A5009083833- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Genetics and Neurodevelopmental Disorders
- Dietary Effects on Health
- Health, Environment, Cognitive Aging
- Titanium Alloys Microstructure and Properties
- Tissue Engineering and Regenerative Medicine
- Metallurgy and Material Forming
- Genomics and Chromatin Dynamics
- COVID-19 Clinical Research Studies
- Birth, Development, and Health
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Intermetallics and Advanced Alloy Properties
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
- Soybean genetics and cultivation
- Long-Term Effects of COVID-19
- Advanced Proteomics Techniques and Applications
- Tea Polyphenols and Effects
- Advanced Materials and Mechanics
- Histone Deacetylase Inhibitors Research
Brigham and Women's Hospital
2018-2025
Harvard University
2018-2025
Nanjing Tech University
2023-2025
Beijing Graphene Institute
2025
Guangxi Normal University
2025
China Medical University
2024
Sheng Jing Hospital
2024
Shanghai Jiao Tong University
2023
University of Cambridge
2016
Tsinghua University
2015
COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 coronavirus that poses one of greatest challenges to public health in recent years. known preferentially target older subjects and those with pre-existing conditions, but reason for this age dependence unclear. Here, we found case fatality rate grows exponentially all countries tested, doubling time approaching all-cause human mortality. In addition, men multiple age-related diseases are characterized increased Moreover, similar...
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging.
Abstract The naked mole-rat (NMR) is an exceptionally long-lived rodent that shows no increase of mortality with age, defining it as a demographically non-aging mammal. Here, we perform bisulfite sequencing the blood > 100 NMRs, assessing 3 million common CpG sites. Unsupervised clustering based on sites whose methylation correlates age reveals age-related methylome remodeling, and also observe information loss, suggesting NMRs age. We develop epigenetic aging clock accurately predicts...
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in field. While highlighting some common features aging, exposed broad disagreement on foundational issues. What is aging? causes it? When does it begin? constitutes rejuvenation? Not only was there no consensus these and other core questions, but none questions received majority opinion-even regarding need for itself. Despite many believing understand their understanding...
SUMMARY Health is strongly affected by aging and lifespan-modulating interventions, but the molecular mechanisms of mortality regulation remain unclear. Here, we conducted an RNA-seq analysis mice subjected to 20 compound treatments in Interventions Testing Program (ITP). By integrating it with data from over 4,000 rodent tissues representing responses genetic, pharmacological, dietary interventions established survival data, developed robust multi-tissue transcriptomic biomarkers mortality,...
Abstract COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 coronavirus that poses one of greatest challenges to public health in recent years. highly contagious and often leads severe viral pneumonia with respiratory failure death elderly subjects pre-existing conditions, but reason for this age dependence unclear. Here, we found case fatality rate grows exponentially Italy, Spain, South Korea, China, doubling time approaching all-cause human mortality. In addition, men those multiple...
In this study, we investigated the two-stage deformation behavior of near α Ti-6.5Al–2Zr–1Mo–1V alloy at various temperatures (915 °C, 950 1020 °C) and strain rates (0.01 s−1, 0.1 s−1). The underwent differing holding periods (500s, 1000s) between stages. results demonstrated an increase in flow stress with decreasing temperature increasing rate. Work hardening was observed during thermomechanical processing within α+β two-phase region. Microstructural evolution characterized by formation...
A method for screening compatible buffer conditions both DNA origami and protein crystallisation studied how notably cations, buffering agents, precipitants, pH, influenced the stability of tubular origami.
Abstract The aging process is universal, and it characterized by a progressive deterioration decrease in physiological function leading to decline on the organismal level. Nevertheless, number of genetic non-genetic interventions have been described, which successfully extend healthspan lifespan different species. Furthermore, clinical trials evaluating feasibility promote human health. goal annual Biological Sciences Section Gerontological Society America meeting was share current knowledge...
Soybean is one of the most important crops in world and its production needs to be significantly increased meet escalating global demand. Elucidating genetic regulatory networks underlying soybean organ development critical for breeding elite resilient varieties ensure an increase under changing climates. Integrated transcriptomic atlas that leverages multiple types data can facilitate characterization temporal-spatial expression patterns development-related genes thereby help understand...
Abstract Age-related changes in DNA methylation (DNAm) form the basis for development of most robust predictors age, epigenetic clocks, but a clear mechanistic exactly what part aging process they quantify is lacking. Here, to clarify nature aging, we juxtapose dynamics tissue and single-cell DNAm (scDNAm) with scDNAm during early development, corroborate our analyses RNAseq analysis within same multi-omics dataset. We show that involves co-regulated changes, it dominated by stochastic...
This study investigates the effect of ω phase on microstructure evolution and mechanical properties Ti–3Al–5Mo–4Cr–2Zr–1Fe (Ti-35421) near β titanium alloy. The employed a solution treatment at 850 °C followed by two aging treatments, namely, Double Aging (DA) Isothermal Annealing (IA). results show that DA alloy had finer precipitation fewer Precipitation-Free Zones (PFZs) than IA While Ultimate Tensile Strength (UTS) was higher (1376 MPa) (1272 MPa), its plasticity lower. On other hand,...
Aging involves coordinated yet distinct changes in organs and systems throughout life, including essential trace elements. However, how aging affects tissue element composition (ionome) these lead to dysfunction disease remain unclear. Here, we quantified the ionome across eight 16 age groups of mice. This global profiling revealed novel interactions between elements at level tissue, age, diet, allowed us achieve a broader, organismal view process. We found that while entire steadily...
Advanced age is associated with accumulation of damage and other deleterious changes a consequential systemic decline function. This affects all organs systems in an organism, leading to their inadaptability the environment, therefore thought be inevitable for humans most animal species. However, vitro vivo application reprogramming strategies, which convert somatic cells induced pluripotent stem cells, has demonstrated that aged can rejuvenated. Moreover, data theoretical considerations...
Abstract Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss function, leading to increases in morbidity mortality. However, recent vitro studies have raised the possibility age reversal. Here, we report that biological fluid exhibits rapid changes both directions. By applying advanced epigenetic aging clocks, find young mice increased by heterochronic parabiosis restored following surgical detachment animals. We also identify transient during...
Abstract Recent studies suggest the existence of a natural rejuvenation event during early embryonic development mice, followed by epigenetic aging. Here, profiling DNA methylation in African clawed frog, Xenopus laevis , we found that entropy basepoint maps to gastrulation stage embryogenesis and corresponds rapid increase embryo transcript abundance. We further developed frog aging clock, revealing this species epigenetically ages. Application clock developmental stages identified decrease...