensive Cancer Center
2018-2022
University of Miami
2018-2022
University of Alabama at Birmingham
2021
Jackson Memorial Hospital
2020
Leiden University Medical Center
2019
King Saud University
2019
Pancreatic ductal adenocarcinoma (PDAC) is considered to be a highly immunosuppressive and heterogenous neoplasm. Despite improved knowledge regarding the genetic background of tumor better understanding microenvironment, immune checkpoint inhibitor therapy (targeting CTLA4, PD1, PDL1) has not been very successful against PDAC. The robust desmoplastic stroma, along with an extensive extracellular matrix (ECM) that rich in hyaluronan, plays integral role this evasion. Hexosamine biosynthesis...
Despite decades of research, there is no specific therapy for acute pancreatitis (AP). In the current study, we have evaluated efficacy pirfenidone, an antiinflammatory and antifibrotic agent that approved by FDA treatment idiopathic pulmonary fibrosis (IPF), in ameliorating local systemic injury AP. Our results suggest with pirfenidone therapeutic settings (e.g., after initiation injury), even when administered at peak injury, reduces severity inflammation multiple models vitro evaluation...
Abstract Background Pancreatic cancer is one of the most difficult cancers to detect early and patients die from complications arising due distant organ metastases. The lack bona fide biomarkers primary reasons for late diagnosis pancreatic cancer. It a multifactorial disease warrants novel approach identify biomarkers. Methods In order characterize proteome, Extracellular vesicles (EVs) isolated different in vitro conditions mimicking tumor-microenvironment interactions between epithelial...
Abstract Vaccination of patients against neoantigens expressed in concurrent tumors, recurrent or tumors developing individuals at risk cancer is posing major challenges terms which antigens to target and limited expressing their tumors. Here, we describe a vaccination strategy that were induced tumor cells by downregulation the peptide transporter associated with antigen processing (TAP). TAP downregulation–induced was more effective than mutation-derived neoantigens, devoid measurable...
Introduction: Surgery remains an important treatment modality for the management of pediatric Crohn's disease (CD). The objective this study was to perform a comparative analysis open right hemicolectomy (ORH) and laparoscopic (LRH) CD. Materials Methods: Kids' Inpatient Database (KID) queried (2009–2012) ICD-9 procedure codes ORH (45.73) LRH (17.33) in patients with CD (ICD-9 codes: 555.0, 555.1, 555.2, 555.9). Open procedures were compared using propensity score (PS)-matched (PSMA) 41...
Heat shock protein 70 (Hsp70), a chaperone, is known to promote cell survival and tumor progression. However, its role in the microenvironment (TME) largely unknown. We specifically evaluated Hsp70 TME by implanting tumors wild-type (WT) controls or Hsp70−/- animals, thus creating with without Hsp70. Loss of led significantly smaller tumors; there were no differences stromal markers, but interestingly, depletion CD8 + T-cells abrogated this suppressive effect, indicating that loss affects...
Ulcerative colitis (UC) is an aggressive disease in the pediatric population and a cause of significant, lifelong morbidity. The aim this study to compare surgical complications patients undergoing laparoscopic vs. open treatment for UC.We queried Kids' Inpatient Database (KID) all cases UC 2009 2012. We identified who received total colectomy without proctectomy (n=413) or proctocolectomy (n=196) performed univariate multivariate analyses comparing procedures.In proctectomy, procedures were...
Methods: An IRB approved retrospective chart review of patients aged 5 to 21 years who underwent operative treatment with initial subtotal colectomy (STC), followed by a total proctocolectomy IPAA +/-diversion for medically refractory IBD from January 2010 August 2018 (n = 25).Fisher's exact test was used statistical analysis.Results: The average age at the time 13.4 -3.4 years.Patients were predominately male (53.8%) and Caucasian (53.8%).Indication STC ulcerative colitis in 84.6% patients,...
Laparoscopic approach for the surgical management of familial adenomatous polyposis (FAP) has become increasingly common pediatric patients. The purpose this study was to compare short-term outcomes and resource utilization between open laparoscopic surgery prophylactic colectomy in children with FAP.The Kids' Inpatient Database (2009 2012) analyzed (age ≤20 years) FAP that underwent total or proctocolectomy. Patient demographics, treating hospital characteristics, charges, were compared...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is considered to be a highly immunosuppressive and heterogenous neoplasm. Despite improved knowledge regarding the genetic background of tumor better understanding microenvironment, immune checkpoint inhibitor therapy (targeting CTLA-4, PD-1, PD-L1) has not been very successful against PDAC. The robust desmoplastic stroma, along with an extensive extracellular matrix (ECM) that rich in hyaluronan, plays integral role this evasion. Hexosamine...