A5101933576- Virus-based gene therapy research
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- Synthesis and Catalytic Reactions
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Mycobacterium research and diagnosis
- Bioactive Compounds and Antitumor Agents
- Advanced Glycation End Products research
- Metabolism, Diabetes, and Cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Single-cell and spatial transcriptomics
- Biochemical effects in animals
- Plant Toxicity and Pharmacological Properties
- Cancer, Stress, Anesthesia, and Immune Response
- Synthesis of Indole Derivatives
- Traditional Chinese Medicine Analysis
- Synthesis and Biological Activity
- Ferroptosis and cancer prognosis
- Salivary Gland Disorders and Functions
- Ginseng Biological Effects and Applications
Zhejiang Lab
2024
Wenzhou Medical University
2024
Ghent University
2022-2024
The University of Texas Health Science Center at San Antonio
2021
Dalian Medical University
2021
First Affiliated Hospital of Dalian Medical University
2021
Binzhou People's Hospital
2019
Key Laboratory of Guangdong Province
2017-2018
South China University of Technology
2017-2018
Beijing Proteome Research Center
2018
Bladder cancer has become the most common malignant urinary carcinoma. Studies have shown that significant antioxidant and bladder cancer-fighting properties of several plant-based diets like Psidium guajava, ginger amomum, are associated with their high kaempferol content. In this paper, we evaluated anticancer activities its mechanism induction to apoptosis on cells. Our findings demonstrated showed an obvious radical scavenging activity in erythrocytes damaged by oxygen. Kaempferol...
Loss of phosphatase and tensin homolog (PTEN) represents one hallmark prostate cancer (PCa). However, restoration PTEN or inhibition the activated PI3K/AKT pathway has shown limited success, prompting us to identify obligate targets for disease intervention. We hypothesized that loss might expose cells unique epigenetic vulnerabilities. Here, we identified a synthetic lethal relationship between Brahma-related gene 1 (BRG1), an ATPase subunit SWI/SNF chromatin remodeling complex. Higher BRG1...
AbstractAutophagy-associated release of HMGB1 is known to protect cancer cells from many chemotherapeutics. However, the detailed molecular mechanism(s) responsible remains largely undefined. We show in this study that released into extracellular space protects gastric apoptosis induced by microtubule-targeting drug vincristine through transcriptional upregulation Mcl-1. Extracellular appeared essential for autophagy-mediated inhibition apoptosis, siRNA knockdown or its abolished protective...
Our findings provide comprehensive evidence that isoquercitrin (ISO) influenced T24 bladder cancer cell metabolism by activating the AMPK pathway as identified combination with metabolomics and immunoblotting assay.
ABSTRACT Dietary restriction (DR) is a well‐established method for extending lifespan across various species, including C. elegans . Among the different DR regimens, axenic dietary (ADR), in which worms are grown nutrient‐rich sterile liquid medium, yields most powerful extension. However, molecular mechanisms underlying this longevity phenotype remain largely unexplored. Through pilot screen of candidate genes, we identified proprotein convertase BLI‐4 as crucial factor neurons modulating...
Transferring therapeutic genes into the nociceptive system, including dorsal root ganglia (DRGs) and spinal cord, is potentially a powerful approach for treatment of chronic pain in humans. Adeno-associated viral vectors (AAVs) are particularly useful delivering foreign to targeted tissues because they seldom induce immune responses or produce cytotoxicity. To determine efficiency transgene expression best route(s) delivery, recombinant AAV type 2 vector containing enhanced green fluorescent...
Abstract In recent years, more and studies focus on the roles of genes or miRNAs in stroke. However, molecular mechanism connecting their targetgenes remains unclear. The aim this study was to determine differential regulation correlations between human Stroke-related were obtained from Human MicroRNA Disease Database (HMDD) generated three independent sources. Kappa score used create network functional modules. A total 11 stroke-related identified HMDD 441 overlapping extracted databases....
Two new monoterpenoid indole alkaloid derivatives, turpiniside (1) and 11-methoxyjavaniside (2), along with the known alkaloids, vincosamide (3), (3R)-pumiloside (4), paratunamide C (5), were isolated from leaves of Turpinia arguta (Lindl.) Seem. Their structures determined on basis spectroscopic data. Compounds 1 3–5 found to effect relaxation supercoiled pBR322 plasmid DNA in presence Cu2+.
Multiple-walled carbon nanotubes (MWCNTs) may cause carcinogenesis. We found that long-term exposure to MWCNTs can induce irreversible oncogenic transformation of human bronchial epithelial cells and tumorigenicity in vivo. A genome-wide array-comparative genomic hybridization (aCGH) analysis revealed global chromosomal aberration MWCNTs-treated clones, predominantly at chromosome 2q31–32, where the potential oncogenes HOXD9 HOXD13 are located. Functional assays confirmed this variation...
The merits of N-unsubstituted indoles and cyclopent[b]indoles as DNA-directed reductive alkylating agents are described. These systems represent a departure from N-substituted pyrrolo[1, 2-a]-fused such the mitomycins mitosenes. cyclopent[b]indole-based aziridinylquinone system, when bearing an acetate leaving group with or without N-acetyl group, was cytotoxic displayed significant in vivo activity against syngeneic tumor implants. analogues were superior to others studied terms both high...
Abstract We investigated the rosiglitazone (RSG) effect on adriamycin (ADM)‐induced cardio toxicity in experimental animals. Forty adult Wistar male rats were separated into four groups as follows: normal control; RSG (10 mg/kg)‐treated; ADM mg/kg)‐administered; and mg/kg) + mg/kg)‐treated. Serum lipid level, different biochemical biomarkers, histological analysis, nuclear factor erythroid 2‐related factor/heme oxygenase‐1 (Nrf2/HO‐1), Caspase 3, B‐cell lymphoma 2 (Bcl‐2), Bax gene...
Axenically cultured
Abstract Axenic dietary restriction (ADR) is highly effective in extending lifespan of Caenorhabditis elegans, but its effects on healthspan improvement are less well characterized. Using transmission electron microscopy, morphometric analyses, and functional assays, we found ADR can preserve tissue ultrastructure, including the cuticle, epidermis, intestinal lumen, reduce age-associated pathologies like gonad degeneration, uterine tumor clusters, pharyngeal deterioration, atrophy. However,...