A5082716768- Supramolecular Self-Assembly in Materials
- Polydiacetylene-based materials and applications
- Alzheimer's disease research and treatments
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Analysis
- Protein Structure and Dynamics
- Advanced biosensing and bioanalysis techniques
- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Luminescence and Fluorescent Materials
- Bacteriophages and microbial interactions
- Enzyme Structure and Function
- 2D Materials and Applications
- Crystallography and molecular interactions
- Supramolecular Chemistry and Complexes
- Advanced Sensor and Energy Harvesting Materials
- RNA Interference and Gene Delivery
- Computational Drug Discovery Methods
- Prion Diseases and Protein Misfolding
- Glycosylation and Glycoproteins Research
- Bacterial Genetics and Biotechnology
- Metabolomics and Mass Spectrometry Studies
- Amino Acid Enzymes and Metabolism
- Parkinson's Disease Mechanisms and Treatments
Tel Aviv University
2016-2025
Zhejiang Energy Research Institute
2024
Zhejiang University
2023-2024
Zhejiang Lab
2024
Xidian University
2022-2023
Weizmann Institute of Science
1993-2020
Umeå University
2020
Weatherford College
2020
Robert Bosch (Germany)
2020
University of California, Riverside
2020
Tubular nanostructures are suggested to have a wide range of applications in nanotechnology. We report our observation the self-assembly very short peptide, Alzheimer's β-amyloid diphenylalanine structural motif, into discrete and stiff nanotubes. Reduction ionic silver within nanotubes, followed by enzymatic degradation peptide backbone, resulted production nanowires with long persistence length. The same dipeptide building block, made D-phenylalanine, enzymatically stable
Amyloid fibril formation is assumed to be the molecular basis for a variety of diseases unrelated origin. Despite its fundamental clinical importance, mechanism amyloid not fully understood. When we analyzed short functional fragments from amyloid-forming proteins, remarkable occurrence aromatic residues was observed. The finding in diverse raises possibility that pi-pi interactions may play significant role recognition and self-assembly processes lead formation. This line with well-known...
A simple dipeptide self-assembles into a biocompatible hydrogel (see figure and inside cover). This novel biomaterial is extremely to prepare has remarkable rigidity. It very stable under extreme conditions, can be injected, shaped according the vessel it been assembled in. The allows wide variety of possible biomedical applications including tissue engineering, axonal regeneration, controlled drug release.
We recently demonstrated that the diphenylalanine recognition motif of Alzheimer's β-amyloid polypeptide self-assembles into ordered and discrete nanotubes. Here, we reveal diphenylglycine, a highly similar analogue simplest aromatic peptide, forms spherical nanometric assemblies. As nanotubes, nanospheres assemble efficiently have remarkable stability. The introduction thiol group peptide alters its assembly from tubular to particles those formed by diphenylglycine. formation either...
We show anomalously strong shear piezoelectric activity in self-assembled diphenylalanine peptide nanotubes (PNTs), indicating electric polarization directed along the tube axis. Comparison with well-known LiNbO3 and lateral signal calibration yields sufficiently high effective coefficient values of at least 60 pm/V (shear response for tubes ≈200 nm diameter). PNTs demonstrate linear deformation without irreversible degradation a broad range driving voltages. The results open up wide avenue...
The development of type II diabetes was shown to be associated with the formation amyloid fibrils consisted islet polypeptide (IAPP or amylin). Recently, a short functional hexapeptide fragment IAPP (NH2-NFGAIL-COOH) found form that are very similar those formed by full-length polypeptide. To better understand specific role residues compose fragment, we performed systematic alanine scan "basic amyloidogenic units." Turbidity assay experiments demonstrated wild-type peptide and Asn1 → Ala...
We recently presented a novel class of self-assembled diphenylalanine-based peptide nanotubes. Here, for the first time, we present their mechanical properties, which directly measured through indentation type experiments using atomic force microscopy. find that averaged point stiffness nanotubes is 160 N/m, and they have correspondingly high Young's modulus ∼19 GPa, as calculated by finite element analysis. This value places these among stiffest biological materials presently known, making...
The diphenylalanine peptide, the core recognition motif of β-amyloid polypeptide, efficiently self-assembles into discrete, well-ordered nanotubes. Here, we describe notable thermal and chemical stability these tubular structures both in aqueous solution under dry conditions. Scanning transmission electron microscopy (SEM TEM) as well atomic force (AFM) revealed nanotubes at temperatures above boiling point water upon autoclave treatment. preserved their secondary structure up to 90 °C,...
Abstract Peptide-based supramolecular assemblies are a promising class of nanomaterials with important biomedical applications, specifically in drug delivery and tissue regeneration. However, the intrinsic antibacterial capabilities these have been largely overlooked. The recent identification common characteristics shared by self-assembling peptides provides paradigm shift towards development agents. Here we present activity self-assembled diphenylalanine, which emerges as minimal model for...
Hydrogels are of great interest as a class materials for tissue engineering, axonal regeneration, and controlled drug delivery, they offer 3D interwoven scaffolds to support the growth cells. Herein, we extend family aromatic Fmoc-dipeptides with library new Fmoc-peptides, which include natural synthetic amino acids an nature. We describe self-assembly these Fmoc-peptides into various structures characterize their distinctive molecular physical properties. Moreover, fabrication bioactive RGD...