A5089018762- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Dye analysis and toxicity
- Neonatal and Maternal Infections
- Viral-associated cancers and disorders
- Bone and Joint Diseases
- CNS Lymphoma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Dyeing and Modifying Textile Fibers
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Clinical Nutrition and Gastroenterology
Tianjin First Center Hospital
2022-2025
Tianjin Medical University
2020-2025
Tianjin Children's Hospital
2021
China National Institute of Standardization
2017
The incidence of graft fibrosis is elevated following pediatric liver transplantation (pLT) and influenced by cold ischemic time (CIT). Myosin light chain 9 (MYL9), a member the myosin family, could act on hepatic stellate cells (HSCs) induce transition to active phase. We hypothesized that injury stimulate MYL9 expression lead fibrosis. tested hypothesis analyzing multi-omics data from human protocol biopsy samples 2 years after transplant, performing rat LT with different CIT conducting in...
The effectiveness of bone marrow mesenchymal stem cells (BMSCs) in post-transplantation liver fibrosis has not been studied. aim this study was to investigate the effect BMSCs on and their role Janus-activated kinase (JAK) 1/ signal transducer activator transcription (STAT) 5 pathway after transplantation (LT). A rat model post-LT induced by cold ischemia injury successfully established. were injected into rats through portal vein. Hepatic stellate cell (HSC)-T6 co-cultured with vitro...
Abstract Background To explore the relevant factors for early liver transplantation (LT) after Kasai portoenterostomy (KP). Methods Retrospective analysis was performed 200 children with biliary atresia, who underwent LT hepatic failure KP. According to interval between KP and LT, they were divided into three groups: G1 (≤6-month), G2 (6-month~ 2-year) G3 (> 2-year). Gender, age of portoenterostomy, jaundice-clearance, cholangitis function indexes before compared among groups. Results The...
This study aimed to explore whether serum CXCL8 concentration can be used as a noninvasive marker of subclinical rejection (SCR) after pediatric liver transplantation (pLT).Firstly, RNA sequencing (RNA-seq) was performed on 22 protocol biopsy samples. Secondly, several experimental methods were verify the RNA-seq results. Finally, clinical data and samples 520 LT patients in Department Pediatric Transplantation Tianjin First Central Hospital from January 2018 December 2019 collected.RNA-seq...
Biliary atresia (BA) is the most common indication for pediatric liver transplantation, and biliary stricture (BS) remains an Achilles’ heel living donor transplantation (LDLT). We investigated impact of different ischemia times on BS after LDLT in patients with BA. retrospectively analyzed (<18 y) BA who underwent between January 2016 December 2020. Cases hepatic artery thrombosis, bile leakage, early (<2 wk), death (<3 mo) were excluded. In all, 572 cases included. A total 26...
Abstract Background Posttransplant lymphoproliferative disease (PTLD) is a serious complication after pediatric liver transplantation (pLT), which may lead to death. 18 F‐FDG PET/CT rarely considered in PTLD pLT and lacks clear diagnostic guidelines, especially the differential diagnosis of nondestructive PTLD. The aim this study was find quantifiable index identify pLT. Methods This retrospective collected data patients who underwent pLT, postoperative lymph node biopsy, at Tianjin First...
Subclinical rejection (SCR) is a common injury in protocol biopsy after pediatric liver transplantation (pLT), but its effect on the recipient not clearly understood. We herein investigated incidence and risk factors involved SCR analyzed relationship between allograft fibrosis (AF).We retrospectively reviewed results from 507 children May 2013 2019, 352 patients underwent 2 years pLT, 203 5 48 both pLT.The of 5-year group was higher than that 2-year (20.2% vs.13.4%, respectively, p = .033)....
To the Editor: Biliary atresia (BA) is a biliary obstruction disease that affects lives of infants and young children. Kasai procedure (KP) improves outcomes BA, but it has not successfully solved various problems BA with postoperative inflammation bile duct liver fibrosis, intrahepatic cystic expansion (intrahepatic cysts, IBC), portal hypertension, function failure, etc. As result, most children still need transplantation (LT).[1] In recent years, dilatation duct, which may be an important...
Abstract Background To explore the relevant factors for early liver transplantation (LT) after Kasai portoenterostomy (KP). Methods Retrospective analysis was performed 200 children with biliary atresia, who underwent LT hepatic failure KP. According to interval between KP and LT, they were divided into three groups: G1 (≤6-month), G2 (6-month ~ 2-year) G3 (> 2-year). Gender, age of portoenterostomy, jaundice-clearance, cholangitis function indexes before compared among groups. Results...
Abstract Background： To explore the relevant factors for early liver transplantation (LT) after Kasai portoenterostomy (KP). Methods： Retrospective analysis was performed 200 children with biliary atresia, who underwent LT hepatic failure KP. According to interval between KP and LT, they were divided into three groups: G1 (≤6-month), G2 (6-month~2-year) G3 (>2-year). Gender, age of portoenterostomy, jaundice-clearance, cholangitis function indexes before compared among groups. Results：...
Rationale: Post-transplant lymphoproliferative disease (PTLD) is a serious complication after pediatric liver transplantation (pLT), which may lead to death. F-FDG PET/CT rarely considered in PTLD pLT and lacks clear diagnostic guidelines, especially the differential diagnosis of non-destructive PTLD. The aim this study was find quantifiable index identify pLT. Materials Methods: This retrospective collected data patients who underwent pLT, postoperative lymph node biopsy, at Tianjin First...
Although complete resolution and recovery occurs in most children with an initial attack of acute pancreatitis (AP), a subset may progress to recurrent AP (RAP). RAP has serious effects the individual socioeconomic burden. The aim this project was identify independent risk factors for pediatric so as provide evidence its prevention, early diagnosis treatment.A retrospective cohort study discharged from Tianjin Children's Hospital June 2017 January 2020 performed. Demographic clinical...