A5100372334- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Congenital Anomalies and Fetal Surgery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Intestinal Malrotation and Obstruction Disorders
- Circular RNAs in diseases
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Infant Nutrition and Health
- Cancer-related molecular mechanisms research
- Neuroblastoma Research and Treatments
- Blood disorders and treatments
- Chronic Myeloid Leukemia Treatments
- Pancreatic function and diabetes
- Polyomavirus and related diseases
- Neonatal Respiratory Health Research
- Abdominal Trauma and Injuries
- RNA modifications and cancer
- Cytomegalovirus and herpesvirus research
- Urinary and Genital Oncology Studies
Shenzhen Children's Hospital
2014-2025
China Medical University
2024
Capital Medical University
2013-2024
Beijing Children’s Hospital
2013-2024
National Center for Women and Children’s Health, China CDC
2024
Harbin Medical University
2022
Fourth Affiliated Hospital of Harbin Medical University
2022
Wuhan Children's Hospital
2022
Huazhong University of Science and Technology
2022
Chinese University of Hong Kong
2015
Highly conductive and biocompatible PEDOT:PSS hydrogels, prepared by using polymers as cross-linkers, can serve both an electrochemical sensor a 3D hydrogel scaffold to realize in situ sensing of DA secreted PC12 cells.
Maternal seeding of the microbiome in neonates promotes a long-lasting biological footprint, but how it impacts disease susceptibility early life remains unknown. We hypothesized that feeding butyrate to pregnant mice influences newborn's biliary atresia, severe cholangiopathy neonates. Here, we show administration mothers renders newborn resistant inflammation and injury bile ducts improves survival. The prevention hepatic immune cell activation survival trait is linked fecal signatures...
Introduction Finding non-invasive methods to predict the degree of liver fibrosis is very important in managing children with biliary atresia. Therefore, we explored predictive value APRI, FIB-4, and serological markers for Methods This study retrospectively reviewed data from diagnosed BA between March December 2022. Liver tissue pathology specimens were obtained during surgery. The serum measured within 2 days before Kasai procedure or transplantation. aspartate...
Biliary atresia (BA) is a pediatric liver disease characterized by fibro-obliteration and obstruction of the extrahepatic biliary system, that invariably leads to cirrhosis even death, if left untreated for extended time. However, its pathology etiology still remained unknown. In this study, we tested expression adducin 3 (ADD3), gene identified as susceptibility in BA GWAS, uncovered upstream regulatory microRNA pathogenesis BA.In 14 infants with choledochal cyst (CC) were enrolled...
Background and Objective: Intravenous contrast-enhanced ultrasound (CEUS), using the second-generation contrast agent SonoVue®, has been widely used in adults. In 2016, it was approved for pediatric applications by American Food Drug Administration (FDA). However, not Chinese (CFDA). The objective of study to evaluate safety effectiveness CEUS children prospectively at a single center China. Method: A total 312 cases were enrolled clinical trials. Contrast given intravenously with two...
Objective This study aims to analyze and summarize the clinical characteristics of small intestinal adenomyosis. Methods A retrospective was conducted on children with adenomyosis at our center from 2014 2024. The age onset, gender, symptoms, auxiliary examination results, treatment plans, pathological tumors were recorded analyzed. Results Six cases male-to-female ratio 5:1. median 19 months, two-thirds affected being under 2 years old. Two identified in newborns during malrotation....
The delay in platelet recovery after hematopoietic stem cell transplantation (HSCT) is closely related to the overall survival rate of transplanted children. use platelet-producing agents such as eltrombopag and romiplostim has made great progress treating diseases immune thrombocytopenia aplastic anemia. However, drugs patients with transplantation, especially children, rare. This study aimed report treatment for 3 children primary engraftment failure secondary allogeneic HSCT. Of these...
Biliary atresia (BA) is an infantile fibro-obstructive cholestatic disease with poor prognosis. An early diagnosis and timely Kasai portoenterostomy (KPE) improve clinical outcomes. Aggregation of amyloid-beta (Aβ) around hepatic bile ducts has been discovered as a factor for BA pathogenesis, yet whether plasma Aβ levels correlate dysfunctions could be biomarker remains unknown. Plasma samples 11 24 controls were collected liver function test, Aβ40 Aβ42 measurement by enzyme-linked...
Background Hepatic stellate cell (HSC) activation and hepatic fibrosis mediated biliary atresia (BA) development, but the underlying molecular mechanisms are poorly understood. This study aimed to investigate roles of circRNA hsa_circ_0009096 in regulation HSC proliferation fibrosis. Methods A cellular model was established by treating LX-2 cells with transforming growth factor β (TGF-β1). RNaseR actinomycin D assays were performed detect stability. Expression hsa_circ_0009096, miR-370-3p,...
Background: BK virus (BKV) is one of the most common causes hemorrhagic cystitis (HC) in children undergoing hematopoietic stem cell transplantation (HSCT). Viruses can be found urine and serum immunocompromised patients. Objective: This study aimed to evaluate incidence, clinical course, risk factors for BKV infection HSCT. Methods: Retrospectively analyzed who underwent HSCT at Beijing Children’s Hospital, Capital Medical University from June 2020 2022. Data related manifestations,...
To compare the surgical outcomes of Kasai Portoenterostomy (PE) and investigate learning curve laparoscopic (Lap-PE).Retrospective chart review 80 cases biliary atresia (type III) undergoing Lap-PE at Shenzhen Children's Hospital from January 2011 to June 2015, all which were performed by same team. According operative sequences, equally divided into four phases (Phase I, II, III, IV), contain 20 in each. The age, weight, gender, volume intraoperative blood loss, postoperative clearance rate...
Objective To elaborate on the implementation and achievements of a biliary atresia (BA) screening programme in Shenzhen. Methods In 2015, we partnered with government Shenzhen attached stool colour card (SCC) to health handbook for mothers children. These handbooks have been distributed through official channels every pregnant woman since 1 January 2015. A total 118 patients diagnosed BA at Children’s Hospital were enrolled divided into two cohorts based their date diagnosis: cohort before B...
Biliary atresia (BA) is a devastating liver disease in neonates. Liver fibrosis regarded as universal and prominent feature of BA. Studies have revealed that long non-coding RNAs (lncRNAs) regulate cellular processes during the development Long RNA-adducin 3 antisense RNA1 (lnc-ADD3-AS1) has been shown to increase susceptibility However, role lnc-ADD3-AS1 BA remains unclear. Here, we investigated proliferation, migration, apoptosis immortalized human hepatic stellate cell (HSC) line, LX-2....
This study was designed to investigate the potential role of microRNA-29c (miR-29c) in biliary atresia-related fibrosis. The expression miR-29c determined 15 pairs peripheral blood samples from infants with atresia (BA) and non-BA neonatal cholestasis using quantitative real-time PCR. EMT established by induction TGF-β1 HIBEpiC cells. MiR-29c inhibited lipofectamine transfection. expressions proteins related epithelial–mesenchymal transition (EMT), i.e., E-cadherin, N-cadherin vimentin, were...
Choledochal cysts (CC) are congenital bile duct anomalies with 6-30% risk for developing cancer. However, the molecular mechanisms underlying cancer of CC unknown. We sought to identify gene expression changes patients.Liver organoids (n = 51) were generated from liver/bile biopsies 7; type I) and hepatoblastoma 5; HB: non-tumor & tumor) RNA sequencing. Bioinformatics analysis was conducted differentially expressed cancer-related genes in controls. compared non-cancerous cancerous controls,...