A5045809285- Atmospheric chemistry and aerosols
- Atmospheric aerosols and clouds
- Autophagy in Disease and Therapy
- Atmospheric Ozone and Climate
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Air Quality and Health Impacts
- Ubiquitin and proteasome pathways
- SARS-CoV-2 and COVID-19 Research
- Nanoplatforms for cancer theranostics
- Cancer-related gene regulation
- Microbial Natural Products and Biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Microbial Metabolic Engineering and Bioproduction
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Endometriosis Research and Treatment
- interferon and immune responses
- Peptidase Inhibition and Analysis
- Enzyme Catalysis and Immobilization
- RNA and protein synthesis mechanisms
- Ion channel regulation and function
- Genomics and Phylogenetic Studies
- Enzyme Structure and Function
- Monoclonal and Polyclonal Antibodies Research
Singleron Biotechnologies (china)
2024-2025
People's Hospital of Xinjiang Uygur Autonomous Region
2024-2025
Protein Express (United States)
2023-2024
Shanghai Advanced Research Institute
2019-2024
Chinese Academy of Sciences
2015-2024
Chongqing Academy of Environmental Science
2022-2024
State Administration of Foreign Exchange
2024
Peking University
2009-2024
Center for Excellence in Molecular Cell Science
2015-2024
Shanghai Institutes for Biological Sciences
2015-2024
Protein post-translational modifications (PTMs) at the lysine residue, such as methylation, acetylation, and ubiquitination, are diverse, abundant, dynamic. They play a key role in regulation of diverse cellular physiology. Here we report discovery new type PTM, malonylation (Kmal). Kmal was initially detected by mass spectrometry protein sequence-database searching. The modification comprehensively validated Western blot, tandem MS, high-performance liquid chromatography synthetic peptides,...
An emerging cavefish model, the cyprinid genus Sinocyclocheilus, is endemic to massive southwestern karst area adjacent Qinghai-Tibetan Plateau of China. In order understand whether orogeny influenced evolution these species, and how genomes change under isolation, especially in subterranean habitats, we performed whole-genome sequencing comparative analyses three species this genus, S. grahami, rhinocerous anshuiensis. These are surface-dwelling, semi-cave-dwelling cave-restricted,...
The precise and large-scale identification of intact glycopeptides is a critical step in glycoproteomics. Owing to the complexity glycosylation, current overall throughput, data quality accessibility glycopeptide lack behind those routine proteomic analyses. Here, we propose workflow for high-throughput N-glycopeptides at proteome scale using stepped-energy fragmentation dedicated search engine. pGlyco 2.0 conducts comprehensive control including false discovery rate evaluation all three...
Abstract The formation mechanism of aerosol sulfate during wintertime haze events in China is still largely unknown. As companions, SO 2 and transition metals are mainly emitted from coal combustion. Here, we argue that the metal-catalyzed oxidation on surfaces could be dominant pathway investigate this hypothesis by integrating chamber experiments, numerical simulations in-field observations. Our analysis shows contribution manganese-catalyzed approximately one to two orders magnitude...
Abstract Stat6 is known to drive macrophage M2 polarization. However, how polarization fine-tuned by poorly understood. Here, we find that Lys383 of acetylated the acetyltransferase CREB-binding protein (CBP) during activation suppress Mechanistically, Trim24, a CBP-associated E3 ligase, promotes acetylation catalyzing CBP ubiquitination at Lys119 facilitate recruitment Stat6. Loss Trim24 inhibits and thus in both mouse human macrophages, potentially compromising antitumor immune responses....
Abstract Over-application of nitrogen fertilizer in fields has had a negative impact on both environment and human health. Domesticated rice varieties with high use efficiency (NUE) reduce for sustainable agriculture. Here, we perform genome-wide association analysis diverse population displaying extreme nitrogen-related phenotypes over three successive years the field, identify an elite haplotype nitrate transporter OsNPF6.1 HapB that enhances uptake confers NUE by increasing yield under...
SUMMARY A new coronavirus (CoV) identified as COVID-19 virus is the etiological agent responsible for 2019-2020 viral pneumonia outbreak that commenced in Wuhan 1–4 . Currently there no targeted therapeutics and effective treatment options remain very limited. In order to rapidly discover lead compounds clinical use, we initiated a program of combined structure-assisted drug design, virtual screening high-throughput identify leads target main protease (M pro ). M key CoV enzyme, which plays...
Competing signal peptides hold the key When a pollen grain lands on receptive flower's pistil, complex dance leading to sexual reproduction begins. Liu et al. show some of early steps that help distinguish compatible from random piece dust. Normally, stigmatic gatekeeper, ANJEA–FERONIA receptor kinase complex, perceives signaling produced by stigma drive production reactive oxygen species at papillae. Upon pollination, POLLEN COAT PROTEIN B-class compete with those for binding complex. The...
Stimulation of adipose tissue thermogenesis is regarded as a promising avenue in the treatment obesity. However, pharmacologic engagement this process has proven difficult. Using Connectivity Map (CMap) approach, we identified phytochemical hyperforin (HPF) an anti-obesity agent. We found that HPF efficiently promoted by stimulating AMPK and PGC-1α via Ucp1-dependent pathway. LiP-SMap (limited proteolysis-mass spectrometry) combined with microscale thermophoresis assay molecular docking...
Abstract A new coronavirus (SARS-CoV-2) has been identified as the etiologic agent for COVID-19 outbreak. Currently, effective treatment options remain very limited this disease; therefore, there is an urgent need to identify anti-COVID-19 agents. In study, we screened over 6,000 compounds that included approved drugs, drug candidates in clinical trials, and pharmacologically active leads target SARS-CoV-2 papain-like protease (PLpro). Together with main (M pro ), PLpro responsible...
Widespread lysine β-hydroxybutyrylation plays diverse regulatory roles and is reversibly regulated by p300 HDAC1/2.
Ferroptosis, an iron-dependent nonapoptotic cell death, is a highly regulated tumor suppressing process. However, functions and mechanisms of RNA-binding proteins in regulation evasion ferroptosis during lung cancer progression are still largely unknown. Here, we report that the protein RBMS1 participates development via mediating evasion. Through shRNA-mediated systematic screen, discovered key regulator. Clinically, was elevated its high expression associated with reduced patient survival....