COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 coronavirus that poses one of greatest challenges to public health in recent years. known preferentially target older subjects and those with pre-existing conditions, but reason for this age dependence unclear. Here, we found case fatality rate grows exponentially all countries tested, doubling time approaching all-cause human mortality. In addition, men multiple age-related diseases are characterized increased Moreover, similar...

Abstract Aging populations face diminishing quality of life due to increased disease and morbidity. These challenges call for longevity research focus on understanding the pathways controlling healthspan. We use data from UK Biobank (UKB) cohort observe that risks major chronic diseases exponentially double every eight years, i.e., at a rate compatible with Gompertz mortality law. Assuming aging drives acceleration in morbidity rates, we build risk model predict age end healthspan depending...

Abstract Age-related physiological changes in humans are linearly associated with age. Naturally, linear combinations of measures trained to estimate chronological age have recently emerged as a practical way quantify aging the form biological In this work, we used one-week long physical activity records from 2003–2006 National Health and Nutrition Examination Survey (NHANES) compare three increasingly accurate models: unsupervised Principal Components Analysis (PCA) score, multivariate...

We propose a new biomathematical method, OncoFinder, for both quantitative and qualitative analysis of the intracellular signaling pathway activation (SPA). This method is universal may be used any physiological, stress, malignancy other perturbed conditions at molecular level. In contrast to existing techniques aggregation generalization gene expression data individual samples, we suggest distinguish positive/activator negative/repressor role every product in each pathway. show that...

Abstract COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 coronavirus that poses one of greatest challenges to public health in recent years. highly contagious and often leads severe viral pneumonia with respiratory failure death elderly subjects pre-existing conditions, but reason for this age dependence unclear. Here, we found case fatality rate grows exponentially Italy, Spain, South Korea, China, doubling time approaching all-cause human mortality. In addition, men those multiple...

Heritability of human lifespan is 23-33% as evident from twin studies. Genome-wide association studies explored this question by linking particular alleles to traits. However, genetic variants identified so far can explain only a small fraction heritability in humans. Here, we report that the burden rarest protein-truncating (PTVs) two large cohorts negatively associated with healthspan and lifespan, accounting for 0.4 1.3 years their variability, respectively. In addition, longer-living...

The mounting challenge of preserving the quality life in an aging population directs focus longevity science to regulatory pathways controlling healthspan. To understand nature relationship between healthspan and lifespan uncover genetic architecture two phenotypes, we studied incidence major age-related diseases UK Biobank (UKB) cohort. We observed that rates chronic increase exponentially. risk disease acquisition doubled approximately every eight years, i.e., at a rate compatible with...

Although accumulation of molecular damage is suggested to be an important mechanism aging, a quantitative link between the dynamics and mortality species has so far remained elusive. To address this question, we examine stability properties generic gene regulatory network (GRN) demonstrate that many characteristics aging associated population rate emerge as inherent critical regulation metabolic levels. Based on analysis age-dependent changes in gene-expression profiles Drosophila...

Aim: To investigate the comparative effectiveness of trastuzumab emtansine (T-DM1) in a real-world population HER2+ metastatic breast cancer (mBC) patients. Materials & methods: The Flatiron Health database was used to identify cohort mBC patients who received first-line treatment and T-DM1 or lapatinib plus chemotherapy as second-line treatment. Overall survival compared between two groups. Results: A total 278 with 34 chemotherapy. longer treated than those (adjusted hazard ratio:...

Aging-related physiological changes are systemic and, at least in humans, linearly associated with age. Therefore, linear combinations of measures trained to estimate chronological age have recently emerged as a practical way quantify aging the form biological Aging acceleration, defined difference between predicted and was found be elevated patients major diseases is predictive mortality. In this work, we compare three increasingly accurate models: metrics derived from unsupervised...

Primary rhegmatogenous retinal detachment (RRD) is a severe, potentially disabling ophthalmic pathology that requires timely surgical treatment to prevent progressive loss of vision. Purpose. To analyze the incidence RRD in Udmurt Republic for three-year period and study an influence clinical sociodemographic factors occurrence studied pathology. Methods. Retrospective assessment 523 cases first time diagnosed primary from 2019 2021 was conducted. Data analysis performed on basis Republican...

In the presented work results of GRBs temporal profiles analysis in high energy gamma-band are discussed. Now gamma-emission was observed both during short and long bursts mostly by detectors onboard Fermi Agile satellites. The duration such emission is more than some hundreds seconds sufficiently longer t90 low band. But usually maximum intervals. However investigation region E>100 MeV have shown opportunity new burst type separation. difference usual GRBs, several characteristic features....

Most part of gamma-ray bursts (GRBs) spectra are well described by Band model with following parameters: α, β (spectral indices in low and high energy bands) Epeak (energy spectral peak). For several GRB parameter characterizing the shape region up to some hundred MeV (for example, GRB100724B). Moreover, spectrum GRB080916C covering 6 orders magnitude. Until recently hardness H32 (the ratio total counts 100 − 300 keV 50 range) was used for additional classification events on hard soft, GRBs...

Genome-wide association studies often explore links between particular genes and phenotypes of interest. Known genetic variants, however, are responsible for only a small fraction human lifespan variation evident from twin studies. To account the missing longevity variance, we hypothesized that cumulative effect deleterious variants may affect longevity. Here, report burden rarest protein-truncating (PTVs) negatively impacts both healthspan in two large independent cohorts. Longer-living...