About
Contact & Profiles
A5013772239
Research Areas
- Histone Deacetylase Inhibitors Research
- Diet and metabolism studies
- Biochemical Acid Research Studies
- Chemical Synthesis and Analysis
- CRISPR and Genetic Engineering
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
University of Chicago
2021
Widespread lysine β-hydroxybutyrylation plays diverse regulatory roles and is reversibly regulated by p300 HDAC1/2.
10.1126/sciadv.abe2771
article
EN
cc-by-nc
Science Advances
2021-02-24
Histone lysine crotonylation is a posttranslational modification with demonstrated functions in transcriptional regulation. Here we report the discovery of new type histone modification, methacrylation (Kmea), corresponding to structural isomer crotonyllysine. We validate identity this using diverse chemical approaches and further confirm occurrence mark by pan specific site-specific anti-methacryllysine antibodies. In total, identify 27 Kmea modified sites HeLa cells affinity enrichment...
10.1038/s41421-021-00344-4
article
EN
cc-by
Cell Discovery
2021-12-28
10.6082/uchicago.2232
article
EN
2020-01-01
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