A5030291750- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Nanoparticle-Based Drug Delivery
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Nanoparticles: synthesis and applications
- Phagocytosis and Immune Regulation
- Pancreatic function and diabetes
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Nanomaterials for catalytic reactions
- Virus-based gene therapy research
- Cancer, Lipids, and Metabolism
- Plant tissue culture and regeneration
- Plant Reproductive Biology
- Natural Compounds in Disease Treatment
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Plant Molecular Biology Research
Chandigarh University
2024
Galgotias University
2024
Amity University
2024
Sylvester Comprehensive Cancer Center
2017-2023
University of Miami
2017-2023
Central Institute for Research on Goats
2023
University of Minnesota
2016-2023
Delhi Technological University
2021-2023
Motilal Nehru National Institute of Technology
2023
University of Delhi
2018-2022
Pancreatic ductal adenocarcinoma (PDAC) is considered to be a highly immunosuppressive and heterogenous neoplasm. Despite improved knowledge regarding the genetic background of tumor better understanding microenvironment, immune checkpoint inhibitor therapy (targeting CTLA4, PD1, PDL1) has not been very successful against PDAC. The robust desmoplastic stroma, along with an extensive extracellular matrix (ECM) that rich in hyaluronan, plays integral role this evasion. Hexosamine biosynthesis...
ABSTRACT Several innate sensing pathways contribute to the control of early cytomegalovirus (CMV) infection, leading a multiphasic type I interferon (IFN-I) response that limits viral replication and promotes host defenses. Toll-like receptor (TLR)-dependent induce IFN-I production in CMV-infected plasmacytoid dendritic cells; however, initial burst occurs within first few hours vivo is TLR independent emanates from stromal cells. Here we show primary human endothelial cells mount robust...
Abstract Resident fibroblasts that contact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts (CAF) stimulate oncogenic signaling in TEC. In this study, we evaluated the cross-talk between CAF and TEC isolated from tumors generated a mouse model of KRAS/mut p53-induced pancreatic cancer (KPC mice). Transcriptomic profiling conducted after treatment with anticancer compound Minnelide revealed deregulation TGFβ pathway CAF, resulting an apparent...
Abstract Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) signaling have been shown to be dysregulated in multiple cancer types. Glucose regulatory 78 (GRP78), master regulator of UPR, plays a role proliferation, invasion, metastasis cancer. Cancer stem cells (CSCs) make up crucial component tumor heterogeneity pancreatic cancer, as well other cancers. “Stemness” defines population within that increased therapeutic resistance survival advantage. In current study, we...
Abstract The present study aims at developing PGMD (poly-glycerol-malic acid-dodecanedioic acid)/curcumin nanoparticles based formulation for anticancer activity against breast cancer cells. were prepared using both the variants of polymer (PGMD 7:3 and 6:4) with curcumin (i.e. CUR NP 6:4). size 6:4 found to be ~ 110 218 nm a polydispersity index 0.174 0.36, respectively. Further, zeta potential particles was − 18.9 17.5 mV 6:4, entrapment efficiency in range 75–81%. In vitro scratch assay...
Abstract In pancreatic cancer, the robust fibroinflammatory stroma contributes to immune suppression and renders tumors hypoxic, altering intratumoral metabolic pathways leading poor survival. One enzyme activated during hypoxia is lactate dehydrogenase A (LDHA). As a result of its promiscuous activity under hypoxia, LDHA produces L-2 hydroxyglutarate (L-2HG), an epigenetic modifier, that regulates tumor transcriptome. However, role L-2HG in remodeling microenvironment not known. Here we...
Pancreatic adenocarcinoma (PDAC) claims more than 90% of the patients diagnosed with disease owing to its aggressive biology that is manifested by high rate tumor recurrence.Aberrant upregulation in transcriptional activity proteins involved self-renewal like Sox2, Oct4 and Nanog instrumental these recurrence phenomena.In cancer, Sox2 aberrantly "turned-on" leading activation downstream genes those results relapse tumor.Molecular mechanisms regulate PDAC are not known.In current study, we...
Abstract Tumor-initiating cells (TIC) have been implicated in pancreatic tumor initiation, progression, and metastasis. Among different markers that define this cell population within the tumor, CD133+ cancer stem (CSC) has reliably described these processes. CD133 expression also shown to functionally promote metastasis through NF-κB activation population, but mechanism is unclear. In current study, overexpression of increased secretion IL1β (IL1B), which activates an autocrine signaling...
Pancreatic tumors are renowned for their extremely hypoxic centers, resulting in upregulation of a number hypoxia mediated signaling pathways including cell proliferation, metabolism and survival. Previous studies from our laboratory have shown that Minnelide, water-soluble pro-drug triptolide (anti-cancer compound), decreases viability cancer cells vitro as well vivo. However, its mechanism action remain elusive. In the current study we evaluated effect on oncogenic stemness pancreatic...
Chemoresistance is a major therapeutic challenge that plays role in the poor statistical outcomes pancreatic cancer. Unfolded protein response ( UPR ) one of homeostasis mechanisms cancer cells have been correlated with chemoresistance number cancers including In this study, we show modulating glucose regulatory 78 GRP 78), master regulator , can profound effect on multiple pathways mediate chemoresistance. Our study showed for first time silencing diminish efflux activity ATP ‐binding...
Silver nanoparticles have been widely studied to possess antimicrobial as well anticancer activity, and found its applications in various fields including pharmaceutical industry, diagnostics, drug delivery, food others. For this purpose, several cell proliferation assays are used for the evaluation of activity synthetic compounds natural plant extracts. In general, a compound is said an if it prevents cancer cells grow divide actively, indirectly activates generic program death. protocol,...
Pancreatic adenocarcinoma is a devastating disease with an abysmal survival rate of 9%. A robust fibro-inflammatory and desmoplastic stroma, characteristic pancreatic cancer, contribute to the challenges in developing viable therapeutic strategies this disease. Apart from constricting blood vessels preventing efficient drug delivery tumor, stroma also contributes aggressive biology cancer along its immune-evasive microenvironment. In study, we show that tumors, increases tumor initiation...
Combination therapy using chemically distinct drugs has appeared as one of the promising strategies to improve anticancer treatment efficiency. In present investigation, poly-(lactic-co-glycolic) acid (PLGA) nanoparticles electrostatically conjugated with polyethylenimine (PEI)-based co-delivery system for epirubicin and paclitaxel (PLGA-PEI-EPI-PTX NPs) been developed. The PLGA-PEI-EPI-PTX NPs exhibited a monodispersed size distribution an average 240.93 ± 12.70 nm measured through DLS...
Abstract Endoplasmic reticulum (ER) stress initiates an important mechanism for cell adaptation and survival, named the unfolded protein response (UPR). Severe or chronic/prolonged UPR can breach threshold survival lead to death. There is a fundamental gap in knowledge on molecular of how chronic ER stimulated leads death pancreatic ductal adenocarcinoma (PDAC). Our study shows that downregulating specificity 1 (Sp1), transcription factor overexpressed cancer, activates results stress. In...