A5023804734- Hydrogen's biological and therapeutic effects
- Anesthesia and Neurotoxicity Research
- Biochemical effects in animals
- Electron Spin Resonance Studies
- Cardiac Ischemia and Reperfusion
- Advanced battery technologies research
- Hydrogen Storage and Materials
- Magnetism in coordination complexes
- Lanthanide and Transition Metal Complexes
- Nanoplatforms for cancer theranostics
- Inhalation and Respiratory Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Cardiovascular Function and Risk Factors
Harbin Medical University
2021-2025
Fourth Affiliated Hospital of Harbin Medical University
2021-2025
Abstract It is noteworthy that prolonged cardiac structural changes and excessive fibrosis caused by myocardial infarction (MI) seriously interfere with the treatment of heart failure in clinical practice. Currently, there are no effective practical means either prevention or treatment. Thus, novel therapeutic approaches critical for long‐term quality life individuals ischaemia. Herein, we aimed to explore protective effect H 2 , a gas signal molecule anti‐oxidative stress anti‐inflammatory...
Acute myocardial infarction (AMI) is a deadly cardiovascular disease with no effective solution except for percutaneous coronary intervention and artery bypass grafting. Inflammation apoptosis of the injured myocardium after revascularization seriously affect prognosis. Hydrogen possesses anti-inflammatory, anti-oxidative, anti-apoptotic effects may become new treatment AMI. This study explored specific mechanism by which hydrogen operates during AMI treatment. Thirty Sprague-Dawley rats...
Abstract Molecular hydrogen is an emerging broad-spectrum antioxidant molecule that can be used to treat myocardial infarction (MI). However, with inhalation, the concentration reached within target organs low and duration of action short, which makes it difficult achieve high dose targeted delivery heart, seriously limiting therapeutic potential for MI. As a result reactions internal environment body, subcutaneous implantation magnesium slices leads continuous endogenous production, leading...
Abstract Hydrogen gas is recently proven to have anti‐oxidative and anti‐inflammation effects on ischemia‐reperfusion injury. However, the efficacy of hydrogen therapy limited by efficiency storage, targeted delivery, controlled release. In this study, H 2 ‐PFOB nanoemulsions (NEs) developed with high loading capacity for ischemic myocardium precision therapy. The hydrogen‐carrying NEs determined chromatography microelectrode methods. Positive uptake in influence 19 F‐MR signal are...
Recently, radiotherapy (RT) has entered a new realm of precision cancer therapy with the introduction magnetic resonance (MR) imaging guided systems into clinic. Nonetheless, identifying an optimized time window (ORTW) is still critical for best therapeutic efficacy RT. Here we describe pH and O2 dual-sensitive, perfluorooctylbromide (PFOB)-based glycerol-weighted chemical exchange saturation transfer (CEST) nano-molecular probes (Gly-PFOBs) dual fluorine hydrogen proton based CEST MR...
Purpose: Hydrogen (H2) is an antioxidant with anti-inflammatory and apoptosis functions.This study aimed to estimate the effects of H2 on acute myocardial infarction (AMI) in rats its association inhibition oxidative stress cardiomyocyte pyroptosis.Methods: Sixty-four were randomly divided into three groups (Sham, AMI, H2).The left anterior descending coronary artery (LAD) AMI was ligated, while Sham group threaded without ligation.In addition, 2% administered by inhalation for 24 h after...
The currently available immune checkpoint inhibitors (ICIs) often fail to achieve the desired clinical outcomes due inadequate activation, particularly in patients with lung cancer. To reverse this situation, we synthesized inhalable PFCE-C25 nanoemulsions (NEs), which target lymphocyte activation genes (LAG-3) on cells within tumor microenvironment and tumor-draining lymph nodes (TDLNs). By combining vivo 19 F-MR molecular imaging, investigate immunological effects of a single low-dose NEs...
Abstract: The energy used by the heart is generated mainly metabolism of fatty acids and glucose. Trimetazidine (TMZ) inhibits acid for treatment diseases such as failure. 3-Bromopyruvate (3-BrPA) can suppress glucose metabolism, it considered a promising candidate agent tumor therapy. Because TMZ 3-BrPA separately inhibit 2 main cardiac sources, necessary to investigate effects combined with on heart. Forty male Wistar rats were randomly divided into 4 groups: control group, + group. Weight...