A5077141651- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Plant Toxicity and Pharmacological Properties
- Heat shock proteins research
- Pancreatic function and diabetes
- Natural Compounds in Disease Treatment
- Cell death mechanisms and regulation
- Drug-Induced Hepatotoxicity and Protection
- Endoplasmic Reticulum Stress and Disease
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Drug Transport and Resistance Mechanisms
- Diabetes and associated disorders
- Apelin-related biomedical research
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Neuropeptides and Animal Physiology
- Pediatric Hepatobiliary Diseases and Treatments
- MicroRNA in disease regulation
- Gastrointestinal disorders and treatments
- Gut microbiota and health
- Ruminant Nutrition and Digestive Physiology
- Hepatitis B Virus Studies
- Cancer Mechanisms and Therapy
Sylvester Comprehensive Cancer Center
2017-2024
University of Miami
2016-2024
Miami University
2018
University of Minnesota
2006-2015
Twin Cities Orthopedics
2007-2013
University of Minnesota Medical Center
2013
University of Alabama at Birmingham
2008
University of Minnesota System
2008
Indian Veterinary Research Institute
1991-2006
University of Massachusetts Chan Medical School
2004-2006
Minnelide prevents tumor formation, causes regression, and increases survival in multiple models of pancreatic cancer.
Abstract Pancreatic cancer is highly resistant to current chemotherapy agents. We therefore examined the effects of triptolide (a diterpenoid triepoxide) on pancreatic growth and local-regional tumor spread using an orthotopic model cancer. have recently shown that increased level HSP70 in cells confers resistance apoptosis inhibiting induces these cells. In addition, was identified as part a small molecule screen, regulator human heat shock response. Therefore, our aims were examine (a) by...
Abstract Pancreatic carcinoma is a malignant disease that responds poorly to chemotherapy because of its resistance apoptosis. Heat shock proteins (Hsp) are not only cytoprotective but also interfere with the apoptotic cascade. Here, we investigated role Hsp70 in regulating apoptosis pancreatic cancer cells. expression was increased cells compared normal ductal This confirmed by mRNA levels for human tissue neighboring from same patient. Depletion quercetin decreased cell viability and...
The pathogenesis of acute pancreatitis is not fully understood. Experimental animal models that mimic human disease are essential to better understand the pathophysiology and evaluate potential therapeutic agents. Given mouse genome known completely a large number strains with various genetic deletions available, it advantageous have multiple reliable pancreatitis. Presently, there only one predominant model in mice, which hyperstimulatory doses cholecystokinin or its analog caerulein...
The purpose of this study was to evaluate the role <sup>68</sup>Ga-labeled DOTANOC PET/CT for baseline evaluation patients with head and neck paragangliomas (HNPs). <b>Methods:</b> data 26 (mean age ± SD, 34.3 10.4 y; 50% men) known or suspected HNPs who underwent <sup>68</sup>Ga-DOTANOC staging were retrospectively analyzed. performed after intravenous injection 132–222 MBq <sup>68</sup>Ga-DOTANOC. images evaluated by 2 experienced nuclear medicine physicians in consensus, both...
The pathogenesis of chronic pancreatitis (CP) is poorly understood. Endoplasmic reticulum (ER) stress has now been recognized as a pathogenic event in many diseases. However, ER not studied CP, although pancreatic acinar cells seem to be especially vulnerable dysfunction because their dependence on high volume and functionality. Here, we aim investigate study its relation trypsinogen activation (widely regarded the key pancreatitis), explore mechanism, time course, downstream consequences...
Opioids such as morphine are widely used for the management of pain associated with acute pancreatitis. Interestingly, opioids also known to affect immune system and modulate inflammatory pathways in non-pancreatic diseases. However, impact on progression pancreatitis has never been evaluated. In current study, we evaluated severity pancreatitis.Effect treatment caerulein, L-arginine ethanol-palmitoleic acid models was after induction disease. Inflammatory response, gut permeability...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Both Tannin and Protein in a Tannin-Protein ComplexPaul Makkar, Rajinder Dawra, Bhupinder SinghCite this: J. Agric. Food Chem. 1988, 36, 3, 523–525Publication Date (Print):May 1, 1988Publication History Published online10 January 2005Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/jf00081a600https://doi.org/10.1021/jf00081a600research-articleACS PublicationsRequest reuse permissionsArticle...