A5067545760- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Educational Technology and Pedagogy
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Fungal and yeast genetics research
- Plant and Fungal Species Descriptions
- RNA Interference and Gene Delivery
- Cardiovascular Health and Risk Factors
- Educational Reforms and Innovations
- Ideological and Political Education
- Medical Research and Treatments
- Ferroptosis and cancer prognosis
- Enzyme Structure and Function
- Reproductive Biology and Fertility
- Innovative Educational Techniques
- Circular RNAs in diseases
- Genomics and Phylogenetic Studies
- Food composition and properties
- Healthcare Systems and Public Health
Xiangnan University
2021-2025
Jiangsu University of Science and Technology
2025
Changhai Hospital
2023-2024
Dalian Medical University
2021-2024
Second Affiliated Hospital of Dalian Medical University
2021-2024
University of North Carolina at Chapel Hill
2022-2024
Second Military Medical University
2023-2024
Yixing People's Hospital
2024
Jiangsu University
2024
Yichang Central People's Hospital
2021
Ferroptosis, an iron-dependent nonapoptotic cell death, is a highly regulated tumor suppressing process. However, functions and mechanisms of RNA-binding proteins in regulation evasion ferroptosis during lung cancer progression are still largely unknown. Here, we report that the protein RBMS1 participates development via mediating evasion. Through shRNA-mediated systematic screen, discovered key regulator. Clinically, was elevated its high expression associated with reduced patient survival....
Gluten-free rice bread made from japonica finds challenge in achieving a good shape and structure, presenting significant obstacle the baking industry. This study aims to improve quality of with flour by hot extrusion treatment (without additives). The effects on amylose content, gelatinization degree, hydration capacity, short-range molecular ordering, microstructure were investigated. results show that content extruded increased 12.43% degree it 13.23 times, showing disrupted starch...
Animal replication-dependent histone mRNAs end in a conserved stem loop (SL) instead of the canonical poly(A) tail present all other eukaryotic mRNAs. Degradation SL at S-phase is initiated by stem-loop binding protein SLBP and its interplay with RNA helicase UPF1 exoribonuclease 3′hExo. We report direct interactions between show that unstructured N-terminus wraps around core, contacting it multiple sites. Although to impedes unwinding activity, critical for efficient mRNA decay cells, as...
To explore the mechanism of Circ-MYOCD back-splicing and its regulatory role in myocardial hypertrophy. Sanger sequencing RNase R assays were performed to verify circularity stability Circ-MYOCD, whose subcellular distribution was determined by nuclear-cytoplasmic fractionation. Bioinformatics analysis mass spectrometry from pull-down conducted predict RNA-binding proteins (RBPs) interacting with Circ-MYOCD. In rat cardiomyocytes H9C2 cells, effects HNRNPH1 HNRNPL knockdown overexpression on...
Sexual maturation and somatic growth cessation are associated with adolescent development, which is precisely controlled by interconnected neuroendocrine regulatory pathways in the endogenous endocrine system. The pituitary gland one of key regulators By analyzing RNA sequencing (RNA-seq) transcriptome before after sexual maturation, this study, we characterized global gene expression patterns zebrafish pituitaries at 45 90 days post-fertilization (dpf). A total 15 043 annotated genes were...
Stem–loop binding protein (SLBP) is required for replication-dependent histone mRNA metabolism in mammals. Zebrafish possesses two slbps , and slbp1 necessary retinal neurogenesis. However, the detailed expression function of slbp2 zebrafish are still unknown. In this study, we first identified as an oocyte-specific maternal factor then generated a maternal-zygotic F3 homozygous mutant (MZ Δ4 −/− ) using CRISPR/Cas9. The depletion Slbp2 disrupted early nuclear cleavage, which resulted...
PRKAG2 is required for the maintenance of cellular energy balance. PRKAG2-AS1, a long non-coding RNA (lncRNA), was found within promoter region PRKAG2. Despite extensive expression PRKAG2-AS1 in endothelial cells, precise function and mechanism this gene cells have yet to be elucidated. The localization predominantly observed nucleus, as revealed using nuclear cytoplasmic fractionation fluorescence situ hybridization. manipulation by knockdown overexpression nucleus significantly altered
Cornus hongkongensis Hemsl. 1888, native to Hong Kong, belongs the subgenus Syncarpea within genus of Cornaceae family. The complete chloroplast genome C. spans 156,954 bp, comprising four subregions: a large single-copy region (86,290 bp), small (18,394 and pair inverted repeats (26,135 bp). Within hongkongensis, we identified 113 unique genes, including 80 protein-encoding ribosomal RNA (rRNA) 30 transfer (tRNA) genes. Phylogenetic analysis based on related taxa indicates that has not...
The purpose of this work is to investigate the function SNHG1, a long non-coding RNA implicated in disease progression, apoptosis, and proliferation, order solve problem hypoxic-ischemic encephalopathy (HIE) newborn care. We investigated impact overexpressing SNHG1 on hypoxia-induced apoptosis studied its expression BV2 microglial cells under hypoxic circumstances. As result modifying YY1 expression, SNHG1′s overexpression prevents as our data demonstrate that it considerably downregulated...
Abstract The role of PRKAG2 in the maintenance heart function is well established, but little known about how regulated cardiomyocytes. In this study, we investigated lncRNA PRKAG2-AS , which present at promoter, regulation expression. expression was predominantly nuclear, as determined by RNA nucleoplasmic separation and fluorescence situ hybridization. Knockdown nucleus, not cytoplasm, significantly decreased PRKAG2b PRKAG2d . Interestingly, found that its target genes, were reduced hearts...
Metazoan histone mRNAs are the only cellular eukaryotic that not polyadenylated, ending instead in a conserved stem–loop. SLBP is bound to 3′ end of and required for translation mRNA. The expression tightly cell-cycle regulated. A major regulatory step rapid degradation mRNA at S-phase or when DNA synthesis inhibited S-phase. 3′hExo, 5′ exonuclease, binds SLBP/SL complex trims 3 nt after Together with terminal uridyl transferase, 3′hExo maintains length during essential initiating on...
Purpose: To determine the effect of micro-ribonucleic acid-200c (miR-200c) on biological function nasopharyngeal carcinoma, and likely molecular regulatory mechanism involved.Methods: Thirty (30) carcinoma tissues para-cancerous normal were taken from patients undergoing surgery in Maternal Child Health Hospital Hubei Province, Wuhan September 2018 to January 2020. The expression levels miR-200c two types determined. Cells human cell line HNE1 cultured about 70 % growth prior transfection...
With the advent of new media era, all kinds platform software have updated rapidly. In addition, college students have, through network and mobile terminal, obtained ways obtaining information expressing themselves, this has resulted in communication becoming an important part their life. All events world rapidly attracted popular attention hot emerged. This article begins by assessing feasibility necessity integrating into professional course surgical nursing, as a way carrying out...
Through the investigation and interview of Nanta Street Health Service Center, telephone follow-up elderly patients with hypertension diabetes, to understand current situation chronic disease management explore community intervention strategy undergraduate nursing students. In October 2021, data 200 and/or diabetes mellitus were randomly exported from system center, staff center also examined interviewed. The whose telephonically followed up by cut-off date January 2022. According their...