Mochen Zhang
A5080950512- Genomics and Phylogenetic Studies
- Single-cell and spatial transcriptomics
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- SARS-CoV-2 detection and testing
- Plant Virus Research Studies
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- RNA Research and Splicing
- Biosensors and Analytical Detection
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Genetic Syndromes and Imprinting
- Cancer-related molecular mechanisms research
- Microbial Community Ecology and Physiology
Beijing Institute of Genomics
2020-2024
Chinese Academy of Sciences
2020-2024
University of Chinese Academy of Sciences
2020-2024
Shanghai Center For Bioinformation Technology
2020-2023
Baylor College of Medicine
2023
The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a family database resources to support global academic and industrial communities. With explosive accumulation multi-omics data generated at an unprecedented rate, CNCB-NGDC constantly expands updates core by big archive, integrative analysis value-added curation. In past year, efforts have been devoted integrating multiple omics data, synthesizing growing knowledge, developing new upgrading set...
Abstract The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a suite database resources to support worldwide research activities in both academia and industry. With explosive growth multi-omics data, CNCB-NGDC is continually expanding, updating enriching its core through big data deposition, integration translation. In past year, considerable efforts have been devoted 2019nCoVR, newly established resource providing global landscape SARS-CoV-2...
Abstract On January 22, 2020, China National Center for Bioinformation (CNCB) released the 2019 Novel Coronavirus Resource (2019nCoVR), an open-access information resource severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2019nCoVR features a comprehensive integration of sequence and clinical all publicly available SARS-CoV-2 isolates, which are manually curated with value-added annotations quality evaluated by automated in-house pipeline. Of particular note, offers systematic...
Alternative splicing (AS) is a fundamental process that governs almost all aspects of cellular functions, and dysregulation in this has been implicated tumor initiation, progression treatment resistance. With accumulating studies carcinogenic mis-splicing cancers, there an urgent demand to integrate cancer-associated changes better understand their internal cross-talks functional consequences from global view. However, resource key AS events human cancers still lacking. To fill the gap, we...
Single-cell bisulfite sequencing methods are widely used to assess epigenomic heterogeneity in cell states. Over the past few years, large amounts of data have been generated and facilitated deeper understanding epigenetic regulation many key biological processes including early embryonic development, differentiation tumor progression. It is an urgent need build a functional resource platform with massive amount data. Here, we present scMethBank, first open access comprehensive database...
Genomic epidemiology is important to study the COVID-19 pandemic, and more than two million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic sequences were deposited into public databases. However, exponential increase of invokes unprecedented bioinformatic challenges. Here, we present Coronavirus GenBrowser (CGB) based on a highly efficient analysis framework node-picking rendering strategy. In total, 1,002,739 high-quality with transmission-related metadata analyzed...
Abstract DNA methylation, as the most intensively studied epigenetic mark, regulates gene expression in numerous biological processes including development, aging, and disease. With rapid accumulation of whole-genome bisulfite sequencing data, integrating, archiving, analyzing, visualizing those data becomes critical. Since its first publication 2015, MethBank has been continuously updated to include more methylomes across diverse species. Here, we present 4.0...
Abstract On 22 January 2020, the National Genomics Data Center (NGDC), part of China for Bioinformation (CNCB), created 2019 Novel Coronavirus Resource (2019nCoVR), an open-access SARS-CoV-2 information resource. 2019nCoVR features a comprehensive integration sequence and clinical all publicly available isolates, which are manually curated with value-added annotations quality evaluated by our in-house automated pipeline. Of particular note, performs systematic analyses to generate dynamic...
Abstract The exponential growth of viral genome sequences in public databases has created a pressing need for universal, scalable, and automated taxonomic framework to facilitate comprehensive virus studies. Here, we present VISTA (Virus Sequence-based Taxonomy Assignment), novel computational tool taxonomy featuring pairwise sequence comparison system an automatic demarcation threshold identification framework. leverages physio-chemical property sequences, k-mer profiles selected features...
Abstract Genomic epidemiology is important to study the COVID-19 pandemic and more than two million SARS-CoV-2 genomic sequences were deposited into public databases. However, exponential increase of invokes unprecedented bioinformatic challenges. Here, we present Coronavirus GenBrowser (CGB) based on a highly efficient analysis framework movie maker strategy. In total, 1,002,739 high quality with transmission-related metadata analyzed visualized. The size core data file only 12.20 MB, for...
The rapid expansion of the number viral genome sequences in public databases necessitates a scalable, universal, and automated preliminary taxonomic framework for comprehensive virus studies. Here, we introduce VISTA (Virus Sequence-based Taxonomy Assignment), computational tool that employs novel pairwise sequence comparison system an automatic demarcation threshold identification taxonomy. Leveraging physio-chemical property sequences, k-mer profiles, machine learning techniques,...