A5100358854- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Bioactive Compounds and Antitumor Agents
- Anesthesia and Neurotoxicity Research
- Inflammatory mediators and NSAID effects
- Fungal Biology and Applications
- Intensive Care Unit Cognitive Disorders
- RNA modifications and cancer
- Cholesterol and Lipid Metabolism
- Neuropeptides and Animal Physiology
- Microbial Natural Products and Biosynthesis
- Metal-Organic Frameworks: Synthesis and Applications
- Neuroscience and Neuropharmacology Research
- Synthesis of Organic Compounds
- Hydrogen's biological and therapeutic effects
- Carcinogens and Genotoxicity Assessment
- X-ray Diffraction in Crystallography
- Polyoxometalates: Synthesis and Applications
- Plant biochemistry and biosynthesis
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Crystallization and Solubility Studies
Harbin Medical University
2013-2025
Fourth Affiliated Hospital of Harbin Medical University
2008-2025
First Affiliated Hospital of Jinan University
2021-2025
China National Research Institute of Food and Fermentation
2025
Institute on Aging
2025
First People's Hospital of Yunnan Province
2025
Kunming University of Science and Technology
2023-2025
Jilin Academy of Agricultural Sciences
2025
Harvard University
2009-2024
Harbin Institute of Technology
2023-2024
The increasing incidence of hepatocellular carcinoma (HCC) is great concern not only in the United States but throughout world. Although sorafenib, a multikinase inhibitor with antiangiogenic and antiproliferative effects, currently sets new standard for advanced HCC, tumor response rates are usually quite low. An understanding underlying mechanisms sorafenib resistance critical if outcomes to be improved. In this study we tested hypothesis that hypoxia caused by effects sustained therapy...
The total phenolic content, flavonoid vitamin C and antioxidant activities of ethanol extracts from different kiwifruit varieties (Actinidia kolomikta, Actinidia arguta, chinensis) were determined in this study. Multiple scavenging activity assays including the hydroxyl radical, O2−·radical, DPPH, ABTS+ radical used to identify extracts. cell viability HepG2 HT-29 cells was also examined results demonstrated that kolomikta extract had a higher than other two There is positive correlation...
An efficient, cost-effective and environmentally friendly ultrasound-assisted hot water method for Imperata cylindrica polysaccharide (ICPs) extraction was developed. According to the response surface results, optimal ultrasonic time 85 min, power 192.75 W, temperature 90.74 °C, liquid–solid ratio 26.1, yield 28.50 %. The mainly consisted of arabinose (Ara), galactose (Gal), glucose (Glc), with a molecular weight 62.3 kDa. Ultrasound-assisted (UICP) exhibited stronger anti-oxidant activity...
Regular consumption of fruits and vegetables has been consistently shown to be associated with reduced risk developing chronic diseases such as cancer cardiovascular disease. Apples are commonly consumed the major contributors phytochemicals in human diets. It was previously reported that apple extracts exhibit strong antioxidant antiproliferative activities part total activity is from combination phytochemicals. Phytochemicals, including phenolics flavonoids, suggested bioactive compounds...
Background Prolonged exposure to ketamine results in accelerated neurodegeneration and neurocognitive deficits the neonatal rats. Experimental models of have implicated reentry postmitotic neurons into cell cycle, leading death. The authors hypothesize that ketamine-induced neuroapoptosis is partially due aberrant cycle reentry. To explore this hypothesis, characterized effect on signaling pathway developing rodent brain vivo vitro. Methods Postnatal day 7 rat pups primary were used for...
Although gankyrin is involved in the tumorigenicity and metastasis of some malignancies, role cholangiocarcinoma (CCA) unclear. In this study we investigated expression human CCA tissues cell lines. The effects on tumor growth were determined both vivo vitro . results showed that was overexpressed Gankyrin associated with histological differentiation, TNM stage, metastasis. multivariate Cox analysis revealed an independent prognostic indicator for overall survival. overexpression promoted...
Ketamine induces neuroapoptosis in neonatal rodents. However, these experimental paradigms were performed without concurrent noxious stimulation, a condition that does not reflect the interaction of anesthesia and surgical stimulation. Noxious stimulation with analgesic drugs has been shown to have divergent patterns neuronal activation cell death. We hypothesized would attenuate ketamine-induced caspase-3 activation.Postnatal day 7 Sprague-Dawley rat pups randomized 6-h exposure ketamine...
A new one-dimensional chain-like compound of tungstobismuthate, [(W(OH)2)2 (Mn(H2O)3)2(Na3(H2O)14)(BiW9O33)2](Himi)2·16H2O (1) (imi = iminazole), has been synthesized in aqueous solution. The structure 1 was identified by elemental analysis, IR, thermogravimetry (TG), X-ray photoelectron spectroscopy (XPS), 183W-NMR, and single crystal diffraction. To investigate the inhibitory effect on human gastric adenocarcinoma SGC-7901 cells, cell proliferation apoptosis initiation were examined MTT...
The effects of Tartary buckwheat bran extract (TBBE) on antioxidation status and lipid profile were determined in hyperlipemic rats. Seven-week-old male Wistar rats fed a high-fat diet to induce hyperlipemia with doses TBBE at 0.2 (low), 0.5 (medium), 1.0 (high) g/kg body weight. positive control group was the or supplemented Gynostemma pantaphyllum total glucoside tablet 0.032 negative basal diet. blood lipids, liver antioxidant-related parameters measured. indicated that could effectively...
beta-Ionone demonstrates potent anticancer activity both in vitro and vivo. We determined tumor incidence the number of rats bearing tumors as well cell proliferation apoptosis a rat mammary cancer model induced by 7, 12-dimethylbenz[a]anthracene (DMBA). Rats were fed an AIN-76A diet containing beta-ionone (0, 9, 18 or 36 mmol/kg), starting 2 weeks before DMBA administration continuing for 24 weeks. A dose-dependent inhibition carcinogenesis dietary was observed. Corresponding values 82.1,...
Tocotrienols have been shown to inhibit proliferation and induce apoptosis in cancer cells. However, the molecular mechanisms involved tocotrienol-induced are still unclear. In present study, gamma-tocotrienol induced human gastric adenocarcinoma SGC-7901 cell line through down regulation of extracellular signal-regulated kinase (ERK) signalling pathway. Furthermore, gamma-tocotrienol-induced was accompanied by Bcl-2, up Bax, activation caspase-3, subsequent poly (ADP-ribose) polymerase...
Whole apple extracts possess potent antioxidant activity and antiproliferative against cancer cells in vitro. The objectives of this study were to determine the anticancer a rat mammary model induced by 7,12-dimethylbenz(a)anthracene (DMBA) vivo if inhibited cell proliferation affected apoptosis tissues vivo. Rats given whole (0, 3.3, 10.0, or 20.0 g/kg body weight) gavage starting 2 weeks prior DMBA administration continuing for 24 weeks. treated with (positive control) developed tumors...
Gankyrin has shown to be overexpressed in human liver cancers and plays a complex role hepatocarcinogenesis. Panobinostat (LBH589), new hydroxamic acid-derived histone deacetylase inhibitor promising anticancer effects recently. Here, we investigated the potential of LBH589 as form treatment for hepatocellular carcinoma (HCC).Gankyrin plasmid was transfected into HCC cells, cells were selected more than 4 weeks by incubation with G418 overexpression clones. The therapeutic evaluated vitro...
A new cobalt-based polyoxometalate, (Himi)2[Bi(2)W2(0)O(66)(OH)(4)Co2(H2O)(6)Na(4) (H2O)14] · 17H2O (imi = iminazole) (BWCN) has been synthesized and structurally characterized. The inhibitory activities against selected human cancer lines were also determined in this study. cell viability chemoresistance of BWCN on colon carcinoma HT-29 cells assessed by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazoliumbromide), morphology changes, a comet assay western blot analysis. typical...