A5022951822- COVID-19 Clinical Research Studies
- Syphilis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Machine Learning in Bioinformatics
- Skin and Cellular Biology Research
- Cancer-related molecular mechanisms research
- Reproductive tract infections research
- Skin Protection and Aging
- Long-Term Effects of COVID-19
- Effects and risks of endocrine disrupting chemicals
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- melanin and skin pigmentation
- Hair Growth and Disorders
- Advanced Proteomics Techniques and Applications
- Cutaneous lymphoproliferative disorders research
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Development and Preterm Care
- Genital Health and Disease
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Peking Union Medical College Hospital
2020-2025
Tianjin haihe hospital
2024
Tianjin University of Traditional Chinese Medicine
2022-2024
University of California, San Francisco
2024
Zhejiang University
2022-2023
Tianjin Medical University
2008-2021
Nanjing University of Posts and Telecommunications
2021
Beijing Proteome Research Center
2012-2020
Amazon (Germany)
2020
Background Subjective cognitive impairment (SCI) in older persons without manifest symptomatology is a common condition with largely unclear prognosis. We hypothesized that (1) examining outcome for sufficient period by using conversion to mild (MCI) or dementia would clarify SCI prognosis, and (2) the aforementioned procedures, prognosis of subjects differ significantly from demographically matched healthy subjects, free SCI, termed no (NCI) subjects. Methods A consecutive series aged ≥40...
Abstract The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics pathological features underlying remain largely unknown. To characterize mechanisms pathogenesis in lung tissue using proteomic approach, fresh tissues were obtained from newly deceased patients pneumonia. After virus inactivation, quantitative approach combined bioinformatics analysis was used detect changes...
In light of the rapid accumulation large-scale omics datasets, numerous studies have attempted to characterize molecular and clinical features cancers from a multi-omics perspective. However, there are great challenges in integrating using machine learning methods for cancer subtype classification. this study, MoGCN, integration model based on graph convolutional network (GCN) was developed classification analysis. Genomics, transcriptomics proteomics datasets 511 breast invasive carcinoma...
Abstract Human skin comprises stratified squamous epithelium and dermis with various stromal cells the extracellular matrix (ECM). The basement membrane (BM), a thin layer at top of dermis, serves as unique niche for determining fate epidermal stem (EpSCs) by transmitting physical biochemical signals to establish cell polarity maintain hierarchical structure function tissue. However, how niches tissue homeostasis control wound healing regulating behavior EpSCs is still not completely...
Severe neurological symptoms are associated with Coronavirus disease 2019 (COVID-19). However, the morphologic features, pathological nature and their potential mechanisms in patient brains have not been revealed despite evidence of neurotropic infection. In this study, neuropathological damages infiltrating inflammatory cells were quantitatively evaluated by immunohistochemical staining, ultrastructural examination under electron microscopy, an image threshold method, postmortem from nine...
Background Intranasal transplantation of ANGE-S003 human neural stem cells showed therapeutic effects and were safe in preclinical models Parkinson’s disease (PD). We investigated the safety tolerability this treatment patients with PD whether these would be apparent a clinical trial. Methods This was 12-month, single-centre, open-label, dose-escalation phase 1 study 18 advanced assigned to four-time intranasal 3 doses: 1.5 million, 5 million or 15 evaluate their efficacy. Results 7...
Protein clustering/disassembling is a fundamental process in biomolecular condensates, playing crucial roles cell fate decision and cellular homeostasis. However, the inherent features of protein clustering, especially for its reversible behavior subtle microenvironment variation, present significant hurdles probe chemistry tracking clustering dynamics. Herein, we report bilateral‐tailored chemigenetic probe, which an "amphiphilic" AIEgen QMSO3Cl covalently conjugated to tag that genetically...
Direct myocardial and vascular injuries due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-driven inflammation is the leading cause of cardiac injury associated with disease 2019 (COVID-19). However, in-depth knowledge characteristics heart affected by lacking. In this study, using a quantitative spatial proteomics strategy that combines comparative anatomy, laser-capture microdissection, histological examination, we establish region-resolved proteome map myocardia...
Abstract Neurosyphilis (NS) is a central nervous system (CNS) infection caused by Treponema pallidum ( T. ). NS can occur at any stage of syphilis and manifests as broad spectrum clinical symptoms. Often referred to “the great imitator,” be easily overlooked or misdiagnosed due the absence standard diagnostic tests, potentially leading severe irreversible organ dysfunction. In this study, proteomic machine learning model techniques are used characterize 223 cerebrospinal fluid (CSF) samples...
Coronavirus disease 2019 (COVID-19) patients with impact on skin and hair loss are reported. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is detected in the of some patients; however, detailed pathological features tissues from infected SARS-CoV-2 at a molecular level limited. Especially, ability to infect cells their function not well understood. A proteome map COVID-19 established here susceptibility human-induced pluripotent stem cell (hiPSC)-derived organoids follicles...
Abstract Localized scleroderma (LoS) is a rare chronic disease with extensive tissue fibrosis, inflammatory infiltration, microvascular alterations, and epidermal appendage lesions. However, deeper understanding of the pathogenesis treatment strategies LoS currently limited. In present work, proteome map skin established, pathological features are characterized. Most importantly, human‐induced pluripotent stem cell‐derived epithelial mesenchymal (EM) organoids model in 3D culture system for...
STAT3 is a key transcription factor that mediates various cellular and organismal processes, such as cell growth, apoptosis, immune response cancer. However, the molecular mechanisms of regulation remain poorly understood. Here, we identified TRAF6 new interactor. augmented ubiquitination deactivated its transcriptional activity induced by IFNα stimulation or overexpressed with JAK2. Both RING domain TRAF-type zinc finger were indispensable for deactivation. Accordingly, also down-regulated...
Abstract To determine the preliminary effectiveness of breast cancer screening among Chinese females, 1226714 women aged 35–69 years first received clinical examinations. Urban with suspected mammography followed by ultrasound (BUS), while rural underwent BUS mammography. After one-year follow-up, 223 and 431 cancers were detected urban (respectively), overall detection rates 0.56/1000 0.52/1000. Higher significantly associated older age at for both women; additionally, higher risk if they...
Previous observational studies reported altered melanoma risks in relation to many potential factors, such as coffee intake, smoking habits and photodamage-related conditions. Considering the susceptibility of epidemiological residual confounders, there remains uncertainty about actual causal roles these factors aetiology.This study aims investigate association between cutaneous (CM) previously factors: alcohol consumption, lifetime smoking, socioeconomic status (SES), ease skin tanning,...
Frostbite is the most common cold injury and caused by both immediate cold-induced cell death gradual development of localized inflammation tissue ischemia. Delayed healing frostbite often leads to scar formation, which not only causes psychological distress but also tends result in secondary malignant tumors. Therefore, a rapid method for wounds urgently needed. Herein, we used mouse skin model evaluate recovery process after frostbite. Moreover, single-cell transcriptomics was determine...
Protein clustering/disassembling is a fundamental process in biomolecular condensates, playing crucial roles cell fate decision and cellular homeostasis. However, the inherent features of protein clustering, especially for its reversible behavior subtle microenvironment variation, present significant hurdles probe chemistry tracking clustering dynamics. Herein, we report bilateral‐tailored chemigenetic probe, which an "amphiphilic" AIEgen QMSO3Cl covalently conjugated to tag that genetically...
ABSTRACT Background Alopecia areata (AA) is a chronic autoimmune disorder characterized by non‐scarring hair loss, affecting approximately 2% of the global population. Its etiology involves genetic, immunological, and environmental factors, with significant psychological impacts such as anxiety depression. However, international trends comorbidity associations remain poorly understood. Aims This study aims to analyze in incidence prevalence AA assess its major comorbidities across different...
Image‐based screening is an efficient drug discovery strategy. Combining high‐content (HCS) with artificial intelligence efficiently detects drug‐induced cellular phenotypes from a large pool of compounds. However, previous studies primarily focus on cell classification and cannot interpret models using morphological features. Additionally, the existing morphology‐based use only few features, which accurately characterize phenotypic perturbations. Herein, π‐PhenoDrug, deep learning‐based...
The EV-A71 poses a serious threat to the health and lives of children. can be transmitted by direct indirect skin contact. Therefore, there is an urgent need create novel models using human-derived cells study biology pathogenesis virus facilitate drug screening. Here, we use human induced pluripotent stem cells-derived organoids (hiPSC-SOs) as model for infection find that multiple cell types within organoids, including epidermal cells, hair follicle fibroblasts, nerve express receptors are...