A5013539817- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Ferroelectric and Piezoelectric Materials
- Antibiotic Resistance in Bacteria
- Genetic Neurodegenerative Diseases
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Phosphodiesterase function and regulation
- Multiferroics and related materials
- Animal Genetics and Reproduction
- Vibrio bacteria research studies
- Mitochondrial Function and Pathology
- Advanced Vision and Imaging
- Genetics, Aging, and Longevity in Model Organisms
- RNA and protein synthesis mechanisms
- Robotics and Sensor-Based Localization
- Electronic and Structural Properties of Oxides
- Chemical synthesis and alkaloids
- Circular RNAs in diseases
Sichuan University
2020-2025
West China Hospital of Sichuan University
2023-2025
Zhejiang University
2023-2025
Brown University
2024-2025
Xi'an Jiaotong University
2017-2024
Brigham and Women's Hospital
2022-2024
Harvard University
2022-2024
Augusta University
2023-2024
Shanghai Institute of Nutrition and Health
2020-2024
Center for Excellence in Molecular Cell Science
2020-2024
Abstract The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a suite database resources to support worldwide research activities in both academia and industry. With explosive growth multi-omics data, CNCB-NGDC is continually expanding, updating enriching its core through big data deposition, integration translation. In past year, considerable efforts have been devoted 2019nCoVR, newly established resource providing global landscape SARS-CoV-2...
Ferroptosis, an iron-dependent nonapoptotic cell death, is a highly regulated tumor suppressing process. However, functions and mechanisms of RNA-binding proteins in regulation evasion ferroptosis during lung cancer progression are still largely unknown. Here, we report that the protein RBMS1 participates development via mediating evasion. Through shRNA-mediated systematic screen, discovered key regulator. Clinically, was elevated its high expression associated with reduced patient survival....
Metabolic reprogramming shapes tumor microenvironment (TME) and may lead to immunotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). Elucidating the impact of cancer cell metabolism TME is essential therapeutic interventions. "Immune cold" PDAC characterized by elevated lactate levels resulting from metabolism, abundance pro-tumor macrophages, reduced cytotoxic T TME. Analysis 18F-FDG uptake patients showed that increased global protein lactylation correlates with worse clinical...
Abstract TransCirc (https://www.biosino.org/transcirc/) is a specialized database that provide comprehensive evidences supporting the translation potential of circular RNAs (circRNAs). This was generated by integrating various direct and indirect to predict coding each human circRNA putative products. Seven types for were included: (i) ribosome/polysome binding occupancy ribosomes onto circRNAs; (ii) experimentally mapped initiation sites on (iii) internal ribosome entry site (iv) published...
The centrosome provides an intracellular anchor for the cytoskeleton, regulating cell division, migration, and cilia formation. We used spatial proteomics to elucidate protein interaction networks at of human induced pluripotent stem cell-derived neural cells (NSCs) neurons. Centrosome-associated proteins were largely type-specific, with hubs involved in RNA dynamics. Analysis neurodevelopmental disease cohorts identified a significant overrepresentation NSC variants patients periventricular...
Calcium nanoparticles have been investigated for applications, such as drug and gene delivery. Additionally, Ca2+ serves a crucial second messenger in the activation of immune cells. However, few studies systematically studied effects calcium on levels functions within In this study, we explore potential vehicle to deliver into cytosol dendritic cells (DCs) influence their functions. We synthesized hydroxide nanoparticles, coated them with layer silica prevent rapid degradation, further...
Partial reprogramming by cyclic short-term expression of Yamanaka factors holds promise for shifting cells to younger states and consequently delaying the onset many diseases aging. However, delivery transgenes potential risk teratoma formation present challenges in vivo applications. Recent advances include use cocktails compounds reprogram somatic cells, but characteristics mechanisms partial cellular chemicals remain unclear. Here, we report a multi-omics characterization chemical...
Abstract In lung adenocarcinoma (LUAD), loss-of-function mutations in the splicing factor RBM10 frequently co-occur with oncogenic EGFR mutations. A detailed understanding of functional consequences and therapeutic impact loss EGFR-mutant LUAD could help identify more effective treatment strategies. Here, analysis data sets indicated that are mutually exclusive tumor suppressor gene TP53. an EGFR-driven mouse model, lung-specific ablation either Rbm10 or Trp53 similarly promoted development,...
RNA splicing defects are emerging molecular hallmarks of cancer. The gene encoding factor binding motif protein 10 (RBM10) has been found frequently mutated in various types cancer, particularly lung adenocarcinoma (LUAD), but how RBM10 affects cancer pathogenesis remains to be determined. Moreover, the functional roles and clinical significance mutation-associated events LUAD largely unknown.RBM10 mutations their impacts were examined patients from a Chinese patient cohort Cancer Genome...
Acinetobacter baumannii is an important pathogen in clinical. The factors of biofilm formation, antibiotic resistance and motility contribute great to A. persisting stressed environment, further leads nosocomial infections. 70 clinical isolates were investigated for their characteristics infection. Among the tested strains, 54 (77.1%) obtained from ICUs, with frequency multidrug-resistance (MDR) at 55.7%, that extensively drug-resistance (XDR) 31.4%. 97.1% could form biofilms, which 4.3%...
HfO 2 -based ferroelectrics have evoked considerable interest owing to the complementary metal–oxide semiconductor compatibility and robust ferroelectricity down a few unit cells. However, unique wake-up effect of ferroelectric films severely restricts improvement their performance. In particular, domain structure is an important characteristic materials, which still has not been well understood in ferroelectrics. this work, Hf 0.5 Zr O thin film grown on typical Si substrate buffered with...
KRAS mutations are causally linked to protumor inflammation and identified as driving factors in tumorigenesis. Here, using multiomics data gathered from a large set of patients, we showed that mutation was associated with specific landscape alternative mRNA splicing connected myeloid intrahepatic cholangiocarcinoma (iCCA). Then, negative feedback mechanism which the upregulation interleukin 1 receptor antagonist (IL1RN)-201/203 due confers vital anti-inflammatory effects KRAS-mutant iCCA....
Acinetobacter baumannii is a critical biofilm-forming pathogen that has presented great challenges in the clinic due to multidrug resistance. Thus, new methods of intervention are needed control biofilm-associated infections. In this study, among three tested Lactobacillus species, rhamnosus showed significant antimaturation and antiadherence effects against A. biofilm. Lactic acid (LA) acetic (AA) were most effective antibiofilm biosurfactants (BSs) produced by L. rhamnosus. This phenomenon...
Ferroelectricity is generally deteriorated or even vanishes when the ferroelectric films are downsized to unit cell scale. To maintain and enhance polarization in nanoscale ferroelectrics of scientific technological importance. Here, giant sustainability reported a series ultrathin PbTiO3 scaled down three cells grown on NdGaO3 (110) substrates with La0.7 Sr0.3 MnO3 as bottom electrodes. Atomic mappings via aberration-corrected scanning transmission electron microscopy demonstrate robust...
Gas disaster is one of the most serious disasters in coal mine safety production. Therefore, it great significance to strengthen gas forecasting warning technology research for improving ability prevention and control promoting development digital our country. The biggest characteristics using grey prediction model GM (1,1) that algorithm quite simple, also, when building model, less data can be used. It convenient modelling operation, but effect forecast systems with volatility not very...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and devastating lung disease lacking effective therapy. To identify whether phosphodiesterase-1 (PDE1) inhibition could act as novel target for the treatment of IPF, hit-to-lead structural optimizations were performed on PDE9/PDE1 dual inhibitor (R)-C33, leading to compound 3m with an IC50 2.9 nM against PDE1C, excellent selectivity across PDE subfamilies, reasonable drug-like properties, remarkable pharmacodynamic effects...
The type VI secretion system (T6SS) is a crucial virulence factor in the nosocomial pathogen Acinetobacter baumannii. However, its association with drug resistance less well known. Notably, roles that different T6SS components play process of antimicrobial resistance, as virulence, have not been systematically revealed. importance three representative core genes involved and A. baumannii, namely, tssB, tssD (hcp), tssM was elucidated. A higher ratio detected drug-resistant strains than...