A5062390708- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Transplantation: Methods and Outcomes
- Congenital Anomalies and Fetal Surgery
- Renal Transplantation Outcomes and Treatments
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Organ Donation and Transplantation
- Gallbladder and Bile Duct Disorders
- Hepatitis C virus research
- Neonatal Health and Biochemistry
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolism and Genetic Disorders
- Hepatitis Viruses Studies and Epidemiology
- Antibiotic Resistance in Bacteria
- Renal and Vascular Pathologies
- Global Maternal and Child Health
- Liver physiology and pathology
- Platelet Disorders and Treatments
- Immune cells in cancer
- T-cell and B-cell Immunology
- Acute Kidney Injury Research
Tianjin First Center Hospital
2016-2025
Tianjin Medical University
2016-2025
Tianjin University
2019-2024
Sichuan University
2024
Nanjing Medical University
2023
Tianjin People's Hospital
2019-2021
Heilongjiang Provincial Hospital
2018-2020
Shanghai Clinical Research Center
2019
Committee on Publication Ethics
2018
Dalian Medical University
2017
Biliary atresia (BA) is a pediatric liver disease characterized by fibro-obliteration and obstruction of the extrahepatic biliary system, that invariably leads to cirrhosis even death, if left untreated for extended time. However, its pathology etiology still remained unknown. In this study, we tested expression adducin 3 (ADD3), gene identified as susceptibility in BA GWAS, uncovered upstream regulatory microRNA pathogenesis BA.In 14 infants with choledochal cyst (CC) were enrolled...
Background. Optimizing the immunosuppressive regimen is essential to improve long-term outcomes of pediatric liver transplant recipients. Methods. We conducted a prospective, randomized, open-label study compare safety and efficacy 2 treatment approaches during transplantation: tacrolimus monotherapy following basiliximab induction (the group) dual plus steroids control group). A total 150 patients were enrolled, with 75 allocated each group. Results. In both groups, recipients achieved...
The effectiveness of bone marrow mesenchymal stem cells (BMSCs) in post-transplantation liver fibrosis has not been studied. aim this study was to investigate the effect BMSCs on and their role Janus-activated kinase (JAK) 1/ signal transducer activator transcription (STAT) 5 pathway after transplantation (LT). A rat model post-LT induced by cold ischemia injury successfully established. were injected into rats through portal vein. Hepatic stellate cell (HSC)-T6 co-cultured with vitro...
Little is known about the magnitude of catastrophic health expenditure (CHE) attributable to critical disease, especially in middle-aged and elderly population. This research aimed exploring key aspects how insurance fails protect against CHE past five years. And propose corresponding measures improve. Data were obtained from 2011 2015 China Health Retirement Longitudinal Study. The method was adapted WHO calculate impoverishment by medical expense (IME), use Generalized Linear Mixed Models...
Abstract Background To explore the relevant factors for early liver transplantation (LT) after Kasai portoenterostomy (KP). Methods Retrospective analysis was performed 200 children with biliary atresia, who underwent LT hepatic failure KP. According to interval between KP and LT, they were divided into three groups: G1 (≤6-month), G2 (6-month~ 2-year) G3 (> 2-year). Gender, age of portoenterostomy, jaundice-clearance, cholangitis function indexes before compared among groups. Results The...
The lack of age- and size-matched organs result in higher waiting list mortality pediatric recipients than adults. Organs from deceased newborns infants are a valuable source to increase donor pool liver transplantation. However, the feasibility safety using neonatal donors have not been well evaluated.From 2014 2016, 48 transplantations with age younger 1 year old our center were enrolled this study. divided into three groups based on (<1 month, month ≤ <3 months, 3 months <1 year)....
The experience of using pediatric donors in split liver transplant is exceedingly rare. We aim to investigate the outcomes recipients receiving grafts. Sixteen grafts from 8 < 7 years were enrolled. donor and recipient characteristics, perioperative course, postoperative complications, graft survival rates evaluated. mean follow-up time was 8.0 ± 2.3 months. 100%. function remained normal range at end all recipients. No life-threatening complications seen these recipients, only...
BACKGROUND:Pediatric liver transplantation is used to treat children with end-stage disease. This study explored the research hotspots and bibliometric characteristics of pediatric through a variety analysis software. We conducted hotspot help determine important directions for future scientific research. MATERIAL AND METHODS:The samples were articles related published in PubMed past 5 years. The high-frequency keywords are extracted by BICOMB software, then binary matrix common word...
The aim of this study was to analyze the incidence and risk factors de novo HBV infection in pediatric patients receiving living donor liver transplants (LDLT) from HBcAb-positive donors, explore its treatment strategies. data 101 recipients LDLT Tianjin First Central Hospital between September 2006 December 2012 were retrospectively analyzed. markers regularly tested before after surgery, including HBsAb, HBsAg, HBeAg, HBeAb, HBcAb. median follow-up period 25.6 months, during which eight...
Donor shortage is an important limitation of liver transplantation (LT). Split (SLT) may increase the sources donors and reduce problem organ shortage. However, there are no standard criteria selection SLT donor, especially regarding donor age. We retrospectively analyzed clinical data children who received initial between January 2015 December 2021. Based on age donors, patients were divided into groups A (1-10 years old; n = 26), B (10-45 87), C (45-55 27). The short-term (<1 year after...
The goal of this study was to evaluate the efficacy a perioperative prophylactic strategy against de novo hepatitis B virus (HBV) infection in pediatric liver transplantation (LT) recipients with core antibody (HBcAb)–positive grafts. A total 482 transplanted between 2013 and 2017 were enrolled, 170 received HBcAb‐positive overall graft recipient survival rates HBcAb‐negative 91.8% versus 91.3% 95.3% 94.2% at end follow‐up. Preoperative surface (HBsAb) titer ≥ 1000 IU/L postoperative HBsAb...