Dongmei Tian
A5033900548- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic diversity and population structure
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Single-cell and spatial transcriptomics
- Extracellular vesicles in disease
- Soybean genetics and cultivation
- Bioenergy crop production and management
- Molecular Biology Techniques and Applications
- Reproductive Biology and Fertility
- Genetic and phenotypic traits in livestock
- Identification and Quantification in Food
- Animal Virus Infections Studies
- Endometriosis Research and Treatment
- Tryptophan and brain disorders
- Nematode management and characterization studies
- SARS-CoV-2 detection and testing
Beijing Institute of Genomics
2016-2025
Chengdu University of Traditional Chinese Medicine
2019-2025
First Affiliated Hospital of Anhui Medical University
2023-2025
Anhui Medical University
2023-2025
Ningbo University
2019-2024
Ningxia University
2024
University of Chinese Academy of Sciences
2011-2023
Chinese Academy of Sciences
2012-2023
Shanghai Center For Bioinformation Technology
2020-2023
Changzhou University
2019-2023
The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a family database resources to support global academic and industrial communities. With explosive accumulation multi-omics data generated at an unprecedented rate, CNCB-NGDC constantly expands updates core by big archive, integrative analysis value-added curation. In past year, efforts have been devoted integrating multiple omics data, synthesizing growing knowledge, developing new upgrading set...
The National Genomics Data Center (NGDC) provides a suite of database resources to support worldwide research activities in both academia and industry. With the rapid advancements higher-throughput lower-cost sequencing technologies accordingly huge volume multi-omics data generated at exponential scales rates, NGDC is continually expanding, updating enriching its core through big integration value-added curation. In past year, efforts for update have been mainly devoted BioProject,...
Abstract The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a suite database resources to support worldwide research activities in both academia and industry. With explosive growth multi-omics data, CNCB-NGDC is continually expanding, updating enriching its core through big data deposition, integration translation. In past year, considerable efforts have been devoted 2019nCoVR, newly established resource providing global landscape SARS-CoV-2...
GWAS Atlas (https://bigd.big.ac.cn/gwas/) is a manually curated resource of genome-wide variant-trait associations for wide range species. Unlike existing related resources, it features comprehensive integration high-quality collection 75 467 614 traits across 7 cultivated plants (cotton, Japanese apricot, maize, rapeseed, rice, sorghum and soybean) two domesticated animals (goat pig), which were from 254 publications. We integrated these into presented them in terms variants, genes, traits,...
Hybrid rice is the dominant form of planted in China, and its use has extended worldwide since 1970s. It offers great yield advantages contributed greatly to world's food security. However, molecular mechanisms underlying heterosis have remained a mystery. In this study we integrated genetics omics analyses determine candidate genes for model two-line hybrid system, Liang-you-pei 9 (LYP9) parents. Phenomics revealed that better parent (BPH) not ascribed BPH all components but specific...
The BIG Data Center at Beijing Institute of Genomics (BIG) the Chinese Academy Sciences provides a suite database resources in support worldwide research activities both academia and industry. With vast amounts multi-omics data generated unprecedented scales rates, is continually expanding, updating enriching its core through big integration value-added curation. Resources with significant updates past year include BioProject (a biological project library), BioSample sample Genome Sequence...
Abstract The BIG Data Center at Beijing Institute of Genomics (BIG) the Chinese Academy Sciences provides freely open access to a suite database resources in support worldwide research activities both academia and industry. With vast amounts omics data generated ever-greater scales rates, is continually expanding, updating enriching its core through big-data integration value-added curation, including BioCode (a repository archiving bioinformatics tool codes), BioProject biological project...
Abstract On January 22, 2020, China National Center for Bioinformation (CNCB) released the 2019 Novel Coronavirus Resource (2019nCoVR), an open-access information resource severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2019nCoVR features a comprehensive integration of sequence and clinical all publicly available SARS-CoV-2 isolates, which are manually curated with value-added annotations quality evaluated by automated in-house pipeline. Of particular note, offers systematic...
During mouse antral follicle development, the oocyte chromatin gradually transforms from a less condensed state with no Hoechst-positive rim surrounding nucleolus (NSN) to fully (SN). Compared SN oocytes, NSN oocytes display higher gene transcription activity and lower rate of meiosis resumption (G2/M transition), they are mostly arrested at two-cell stage after in vitro fertilization. To explore differences between maternal factors required for developmental competence, we compared...
Abstract The Genome Variation Map (GVM; http://bigd.big.ac.cn/gvm/) is a public data repository of genome variations. It aims to collect and integrate variations for wide range species, accepts submissions different variation types from all over the world provides free open access publicly available in support worldwide research activities. Compared with previous version, particularly, total 22 115 projects, 55 935 samples, 463 429 609 variants, 66 220 associations 56 (as 7 September 2020)...
GWAS Atlas (https://ngdc.cncb.ac.cn/gwas/) is a manually curated resource of genome-wide genotype-to-phenotype associations for wide range species. Here, we present an updated implementation by curating and incorporating more high-quality associations, with significant improvements advances over the previous version. Specifically, current release incorporates total 278,109 1,444 different traits across 15 species (10 plants 5 animals) from 830 publications 3,432 studies. A collection 6,084...
The Genome Variation Map (GVM; http://bigd.big.ac.cn/gvm/) is a public data repository of genome variations. As core resource in the BIG Data Center, Beijing Institute Genomics, Chinese Academy Sciences, GVM dedicates to collect, integrate and visualize variations for wide range species, accepts submissions different types from all over world provides free open access publicly available support worldwide research activities. Unlike existing related databases, features integration large...
Abstract Summary: mRNA/miRNA-seq technology is becoming the leading to globally profile gene expression and elucidate transcriptional regulation mechanisms in living cells. Although there are many tools available for analyzing RNA-seq data, few of them as easy accessible online web processing both mRNA miRNA data based user community. As such, we have developed a comprehensive application tool mRNA-seq miRNA-seq data. Our wapRNA includes four different modules: sequenced from SOLiD or Solexa...
Seasonal estrus is a critical limiting factor of animal fecundity, and it involves changes in both ovarian biology hormone secretion different seasons. Previous studies indicate that two classes small RNAs (miRNAs piRNAs) play important regulatory roles biology. To understand the RNA-mediated post-transcriptional regulation ovine seasonal estrus, variation expression patterns during anestrus breeding season were analyzed using Solexa sequencing technology. In addition, reproductive levels...
As peripheral blood contains fluctuated levels of circulating cell-free mitochondrial DNA (ccf mtDNA), we aimed to evaluate ccf mtDNA as a biomarker for diagnosis and prognosis epithelial ovarian cancer (EOC). In the present study, recruited 165 EOC patients 60 healthy women. Quantitative RT-PCR was applied amplify 79-bp 230-bp fragments 16 s RNA gene in sera these participants. MtDNA integrity defined ratio long short fragments. We observed that mtDNA79 mtDNA230 were significantly increased...
Soybean is one of the most important crops in world and its production needs to be significantly increased meet escalating global demand. Elucidating genetic regulatory networks underlying soybean organ development critical for breeding elite resilient varieties ensure an increase under changing climates. Integrated transcriptomic atlas that leverages multiple types data can facilitate characterization temporal-spatial expression patterns development-related genes thereby help understand...