A5050039946- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
- Extracellular vesicles in disease
- SARS-CoV-2 and COVID-19 Research
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Insect-Plant Interactions and Control
- Forest Insect Ecology and Management
- Bacteriophages and microbial interactions
- Inflammasome and immune disorders
- Entomopathogenic Microorganisms in Pest Control
- Metabolomics and Mass Spectrometry Studies
- Insect and Pesticide Research
- Long-Term Effects of COVID-19
- Insect Pheromone Research and Control
- Kawasaki Disease and Coronary Complications
- SARS-CoV-2 detection and testing
- Insect and Arachnid Ecology and Behavior
- COVID-19 Clinical Research Studies
- Viral-associated cancers and disorders
- Neurobiology and Insect Physiology Research
- Adipose Tissue and Metabolism
Chinese Academy of Agricultural Sciences
2021-2024
Institute of Plant Protection
2021-2024
Shanghai Jiao Tong University
2020-2023
Ruijin Hospital
2022-2023
Shanghai Children's Hospital
2020-2021
Gansu Agricultural University
2021
Institute of Immunology
2020
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent for coronavirus disease 2019 (COVID-19) pandemic and there an urgent need to understand cellular response SARS-CoV-2 infection. Beclin 1 essential scaffold autophagy protein that forms two distinct subcomplexes with modulators Atg14 UVRAG, responsible autophagosome formation maturation, respectively. In present study, we found infection triggers incomplete response, elevated but impaired declined by genetic...
ABSTRACT The ongoing coronavirus disease (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a global public health concern due to relatively easy person-to-person transmission and the current lack of effective antiviral therapy. However, exact molecular mechanisms SARS-CoV-2 pathogenesis remain largely unknown. We exploited an integrated proteomics approach systematically investigate intra-viral virus-host interactomes for identification unrealized...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection leads to the accumulation of lipid droplets (LD), central hubs metabolism, in vitro or type II pneumocytes and monocytes from coronavirus disease 19 (COVID-19) patients blockage LD formation by specific inhibitors impedes SARS-CoV-2 replication. Here, we showed that ORF3a is necessary sufficient trigger during infection, leading efficient virus Although highly mutated evolution, ORF3a-mediated modulation conserved most...
Animals have endogenous clocks that regulate their behavior and physiology. These rely on environmental cues (time givers) appear approximately every 24 h due to the Earth's rotation; thus, most insects exhibit a circadian rhythm. One notable exception is scarab beetle, Holotrichia parallela, severe agricultural pest in China, Japan, South Korea, India. Females emerge from soil other night, reach canopy of host plants, evert an abdominal gland, release pheromone bouquet comprising...
ABSTRACT SARS-CoV-2 is the causative agent for COVID-19 pandemic and there an urgent need to understand cellular response infection. Beclin-1 essential scaffold autophagy protein that forms two distinct subcomplexes with modulators Atg14 UVRAG, responsible autophagosome formation maturation, respectively. In present study, we found infection triggers incomplete response, elevated but impaired declined by genetic knockout of autophagic genes reduces replication efficiency. By screening 28...
Holotrichia parallela is one of the agriculturally important scarab beetle pests in China. In this study, HparOBP14 was cloned, which most abundantly expressed among OBP genes legs female H. adults. Sequence comparison and phylogenetic analysis showed that has a Plus-C structure motif. The expression profile revealed highest antennae then legs. fluorescence competitive binding experiment recombinant protein had an affinity with 6-methyl-5-heptene-2-one (plant volatile), 3-methylindole,...
Abstract BACKGROUND The chafer beetle, Holotrichia parallela , causes damage to numerous economically significant crops worldwide. Adult beetles exhibit aggregation behavior likely mediated by a male‐produced pheromone. Advancements in biological research technology have facilitated the identification of insect pheromones and promoted their applications as bait for trapping monitoring pests. Currently, only few active components from species been identified. However, specific produced H....
Abstract SARS-CoV-2 is the causative agent for COVID-19 pandemic and there an urgent need to understand cellular response infection. Beclin-1 essential scaffold autophagy protein that forms two distinct subcomplexes with modulators Atg14 UVRAG, responsible autophagosome formation maturation, respectively. In present study, we found infection triggers incomplete response, elevated but impaired declined by genetic knockout of autophagic genes reduces replication efficiency. By screening 28...