A5100611748- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Retinal Imaging and Analysis
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- AI in cancer detection
- Retinal Diseases and Treatments
- Concrete and Cement Materials Research
- Lung Cancer Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Nuts composition and effects
- Glaucoma and retinal disorders
- Cancer, Lipids, and Metabolism
- Generative Adversarial Networks and Image Synthesis
- Innovative concrete reinforcement materials
- Piperaceae Chemical and Biological Studies
- Advanced Radiotherapy Techniques
- Geothermal Energy Systems and Applications
- Air Quality and Health Impacts
- Optical Coherence Tomography Applications
University of Iowa
2022-2025
Xiangnan University
2017-2024
Guangzhou Medical University
2013-2024
Macao Polytechnic University
2023-2024
Zhongnan Hospital of Wuhan University
2009-2024
Wuhan University
2009-2024
Nanjing Medical University
2024
Soochow University
2024
Sun Yat-sen University
2024
Nanchang Hangkong University
2024
Hepatocellular carcinoma (HCC) is a leading cause of cancer death in many Asian and African countries. Lack early diagnosis tools one the clinical obstacles for effective treatment HCC. Thus, enhanced understanding molecular changes associated with HCC urgently needed to develop novel strategies this dismal disease. While aberrant expression long noncoding RNAs (lncRNAs) has been functionally certain cancers, profiles biological relevance lncRNAs remain unclear. Highly upregulated liver...
Abstract Emerging evidence indicates that exosomes derived from gastric cancer cells enhance tumor migration and invasion through the modulation of microenvironment. However, it remains a major problem to detect cancer‐specific due technical biological challenges. Most methods reported could not achieve efficient detection tumor‐derived in background normal exosomes. Herein, label‐free electrochemical aptasensor is presented for specific This platform contains an anti‐CD63 antibody modified...
Abstract Vascularization is crucial for bone regeneration after the transplantation of tissue-engineered grafts in clinical setting. Growing evidence suggests that mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are potently pro-angiogenic both vitro and vivo . In current study, we fabricated a novel EV-functionalized scaffold with enhanced pro-bone activities by coating decalcified matrix (DBM) MSC-derived EVs. EVs were harvested from rat marrow-derived MSCs potential was...
Senescence in human mesenchymal stem cells (MSCs) not only contributes to organism aging and the development of a variety diseases but also severely impairs their therapeutic properties as promising cell therapy.Studies searching for efficient biomarkers that represent cellular senescence have attracted much attention; however, no single marker currently provides an accurate cell-free representation senescence.Here, we studied characteristics MSC-derived microvesicles (MSC-MVs) may reflect...
Cancer-associated fibroblasts (CAFs) promote cancer stem cell (CSC)-mediated chemoresistance and immunosuppressive tumor microenvironment. However, direct depletion of CAFs may increase invasiveness metastasis. As a generalized strategy against chemoresistant cancers, Gemini-like homotypic targeting nanoparticles (NPs) are designed for two-pronged CAF transformation elimination. The CAF-targeted NPs couple vitamin B3 metabolic reprogramming to epigenetic modulation secreted pro-stemness...
Intrathecal injection of 12 nmol dynorphin elicited marked analgesia as measured by tail flick latency, the effect being about 20 times more potent than with morphine. This analgesic could be reversed naloxone at a dose 1.5-fold higher that needed to reverse morphine analgesia. anti-dynorphin antibody blocked electroacupuncture (EA) 77%, lasting for least 4 h. In rabbits made tolerant EA long-term stimulation, intrathecal no longer exhibited an effect. No was noticed when (10 nmol) injected...
Background: As a hallmark driver of multiple myeloma (MM), MM bone disease (MBD) is unique in that it characterized by severely impaired osteoblast activity resulting from blocked osteogenesis marrow-derived mesenchymal stem cells (BM-MSCs).The mechanisms underlying this preferential blockade are incompletely understood.Methods: miRNA expression cell-derived extracellular vesicles (MM-EVs) was detected RNA sequencing.MM-EVs and exacerbated MBD were vitro vivo validated histochemical...
One of the major challenges bone tissue engineering applications is to construct a fully vascularized implant that can adapt hypoxic environments in vivo. The incorporation proangiogenic factors into scaffolds widely accepted method achieving this goal. Recently, potential mesenchymal stem cell-derived microvesicles (MSC-MVs) has been confirmed several studies. In present study, we incorporated MSC-MVs alginate-polycaprolactone (PCL) constructs had previously developed for applications, with...
Background/Aims: Hepatocellular carcinoma (HCC) has a high morbidity as well mortality and is believed to be one of the most prevalent cancers worldwide. The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) involved in numerous cancers, including HCC. This study aimed explore role MALAT1 HCC progression. Methods: expression levels Vimentin tissues relative pair-matched adjacent normal liver were analyzed by RT-PCR, immunohistochemistry. Using bioinformatics...
// Zhaoyu Liu 1, * , Lei Han 2, Yucui Dong Yanli Tan 3, Yongsheng Li 4 Manli Zhao 1 Hui Xie Huanyu Ju He Wang Yu Qifan Zheng Qixue 5 Jun Su 6 Chuan Fang 7 Songbin Fu 8 Tao Jiang 9 Jiaren 10 Xia Chunsheng Kang Huan Ren Department of Immunology, Harbin Medical University, 150081, China 2 Neurosurgery, Tianjin University General Hospital, 300052, 3 College Fundamental Medicine, Hebei Baoding 071000, Bioinformatics, Laboratory Neuro-Oncology, Neurological Institute, The Oncology Hospital...
The study aims to assess the thickness of retinal outer nuclear layer (ONL), ellipsoid zone (EZ) and photoreceptor segment (POS) band in various macular regions its associations with axial length other parameters. Participants Beijing Eye Study 2011 underwent a series examinations including spectral-domain optical coherence tomography macula. current included 2213 participants without or optic nerve diseases (age: 61.7 ± 8.4 years; range 50-93 years); length: 23.15 0.95 mm; 18.96-29.15 mm)....
Multiple-surface segmentation in optical coherence tomography (OCT) images is a challenging problem, further complicated by the frequent presence of weak image boundaries. Recently, many deep learning-based methods have been developed for this task and yield remarkable performance. Unfortunately, due to scarcity training data medical imaging, it learning networks learn global structure target surfaces, including surface smoothness. To bridge gap, study proposes seamlessly unify U-Net feature...
Abstract Although increasing long noncoding RNAs (lncRNAs) have been identified by high‐throughput sequencing, their functions in human cancer remain largely unknown. The function of lncRNA miR143HG has not explored before. In the present study, we found that expression was significantly downregulated bladder tissues (BCa) compared with normal tissues. We showed high associated a survival rate BCa patients. Gain‐of‐function assays demonstrated overexpression suppressed proliferation,...