A5018214046- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Renal Transplantation Outcomes and Treatments
- Liver physiology and pathology
- Diabetes Treatment and Management
- Biomedical Ethics and Regulation
- Single-cell and spatial transcriptomics
- Sarcoma Diagnosis and Treatment
- Cancer Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Organ and Tissue Transplantation Research
- Vascular Tumors and Angiosarcomas
- Bone and Joint Diseases
- Immunodeficiency and Autoimmune Disorders
- Transplantation: Methods and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Blood disorders and treatments
- Ginseng Biological Effects and Applications
- MRI in cancer diagnosis
- Diabetes Management and Research
- Blood groups and transfusion
- Cancer, Hypoxia, and Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
Tianjin First Center Hospital
2017-2025
Tianjin Medical University
2017-2025
Nankai University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
The effectiveness of bone marrow mesenchymal stem cells (BMSCs) in post-transplantation liver fibrosis has not been studied. aim this study was to investigate the effect BMSCs on and their role Janus-activated kinase (JAK) 1/ signal transducer activator transcription (STAT) 5 pathway after transplantation (LT). A rat model post-LT induced by cold ischemia injury successfully established. were injected into rats through portal vein. Hepatic stellate cell (HSC)-T6 co-cultured with vitro...
Abstract Recent emergence of SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.2.13, BA.4 and BA.5 all contain L452 mutations show potential higher transmissibility over BA.2. The new variants’ receptor binding immune evasion capability require immediate investigation, especially on the role substitutions. Herein, coupled with structural comparisons, we showed that BA.2 sublineages, including BA.2.12.1 exhibit increased ACE2-binding affinities compared to BA.1; while BA.4/BA.5 shows weakest...
This study aimed to explore whether serum CXCL8 concentration can be used as a noninvasive marker of subclinical rejection (SCR) after pediatric liver transplantation (pLT).Firstly, RNA sequencing (RNA-seq) was performed on 22 protocol biopsy samples. Secondly, several experimental methods were verify the RNA-seq results. Finally, clinical data and samples 520 LT patients in Department Pediatric Transplantation Tianjin First Central Hospital from January 2018 December 2019 collected.RNA-seq...
SARS-CoV-2 ancestral strain-induced immune imprinting poses great challenges to updating vaccines for new variants. Studies showed that repeated Omicron exposures could override induced by inactivated but not mRNA vaccines, a disparity yet be understood. Here, we analyzed the alleviation in vaccine (CoronaVac) cohorts after long-term period following breakthrough infections (BTI). We observed CoronaVac-vaccinated individuals who experienced BA.5/BF.7 BTI, proportion of Omicron-specific...
Rationale: Postliver transplant periampullary carcinoma is an extremely uncommon disease. Patient concerns: Cutaneous jaundice in a patient who had received liver 4 years earlier. Diagnosis: Periampullary carcinoma. Interventions: Radiofrequency ablation plus fully covered self-expanding metal stents (FCSEMS). Outcomes: The treatment of malignant neoplasm the ampulla Vater by radiofrequency FCSEMS placement was successful. No complications occurred. Lessons: This first reported case with...
Biliary atresia (BA) is the most common indication for pediatric liver transplantation, and biliary stricture (BS) remains an Achilles’ heel living donor transplantation (LDLT). We investigated impact of different ischemia times on BS after LDLT in patients with BA. retrospectively analyzed (<18 y) BA who underwent between January 2016 December 2020. Cases hepatic artery thrombosis, bile leakage, early (<2 wk), death (<3 mo) were excluded. In all, 572 cases included. A total 26...
Subclinical rejection (SCR) is a common injury in protocol biopsy after pediatric liver transplantation (pLT), but its effect on the recipient not clearly understood. We herein investigated incidence and risk factors involved SCR analyzed relationship between allograft fibrosis (AF).We retrospectively reviewed results from 507 children May 2013 2019, 352 patients underwent 2 years pLT, 203 5 48 both pLT.The of 5-year group was higher than that 2-year (20.2% vs.13.4%, respectively, p = .033)....
Abstract Background Leiomyosarcoma (LMS) is an uncommon mesenchymal neoplasm, which infrequently metastasizes to pancreas and thigh. Clinical presentation imaging findings of metastatic broad ligament LMS are often nonspecific. Complete excision plays important role in treatment patients with localized LMS. Case Here, we report a case 33-year-old woman recurrent metastasizing Previously, she was diagnosed underwent hysterectomy, bilateral salpingo-oophorectomy. The disease-free interval 2.5...
Abstract Background: NKX6.1 is a transcription factor for insulin, as well marker β cell maturity. Abnormal expression in cells, such translocation from the nucleus to cytoplasm or lost expression, has been shown dedifferentiation. Methods: Here, we obtained pancreata sections organ donors, and aim characterize subjects with without type 2 diabetes mellitus (T2DM), insulin immunofluorescence staining was performed. Results: Our results showed that cells but no nucleic (NKX6.1 Nuc- Ins + ),...
Abstract Background: NKX6.1 is a transcription factor for insulin, as well marker β cell maturity. Abnormal expression in cells, such translocation from the nucleus to cytoplasm or lost expression, has been shown dedifferentiation.Methods: Here, we obtained pancreata sections organ donors, and aim characterize subjects with without type 2 diabetes mellitus (T2DM), insulin immunofluorescence staining was performed.Results: Our results showed that cells but no nucleic (NKX6.1 Nuc- Ins + ),...
Rationale: Post-transplant lymphoproliferative disease (PTLD) is a serious complication after pediatric liver transplantation (pLT), which may lead to death. F-FDG PET/CT rarely considered in PTLD pLT and lacks clear diagnostic guidelines, especially the differential diagnosis of non-destructive PTLD. The aim this study was find quantifiable index identify pLT. Materials Methods: This retrospective collected data patients who underwent pLT, postoperative lymph node biopsy, at Tianjin First...