A5100461491- Hydrogels: synthesis, properties, applications
- Lignin and Wood Chemistry
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Polysaccharides Composition and Applications
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Advanced Cellulose Research Studies
- Graphene and Nanomaterials Applications
- Advanced Polymer Synthesis and Characterization
- Polysaccharides and Plant Cell Walls
- Molecular Sensors and Ion Detection
- Organic Light-Emitting Diodes Research
- Enzyme-mediated dye degradation
- Analytical Chemistry and Sensors
- Nanocomposite Films for Food Packaging
- Biofuel production and bioconversion
- Dendrimers and Hyperbranched Polymers
- Electrochemical sensors and biosensors
- Photonic and Optical Devices
Chinese Academy of Sciences
2015-2025
Sun Yat-sen University
2016-2025
Dalian Institute of Chemical Physics
1997-2025
Beijing Chao-Yang Hospital
2008-2025
Capital Medical University
2008-2025
Guangdong Medical College
2025
Second Affiliated Hospital of Zhejiang University
2024-2025
Ningxia Medical University
2016-2025
Peking University People's Hospital
2018-2025
Peking University
2006-2025
Graphene exhibits unique 2-D structure and exceptional phyiscal chemical properties that lead to many potential applications.Among various applications, biomedical applications of graphene have attracted ever-increasing interests over the last three years.In this review, we present an overview current advances in biomedicine with focus on drug delivery, cancer therapy biological imaging, together a brief discussion challenges perspectives for future research field.
Mimicking proton conduction mechanism of Nafion to construct novel proton-conducting materials with low cost and high conductivity is wide interest. Herein, we have designed synthesized a cationic covalent organic framework thermal chemical stability by combining monomer, ethidium bromide (EB) (3,8-diamino-5-ethyl-6-phenylphenanthridinium bromide), 1,3,5-triformylphloroglucinol (TFP) in Schiff base reactions. This the first time that stable crystalline frameworks allowed for fabrication...
Loading and delivery of Bcl-2-targeted short interfering RNA (siRNA) anticancer drug doxorubicin (DOX) by polyethylenimine (PEI)-conjugated graphene oxide (PEI-GO) is studied. A higher knockdown efficiency siRNA delivered PEI-GO than PEI achieved. Sequential DOX the nanocarrier shows a synergistic effect, which leads to significantly improved chemotherapy efficacy. Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not...
Abstract Many tumor cells shed specialized membrane vesicles known as exosomes. In this study, we show that pretreatment of mice with exosomes produced by TS/A or 4T.1 murine mammary resulted in accelerated growth implanted both syngeneic BALB/c and nude mice. As grew more rapidly had been depleted NK cells, analyzed the effects tumor-derived on cells. The inhibit cell cytotoxic activity ex vivo vitro demonstrated chromium release assays. treatment also led to a reduction percentages...
In this paper, we describe the formation of Au nanoparticle-graphene oxide (Au-GO) and -reduced GO (Au-rGO) composites by noncovalent attachment nanoparticles premodified with 2-mercaptopyridine to rGO sheets, respectively, via π–π stacking other molecular interactions. Compared in situ reduction HAuCl4 on surface graphene sheets that are widely used prepare Au-GO composites, approach developed us offers well controlled size, size distribution, morphology metal metal-GO nanohybrids....
Background: To investigate deep vein thrombosis (DVT) in hospitalized patients with coronavirus disease 2019 (COVID-19), we performed a single institutional study to evaluate its prevalence, risk factors, prognosis, and potential thromboprophylaxis strategies large referral treatment center. Methods: We studied total of 143 COVID-19 from January 29, 2020 February 2020. Demographic clinical data, laboratory including ultrasound scans the lower extremities, outcome variables were obtained,...
Abstract The production of exosomes by tumor cells has been implicated in tumor-associated immune suppression. In this study, we show that, mice, produced TS/A murine mammary target CD11b+ myeloid precursors the bone marrow (BM) vivo, and that is associated with an accumulation spleen. Moreover, demonstrate block differentiation precursor into dendritic (DC) vitro. Addition at day 0 led to a significant DC, whereas addition later time points was less effective. Similarly, human breast...
A novel gene delivery system based on graphene oxide chemically-functionalized with branched polyethylenimine (PEI-GO) is reported. The PEI-GO conjugate was formed by the covalent linking of PEI and GO via an amide bond widely used EDC chemistry. Thus-prepared exhibits excellent ability to condense DNA at a low mass ratio positive potential 49 mV. WST assay reveals that significantly less cytotoxic than 25 kDa. Finally, transfection efficiency evaluated. It demonstrated luciferase expression...
Replacement of the central, para-substituted fluorophenyl ring in γ-secretase inhibitor 1 (BMS-708,163) withthe bicyclo[1.1.1]pentane motif led to discovery compound 3, an equipotent enzyme with significant improvements passive permeability and aqueous solubility. The modified biopharmaceutical properties 3 translated into excellent oral absorption characteristics (∼4-fold ↑ Cmax AUC values relative 1) a mouse model inhibition. In addition, SAR studies other replacements indicate intrinsic...
Formation of composites dextran-coated Fe(3)O(4) nanoparticles (NPs) and graphene oxide (Fe(3)O(4)-GO) their application as T(2)-weighted contrast agent for efficient cellular magnetic resonance imaging (MRI) are reported. Aminodextran (AMD) was first synthesized by coupling reaction carboxymethyldextran with butanediamine, which then chemically conjugated to meso-2,3-dimercaptosuccinnic acid-modified NPs. Next, the AMD-coated NPs were anchored onto GO sheets via formation amide bond in...
A two-dimensional cationic covalent organic framework membrane with extraordinary separation properties and high permeability.
We describe a facile approach to controllable assembly of monodisperse Fe3O4 nanoparticles (NPs) on chemically reduced graphene oxide (rGO). First, reduction and functionalization GO by polyetheylenimine (PEI) were achieved simultaneously simply heating the PEI mixture at 60 °C for 12 h. The process is environmentally friendly convenient compared with previously reported methods. Meso-2,3-dimercaptosuccinnic acid (DMSA)-modified NPs then conjugated moiety which located periphery sheets via...
The advent of bioethanol production has generated abundant lignin-derived byproducts which contain proteins and polysaccharides. These are inapplicable for direct material applications. In this study, were used the first time as carbon precursors to construct an interconnected hierarchical porous nitrogen-doped (HPNC) via hydrothermal treatment activation. obtained HPNC exhibited favorable features supercapacitor applications, such bowl-like pore structures, a large specific surface area...
ABSTRACT Recently, attempts have been made to apply graphene oxide (GO) in the field of biology and medicine, such as DNA sensing drug delivery with some necessary modifications. Therefore, toxicity GO must be evaluated before it is applied further biomedicine. In this paper, cytotoxicity genotoxicity human lung fibroblast (HLF) cells assessed methyl thiazolyl tetrazolium (MTT), sub‐G1 measurement comet assays, mechanism its has explored. Various modifications help us determine factors which...
Renewable graphene-like nitrogen-doped carbon nanosheets were constructed from layered shrimp shells with integrated high energy–power supercapacitive properties.
0D hybrid metal halides (0D HMHs) are considered to be promising luminescent emitters. HMHs commonly exhibit self-trapped exciton (STE) emissions originating from the inorganic halide anion units. Exploring and utilizing emission features of organic cation units in is highly desired enrich their optical properties as multifunctional materials. Here, tunable successfully achieved triphenylsulfonium (Ph3 S+ )-based HMHs. Notably, integrated afterglow STE with adjustable intensities obtained...