A5100662711- Renal cell carcinoma treatment
- Thyroid Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Renal and related cancers
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Prostate Cancer Treatment and Research
- Renal and Vascular Pathologies
- Pregnancy and preeclampsia studies
- AI in cancer detection
- Gastric Cancer Management and Outcomes
- Pharmaceutical and Antibiotic Environmental Impacts
- Endometrial and Cervical Cancer Treatments
- Neonatal Health and Biochemistry
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Phytochemical Studies and Bioactivities
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Thyroid Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Ovarian cancer diagnosis and treatment
Peking University Third Hospital
2012-2024
Peking University
2012-2024
Fujian Agriculture and Forestry University
2024
Alibaba Group (United States)
2024
Beijing Center for Disease Prevention and Control
2020-2024
Tibet Autonomous Region People's Hospital
2024
Chongqing Medical University
2024
China Medical University
2023
Northwest University
2023
Army Medical University
2023
Background/Aims: Melatonin, synthesized by the pineal gland and released into blood, appears to have antitumour properties; however, mechanisms of its anti-cancer effects are largely unknown, especially in stomach cancer. Here, we explore activity melatonin a gastric cancer cell line (AGS) analyse molecular mechanisms. Methods: AGS cells were treated with melatonin, viability was assessed using CCK-8 assay. Flow cytometry performed evaluate apoptosis, protein expression examined Western...
Circulating tumor cells (CTCs) are the seeds of distant metastases malignant tumors and associated with malignancy risk metastasis. However, undergo epithelial-mesenchymal transition (EMT) during metastasis, leading to emergence different types CTCs. Real-time dynamic molecular functional typing CTCs is necessary precisely guide personalized treatment. Most CTC detection systems based on epithelial markers that may fail detect EMT Therefore, it clinically important identify new types. In...
Mammographic density (MD) has not been systematically investigated among Chinese women. Breast cancer screening programmes provided detailed information on MD in a large number of asymptomatic women.In the Multi-modality Independent Screening Trial (MIST), we estimated association between and its influential factors using logistic regression, adjusting for age, body mass index (BMI) study area. Differences other ethnic groups with respect to were also explored adjustment age BMI.A total 28...
AbstractAutophagy-associated release of HMGB1 is known to protect cancer cells from many chemotherapeutics. However, the detailed molecular mechanism(s) responsible remains largely undefined. We show in this study that released into extracellular space protects gastric apoptosis induced by microtubule-targeting drug vincristine through transcriptional upregulation Mcl-1. Extracellular appeared essential for autophagy-mediated inhibition apoptosis, siRNA knockdown or its abolished protective...
Abstract Objective This study aimed to investigate the clinical significance of Krebs von den Lungen‐6 (KL‐6) serum levels in patients with anti‐MDA5 antibody‐positive dermatomyositis (anti‐MDA5 + DM) having interstitial lung disease (ILD), especially amyopathic DM phenotype. Methods The KL‐6 level was measured using a chemiluminescence enzyme immunoassay (CLEIA) DM, including clinically (CADM)‐ILD and classic DM‐ILD, healthy donors. baseline post‐treatment were determined 39 CADM‐ILD who...
Introduction Chronic kidney disease (CKD) is a chronic progressive characterized by abnormalities in structure or function caused variousfactors. It has become significant public health problem, posing threat to human worldwide. Shenshuaikang enema (SSKE) demonstrated notable efficacy and safety treating CKD, although its mechanism of action remains unclear. Methods The CKD rat model was induced using 2.5% adenine, the effect SSKE evaluated detecting uremic toxins, inflammatory cytokines,...
Introduction: Discordances of Gleason grade (GG) between biopsy and radical prostatectomy (RP) prostate cancer (PCa) patients have raised great concerns. Our study aimed to identify these predictive factors for GG upgrading from RP. Methods: We retrospectively reviewed the records PCa receiving RP in our medical center. All underwent a standardized 12‐core transrectal ultrasound (TRUS)–guided needle biopsy, with site‐specific submissions. Pretreatment PSA–related parameters were assessed 2...
This study examined the learning behaviors of higher-grade students (Grades 4-6) in after-class mathematics tutoring at primary schools rural areas Jiangsu Province. Based on a survey 606 from three township-level northern Jiangsu, findings revealed several key insights into students’ engagement, motivation, and strategies tutoring. Firstly, most voluntarily participated tutoring, primarily aiming to enhance their math performance. The overall behavior level was categorized as “high,”...
This study mainly aimed to determine the levels of students' participation in school-enterprise cooperation projects and their self-efficacy at a private university Shandong Province, China, explore relationship between these two variables. The surveyed total 303 senior students province through questionnaires. finally found that: 1) overall level was moderate, which proved that actual is not high needs be improved. 2) also moderate. 3) There strong positive correlation college...
To observe the clinical effects of acupuncture for diabetic peripheral neuropathy. Totally 65 patients were randomly divided into a treatment group 32 cases and control 33 cases. On basis conventional diabetes, was used in group, inositol orally administered group. During 3-month treatment, changes symptoms observed. In 16 markedly relieved, 12 improved, 4 failed, with total effective rate 87.5%. 7 14 improved 63.6%. There significant difference between 2 groups (P<0.05). Acupuncture may show good
Abstract To determine the preliminary effectiveness of breast cancer screening among Chinese females, 1226714 women aged 35–69 years first received clinical examinations. Urban with suspected mammography followed by ultrasound (BUS), while rural underwent BUS mammography. After one-year follow-up, 223 and 431 cancers were detected urban (respectively), overall detection rates 0.56/1000 0.52/1000. Higher significantly associated older age at for both women; additionally, higher risk if they...
This study aimed to explore the molecular mechanism and clinical relevance of iguratimod in regulation human B cell terminal differentiation. An vitro antibody-secreting (ASC) differentiation system was established test effect iguratimod. phenotype key transcription factors (TFs) relevant ASC were analyzed through flow cytometry qPCR. The COX-2 activity measured by enzyme immunoassay (EIA). RNA sequencing used identify potential targets We enrolled six treatment-naive rheumatoid arthritis...
Biochemical recurrence (BCR) occurs in up to 27% of patients after radical prostatectomy (RP) and often compromises oncologic survival. To determine whether imaging signatures on clinical prostate magnetic resonance (MRI) could noninvasively characterize biochemical optimize treatment. We retrospectively enrolled 485 underwent RP from 2010 2017 three institutions. Quantitative interpretable features were extracted T2 delineated tumors. Deep learning-based survival analysis was then applied...
The rapid development of computational pathology has brought new opportunities for prognosis prediction using histopathological images. However, the existing deep learning frameworks lack exploration relationship between images and other prognostic information, resulting in poor interpretability. Tumor mutation burden (TMB) is a promising biomarker predicting survival outcomes cancer patients, but its measurement costly. Its heterogeneity may be reflected Here, we report two-step framework...
The aims of this study were to isolate sesquiterpene compounds from the largehead atractylodes rhizome (LAR) and investigate their effects on B16 cancer cells. A total 8 sesquiterpenes LAR identified, which eudesm-4 (15), 7-diene-9α, 11-diol (7) was isolated for first time. All inhibited growth cells, atractylenolide I (AT-I), II (AT-II), atractylenolactam (ATR) most potent, with IC 50 values 76.46, 84.02, 54.88 μΜ, respectively. Monomer lactone or lactam structures in appeared be critical...